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Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus

(2009) JOURNAL OF IMMUNOLOGY. 183(4). p.2213-2216
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Abstract
The current model used to define T cell export from the thymus suggests that emigrating lymphocytes seed the peripheral organs as functionally mature cells. This model holds true for the majority of T cells exported from the thymus with the exception of invariant NK T (iNKT) cells. iNKT cells undergo lineage expansion after positive selection and acquire NK receptor expression once fully mature; yet, the majority of mature iNKT cells are retained in the thymus by an as of yet unidentified mechanism. In this study we demonstrate that mature iNKT cells are retained in the thymus by the chemokine receptor CXCR3. We propose that the expression of CXCR3 ligands in the thymic medullary epithelium promotes the chemotactic retention of mature iNKT thymocytes and prevents leakage of iNKT cells into the peripheral circulation.

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Chicago
Drennan, Michael, ANN-SOPHIE FRANKI, Pieter Dewint, Katrien Van Beneden, Sylvie Seeuws, Serge van de Pavert, Emma Reilly, et al. 2009. “Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus.” Journal of Immunology 183 (4): 2213–2216.
APA
Drennan, M., FRANKI, A.-S., Dewint, P., Van Beneden, K., Seeuws, S., van de Pavert, S., Reilly, E., et al. (2009). Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus. JOURNAL OF IMMUNOLOGY, 183(4), 2213–2216.
Vancouver
1.
Drennan M, FRANKI A-S, Dewint P, Van Beneden K, Seeuws S, van de Pavert S, et al. Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus. JOURNAL OF IMMUNOLOGY. 2009;183(4):2213–6.
MLA
Drennan, Michael, ANN-SOPHIE FRANKI, Pieter Dewint, et al. “Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus.” JOURNAL OF IMMUNOLOGY 183.4 (2009): 2213–2216. Print.
@article{802998,
  abstract     = {The current model used to define T cell export from the thymus suggests that emigrating lymphocytes seed the peripheral organs as functionally mature cells. This model holds true for the majority of T cells exported from the thymus with the exception of invariant NK T (iNKT) cells. iNKT cells undergo lineage expansion after positive selection and acquire NK receptor expression once fully mature; yet, the majority of mature iNKT cells are retained in the thymus by an as of yet unidentified mechanism. In this study we demonstrate that mature iNKT cells are retained in the thymus by the chemokine receptor CXCR3. We propose that the expression of CXCR3 ligands in the thymic medullary epithelium promotes the chemotactic retention of mature iNKT thymocytes and prevents leakage of iNKT cells into the peripheral circulation.},
  author       = {Drennan, Michael and FRANKI, ANN-SOPHIE and Dewint, Pieter and Van Beneden, Katrien and Seeuws, Sylvie and van de Pavert, Serge and Reilly, Emma and Verbruggen, Gust and Lane, Thomas and Mebius, Reina and Deforce, Dieter and Elewaut, Dirk},
  issn         = {0022-1767},
  journal      = {JOURNAL OF IMMUNOLOGY},
  language     = {eng},
  number       = {4},
  pages        = {2213--2216},
  title        = {Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus},
  url          = {http://dx.doi.org/10.4049/jimmunol.0901213},
  volume       = {183},
  year         = {2009},
}

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