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Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA(2)LEN study

(2009) ALLERGY. 64(4). p.520-533
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Abstract
Chronic rhinosinusitis is one of the most common health care challenges, with significant direct medical costs and severe impact on lower airway disease and general health outcomes. The diagnosis of chronic rhinosinusitis (CRS) currently is based on clinical signs, nasal endoscopy and CT scanning, and therapeutic recommendations are focussing on 2 classes of drugs, corticosteroids and antibiotics. A better understanding of the pathogenesis and the factors amplifying mucosal inflammation therefore seems to be crucial for the development of new diagnostic and therapeutic tools. In an effort to extend knowledge in this area, the WP 2.7.2 of the GA(2)LEN network of excellence currently collects data and samples of 1000 CRS patients and 250 control subjects. The main objective of this project is to characterize patients with upper airway disease on the basis of clinical parameters, infectious agents, inflammatory mechanisms and remodeling processes. This collaborative research will result in better knowledge on patient phenotypes, pathomechanisms, and subtypes in chronic rhinosinusitis. This review summarizes the state of the art on chronic rhinosinusitis and nasal polyposis in different aspects of the disease. It defines potential gaps in the current research, and points to future research perspectives and targets.

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Chicago
Bachert, Claus, NICHOLAS VAN BRUAENE, E Toskala, Nan Zhang, H Olze, G Scadding, CM Van Drunen, et al. 2009. “Important Research Questions in Allergy and Related Diseases: 3-chronic Rhinosinusitis and Nasal Polyposis - a GA(2)LEN Study.” Allergy 64 (4): 520–533.
APA
Bachert, C., VAN BRUAENE, N., Toskala, E., Zhang, N., Olze, H., Scadding, G., Van Drunen, C., et al. (2009). Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA(2)LEN study. ALLERGY, 64(4), 520–533.
Vancouver
1.
Bachert C, VAN BRUAENE N, Toskala E, Zhang N, Olze H, Scadding G, et al. Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA(2)LEN study. ALLERGY. 2009;64(4):520–33.
MLA
Bachert, Claus, NICHOLAS VAN BRUAENE, E Toskala, et al. “Important Research Questions in Allergy and Related Diseases: 3-chronic Rhinosinusitis and Nasal Polyposis - a GA(2)LEN Study.” ALLERGY 64.4 (2009): 520–533. Print.
@article{803327,
  abstract     = {Chronic rhinosinusitis is one of the most common health care challenges, with significant direct medical costs and severe impact on lower airway disease and general health outcomes. The diagnosis of chronic rhinosinusitis (CRS) currently is based on clinical signs, nasal endoscopy and CT scanning, and therapeutic recommendations are focussing on 2 classes of drugs, corticosteroids and antibiotics. A better understanding of the pathogenesis and the factors amplifying mucosal inflammation therefore seems to be crucial for the development of new diagnostic and therapeutic tools. In an effort to extend knowledge in this area, the WP 2.7.2 of the GA(2)LEN network of excellence currently collects data and samples of 1000 CRS patients and 250 control subjects. The main objective of this project is to characterize patients with upper airway disease on the basis of clinical parameters, infectious agents, inflammatory mechanisms and remodeling processes. This collaborative research will result in better knowledge on patient phenotypes, pathomechanisms, and subtypes in chronic rhinosinusitis. This review summarizes the state of the art on chronic rhinosinusitis and nasal polyposis in different aspects of the disease. It defines potential gaps in the current research, and points to future research perspectives and targets.},
  author       = {Bachert, Claus and VAN BRUAENE, NICHOLAS and Toskala, E and Zhang, Nan and Olze, H and Scadding, G and Van Drunen, CM and Mullol, J and Cardell, L and Gevaert, Philippe and Van Zele, Thibaut and Claeys, Sofie and Hallden, C and Kostamo, K and Foerster, U and Kowalski, M and Bieniek, K and Olszewska-Ziaber, A and Nizankowska-Mogilnicka, E and Szczeklik, A and Swierczynska, M and Arcimowicz, M and Lund, V and Fokkens, W and Zuberbier, T and Akdis, C and Canonica, G and Van Cauwenberge, Paul and Burney, P and Bousquet, J},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  language     = {eng},
  number       = {4},
  pages        = {520--533},
  title        = {Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA(2)LEN study},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2009.01964.x},
  volume       = {64},
  year         = {2009},
}

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