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Genetic adaptation of influenza A viruses in domestic animals and their potential role in interspecies transmission : a literature review

(2016) ECOHEALTH. 13(1). p.171-198
Author
Organization
Project
FLURISK
Abstract
In December 2011, the European Food Safety Authority awarded a Grant for the implementation of the FLURISK project. The main objective of FLURISK was the development of an epidemiological and virological evidence-based influenza risk assessment framework (IRAF) to assess influenza A virus strains circulating in the animal population according to their potential to cross the species barrier and cause infections in humans. With the purpose of gathering virological data to include in the IRAF, a literature review was conducted and key findings are presented here. Several adaptive traits have been identified in influenza viruses infecting domestic animals and a significance of these adaptations for the emergence of zoonotic influenza, such as shift in receptor preference and mutations in the replication proteins, has been hypothesized. Nonetheless, and despite several decades of research, a comprehensive understanding of the conditions that facilitate interspecies transmission is still lacking. This has been hampered by the intrinsic difficulties of the subject and the complexity of correlating environmental, viral and host factors. Finding the most suitable and feasible way of investigating these factors in laboratory settings represents another challenge. The majority of the studies identified through this review focus on only a subset of species, subtypes and genes, such as influenza in avian species and avian influenza viruses adapting to humans, especially in the context of highly pathogenic avian influenza H5N1. Further research applying a holistic approach and investigating the broader influenza genetic spectrum is urgently needed in the field of genetic adaptation of influenza A viruses.
Keywords
PANDEMIC H1N1 VIRUS, CANINE INFLUENZA, TO-HUMAN TRANSMISSION, NATURAL CONTACT EXPOSURE, RECEPTOR-BINDING PROPERTIES, RESPIRATORY EPITHELIAL-CELLS, PATHOGENIC AVIAN INFLUENZA, dogs, horses, swine, poultry, adaptation, influenza, SWINE INFLUENZA, H5N1 VIRUSES, HUMAN INFECTION

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Citation

Please use this url to cite or link to this publication:

Chicago
Munoz, Olga, Marco De Nardi, Karen van der Meulen, Kristien Van Reeth, Marion Koopmans, Kate Harris, Sophie von Dobschuetz, et al. 2016. “Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission : a Literature Review.” Ecohealth 13 (1): 171–198.
APA
Munoz, O., De Nardi, M., van der Meulen, K., Van Reeth, K., Koopmans, M., Harris, K., von Dobschuetz, S., et al. (2016). Genetic adaptation of influenza A viruses in domestic animals and their potential role in interspecies transmission : a literature review. ECOHEALTH, 13(1), 171–198.
Vancouver
1.
Munoz O, De Nardi M, van der Meulen K, Van Reeth K, Koopmans M, Harris K, et al. Genetic adaptation of influenza A viruses in domestic animals and their potential role in interspecies transmission : a literature review. ECOHEALTH. 2016;13(1):171–98.
MLA
Munoz, Olga, Marco De Nardi, Karen van der Meulen, et al. “Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission : a Literature Review.” ECOHEALTH 13.1 (2016): 171–198. Print.
@article{8032350,
  abstract     = {In December 2011, the European Food Safety Authority awarded a Grant for the implementation of the FLURISK project. The main objective of FLURISK was the development of an epidemiological and virological evidence-based influenza risk assessment framework (IRAF) to assess influenza A virus strains circulating in the animal population according to their potential to cross the species barrier and cause infections in humans. With the purpose of gathering virological data to include in the IRAF, a literature review was conducted and key findings are presented here. Several adaptive traits have been identified in influenza viruses infecting domestic animals and a significance of these adaptations for the emergence of zoonotic influenza, such as shift in receptor preference and mutations in the replication proteins, has been hypothesized. Nonetheless, and despite several decades of research, a comprehensive understanding of the conditions that facilitate interspecies transmission is still lacking. This has been hampered by the intrinsic difficulties of the subject and the complexity of correlating environmental, viral and host factors. Finding the most suitable and feasible way of investigating these factors in laboratory settings represents another challenge. The majority of the studies identified through this review focus on only a subset of species, subtypes and genes, such as influenza in avian species and avian influenza viruses adapting to humans, especially in the context of highly pathogenic avian influenza H5N1. Further research applying a holistic approach and investigating the broader influenza genetic spectrum is urgently needed in the field of genetic adaptation of influenza A viruses.},
  author       = {Munoz, Olga and De Nardi, Marco and van der Meulen, Karen and Van Reeth, Kristien and Koopmans, Marion and Harris, Kate and von Dobschuetz, Sophie and Freidl, Gudrun and Meijer, Adam and Breed, Andrew C and Hill, Andrew and Kosmider, Rowena and Banks, Jill and Stark, Katharina DC and Wieland, Barbara and Stevens, Kim and van der Werf, Sylvie and Enouf, Vincent and Dauphin, Gwenaele and Dundon, William and Cattoli, Giovanni and Capua, Ilaria},
  issn         = {1612-9202},
  journal      = {ECOHEALTH},
  language     = {eng},
  number       = {1},
  pages        = {171--198},
  title        = {Genetic adaptation of influenza A viruses in domestic animals and their potential role in interspecies transmission : a literature review},
  url          = {http://dx.doi.org/10.1007/s10393-014-1004-1},
  volume       = {13},
  year         = {2016},
}

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