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Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus

Arno Vermote (UGent) , Gilles Brackman (UGent) , Martijn Risseeuw (UGent) , Bieke Vanhoutte, Paul Cos, Kristof Van Hecke (UGent) , Koen Breyne (UGent) , Evelyne Meyer (UGent) , Tom Coenye (UGent) and Serge Van Calenbergh (UGent)
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Abstract
The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans, and in a mouse mammary gland infection model, without showing cytotoxicity.
Keywords
biofilms, antibiotics, MRSA, potentiators, quorum sensing, INFECTIONS, SUSCEPTIBILITY, RESISTANCE, DISCOVERY, INHIBITOR, BIOFILMS

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MLA
Vermote, Arno et al. “Hamamelitannin Analogues That Modulate Quorum Sensing as Potentiators of Antibiotics Against Staphylococcus Aureus.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.22 (2016): 6551–6555. Print.
APA
Vermote, A., Brackman, G., Risseeuw, M., Vanhoutte, B., Cos, P., Van Hecke, K., Breyne, K., et al. (2016). Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 55(22), 6551–6555.
Chicago author-date
Vermote, Arno, Gilles Brackman, Martijn Risseeuw, Bieke Vanhoutte, Paul Cos, Kristof Van Hecke, Koen Breyne, Evelyne Meyer, Tom Coenye, and Serge Van Calenbergh. 2016. “Hamamelitannin Analogues That Modulate Quorum Sensing as Potentiators of Antibiotics Against Staphylococcus Aureus.” Angewandte Chemie-international Edition 55 (22): 6551–6555.
Chicago author-date (all authors)
Vermote, Arno, Gilles Brackman, Martijn Risseeuw, Bieke Vanhoutte, Paul Cos, Kristof Van Hecke, Koen Breyne, Evelyne Meyer, Tom Coenye, and Serge Van Calenbergh. 2016. “Hamamelitannin Analogues That Modulate Quorum Sensing as Potentiators of Antibiotics Against Staphylococcus Aureus.” Angewandte Chemie-international Edition 55 (22): 6551–6555.
Vancouver
1.
Vermote A, Brackman G, Risseeuw M, Vanhoutte B, Cos P, Van Hecke K, et al. Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2016;55(22):6551–5.
IEEE
[1]
A. Vermote et al., “Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus,” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 55, no. 22, pp. 6551–6555, 2016.
@article{8028898,
  abstract     = {The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans, and in a mouse mammary gland infection model, without showing cytotoxicity.},
  author       = {Vermote, Arno and Brackman, Gilles and Risseeuw, Martijn and Vanhoutte, Bieke and Cos, Paul and Van Hecke, Kristof and Breyne, Koen and Meyer, Evelyne and Coenye, Tom and Van Calenbergh, Serge},
  issn         = {1433-7851},
  journal      = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},
  keywords     = {biofilms,antibiotics,MRSA,potentiators,quorum sensing,INFECTIONS,SUSCEPTIBILITY,RESISTANCE,DISCOVERY,INHIBITOR,BIOFILMS},
  language     = {eng},
  number       = {22},
  pages        = {6551--6555},
  title        = {Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus},
  url          = {http://dx.doi.org/10.1002/anie.201601973},
  volume       = {55},
  year         = {2016},
}

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