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The mechanism of pseudorabies virus US3-mediated actin rearrangements

Celine Van den Broeke UGent (2009)
abstract
The alphaherpesvirus US3 kinase is a conserved multifunctional serine/threonine kinase that plays a role in regulating actin dynamics, egress of virus particles from the nucleus and apoptosis. However, the mechanisms used by the US3 protein to exert its functions remain poorly understood. Recently, we identified group A p21-activated kinases as important effectors in the US3-mediated cytoskeletal rearrangements. Here, we investigated if these PAKs are also involved in the other functions of US3. We report that group A PAKs only play a minor role in US3-mediated effects on apoptosis. On the other hand, we identified PAK2 as an important protein in the US3-assisted export of progeny virus from the nucleus, pointing at a possible novel role for PAK2 in nuclear export and suggesting that PAK2 may also be involved in US3-independent processes in the nucleus.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
pages
202 pages
publisher
Ghent University. Faculty of Veterinary Medicine
place of publication
Merelbeke, Belgium
defense location
Merelbeke : Faculteit Diergeneeskunde (auditorium D)
defense date
2009-11-30 16:30
ISBN
9789058641885
language
English
UGent publication?
yes
classification
D1
additional info
dissertation in parts contains copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
803232
handle
http://hdl.handle.net/1854/LU-803232
date created
2009-12-08 14:14:45
date last changed
2010-03-05 11:26:50
@phdthesis{803232,
  abstract     = {The alphaherpesvirus US3 kinase is a conserved multifunctional serine/threonine kinase that plays a role in regulating actin dynamics, egress of virus particles from the nucleus and apoptosis. However, the mechanisms used by the US3 protein to exert its functions remain poorly understood. Recently, we identified group A p21-activated kinases as important effectors in the US3-mediated cytoskeletal rearrangements. Here, we investigated if these PAKs are also involved in the other functions of US3. We report that group A PAKs only play a minor role in US3-mediated effects on apoptosis. On the other hand, we identified PAK2 as an important protein in the US3-assisted export of progeny virus from the nucleus, pointing at a possible novel role for PAK2 in nuclear export and suggesting that PAK2 may also be involved in US3-independent processes in the nucleus.},
  author       = {Van den Broeke, Celine},
  isbn         = {9789058641885},
  language     = {eng},
  pages        = {202},
  publisher    = {Ghent University. Faculty of Veterinary Medicine},
  school       = {Ghent University},
  title        = {The mechanism of pseudorabies virus US3-mediated actin rearrangements},
  year         = {2009},
}

Chicago
Van den Broeke, Celine. 2009. “The Mechanism of Pseudorabies Virus US3-mediated Actin Rearrangements”. Merelbeke, Belgium: Ghent University. Faculty of Veterinary Medicine.
APA
Van den Broeke, C. (2009). The mechanism of pseudorabies virus US3-mediated actin rearrangements. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vancouver
1.
Van den Broeke C. The mechanism of pseudorabies virus US3-mediated actin rearrangements. [Merelbeke, Belgium]: Ghent University. Faculty of Veterinary Medicine; 2009.
MLA
Van den Broeke, Celine. “The Mechanism of Pseudorabies Virus US3-mediated Actin Rearrangements.” 2009 : n. pag. Print.