Freeze-dried polymer-coated quantum dots for perspective biomedical application
- Author
- Valentina Goftman (UGent) , Anna V Gaynbuch, Elizaveta V Panfilova, Boris N Khlebtsov and Irina Yu Goryasheva
- Organization
- Abstract
- Freeze-drying as known as lyophilization has been considered as a possible technique to improve the long-term stability of colloidal luminescent quantum dots (QDs) for perspective biomedical application. The paper describes synthesis of biocompatible CdSe-based core/ shell QDs and discusses their optical and physical properties before and after freeze-drying. Importantly, the dried nanoparticles can be stored for a long time under usual conditions and then can easily be redisperse in water at a desired concentration without such hard manipulations as sonication or heating. In this work two PEG-amine derivatives were applied for QDs pegylation: monoamine Jeffamine M1000 and diamine JeffamineED-2003. The use of different Jeffamines allows us to obtain QDs with different length of PEG chains and different zeta-potential. The influence of polymer composition on optical properties of the nanocrystals and on their stability after freeze-drying was studied.
- Keywords
- freeze-drying, THERAPY, NANOPARTICLE, TOXICITY, TUMORS, quantum dots (QDs), polyethyleneglycol (PEG), ζ-potential, sentinel lymph nodes
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8028394
- MLA
- Goftman, Valentina, et al. “Freeze-Dried Polymer-Coated Quantum Dots for Perspective Biomedical Application.” Proceedings of SPIE, edited by Elina A Genina et al., vol. 9448, SPIE-International Society for Optical Engineering, 2015, doi:10.1117/12.2178368.
- APA
- Goftman, V., Gaynbuch, A. V., Panfilova, E. V., Khlebtsov, B. N., & Goryasheva, I. Y. (2015). Freeze-dried polymer-coated quantum dots for perspective biomedical application. In E. A. Genina, V. L. Derbov, K. V. Larin, D. E. Postnov, & V. V. Tuchin (Eds.), Proceedings of SPIE (Vol. 9448). https://doi.org/10.1117/12.2178368
- Chicago author-date
- Goftman, Valentina, Anna V Gaynbuch, Elizaveta V Panfilova, Boris N Khlebtsov, and Irina Yu Goryasheva. 2015. “Freeze-Dried Polymer-Coated Quantum Dots for Perspective Biomedical Application.” In Proceedings of SPIE, edited by Elina A Genina, Vladimir L Derbov, Kirill V Larin, Dmitry E Postnov, and Valery V Tuchin. Vol. 9448. Bellingham, WA, USA: SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2178368.
- Chicago author-date (all authors)
- Goftman, Valentina, Anna V Gaynbuch, Elizaveta V Panfilova, Boris N Khlebtsov, and Irina Yu Goryasheva. 2015. “Freeze-Dried Polymer-Coated Quantum Dots for Perspective Biomedical Application.” In Proceedings of SPIE, ed by. Elina A Genina, Vladimir L Derbov, Kirill V Larin, Dmitry E Postnov, and Valery V Tuchin. Vol. 9448. Bellingham, WA, USA: SPIE-International Society for Optical Engineering. doi:10.1117/12.2178368.
- Vancouver
- 1.Goftman V, Gaynbuch AV, Panfilova EV, Khlebtsov BN, Goryasheva IY. Freeze-dried polymer-coated quantum dots for perspective biomedical application. In: Genina EA, Derbov VL, Larin KV, Postnov DE, Tuchin VV, editors. Proceedings of SPIE. Bellingham, WA, USA: SPIE-International Society for Optical Engineering; 2015.
- IEEE
- [1]V. Goftman, A. V. Gaynbuch, E. V. Panfilova, B. N. Khlebtsov, and I. Y. Goryasheva, “Freeze-dried polymer-coated quantum dots for perspective biomedical application,” in Proceedings of SPIE, Saratov, Russian Federation, 2015, vol. 9448.
@inproceedings{8028394,
abstract = {{Freeze-drying as known as lyophilization has been considered as a possible technique to improve the long-term stability of colloidal luminescent quantum dots (QDs) for perspective biomedical application. The paper describes synthesis of biocompatible CdSe-based core/ shell QDs and discusses their optical and physical properties before and after freeze-drying. Importantly, the dried nanoparticles can be stored for a long time under usual conditions and then can easily be redisperse in water at a desired concentration without such hard manipulations as sonication or heating. In this work two PEG-amine derivatives were applied for QDs pegylation: monoamine Jeffamine M1000 and diamine JeffamineED-2003. The use of different Jeffamines allows us to obtain QDs with different length of PEG chains and different zeta-potential. The influence of polymer composition on optical properties of the nanocrystals and on their stability after freeze-drying was studied.}},
articleno = {{94480X}},
author = {{Goftman, Valentina and Gaynbuch, Anna V and Panfilova, Elizaveta V and Khlebtsov, Boris N and Goryasheva, Irina Yu}},
booktitle = {{Proceedings of SPIE}},
editor = {{Genina, Elina A and Derbov, Vladimir L and Larin, Kirill V and Postnov, Dmitry E and Tuchin, Valery V}},
isbn = {{9781628415643}},
issn = {{0277-786X}},
keywords = {{freeze-drying,THERAPY,NANOPARTICLE,TOXICITY,TUMORS,quantum dots (QDs),polyethyleneglycol (PEG),ζ-potential,sentinel lymph nodes}},
language = {{eng}},
location = {{Saratov, Russian Federation}},
pages = {{7}},
publisher = {{SPIE-International Society for Optical Engineering}},
title = {{Freeze-dried polymer-coated quantum dots for perspective biomedical application}},
url = {{http://doi.org/10.1117/12.2178368}},
volume = {{9448}},
year = {{2015}},
}
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