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Clinical and MRI outcome of an osteochondral scaffold plug for the treatment of cartilage lesions in the knee

Aad Dhollander, Peter Verdonk (UGent) , Karl Almqvist (UGent) , René Verdonk (UGent) and Jan Victor (UGent)
(2015) ACTA ORTHOPAEDICA BELGICA. 81(4). p.629-638
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Abstract
Conflicting clinical outcomes have been reported recently with the use of an osteochondral scaffold plugs for cartilage repair in the knee. In this study, twenty patients were consecutively treated for their cartilage lesions with the synthetic plug technique. These patients were prospectively clinically evaluated with a mean follow-up of 34.15 months. Magnetic resonance imaging (MRI) was used for morphologic analysis of the cartilage repair. The patients included in this study showed a significant gradual clinical improvement after the osteochondral scaffold plug. However, this clinical improvement was not confirmed by the MRI findings of this cohort study. Subchondral bone changes were seen in all patients on MRI and deficient filling of the defect was noticed in in 30.7% of the cases at 24 months of follow-up. There was no evidence found to support osteoconductive bone ingrowth. Therefore, the use of this type of osteochondral scaffold plug in osteochondral repair is questionable.
Keywords
cartilage, knee, osteochondral, scaffolds, AUTOLOGOUS CHONDROCYTE TRANSPLANTATION, VISUAL ANALOG SCALE, ARTICULAR-CARTILAGE, REPAIR TISSUE, SCORE KOOS, DEFECTS, INJURY, BONE, REGENERATION, IMPLANTATION

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Citation

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Chicago
Dhollander, Aad, Peter Verdonk, Karl Almqvist, René Verdonk, and Jan Victor. 2015. “Clinical and MRI Outcome of an Osteochondral Scaffold Plug for the Treatment of Cartilage Lesions in the Knee.” Acta Orthopaedica Belgica 81 (4): 629–638.
APA
Dhollander, A., Verdonk, P., Almqvist, K., Verdonk, R., & Victor, J. (2015). Clinical and MRI outcome of an osteochondral scaffold plug for the treatment of cartilage lesions in the knee. ACTA ORTHOPAEDICA BELGICA, 81(4), 629–638.
Vancouver
1.
Dhollander A, Verdonk P, Almqvist K, Verdonk R, Victor J. Clinical and MRI outcome of an osteochondral scaffold plug for the treatment of cartilage lesions in the knee. ACTA ORTHOPAEDICA BELGICA. 2015;81(4):629–38.
MLA
Dhollander, Aad, Peter Verdonk, Karl Almqvist, et al. “Clinical and MRI Outcome of an Osteochondral Scaffold Plug for the Treatment of Cartilage Lesions in the Knee.” ACTA ORTHOPAEDICA BELGICA 81.4 (2015): 629–638. Print.
@article{8028018,
  abstract     = {Conflicting clinical outcomes have been reported recently with the use of an osteochondral scaffold plugs for cartilage repair in the knee. In this study, twenty patients were consecutively treated for their cartilage lesions with the synthetic plug technique. These patients were prospectively clinically evaluated with a mean follow-up of 34.15 months. Magnetic resonance imaging (MRI) was used for morphologic analysis of the cartilage repair. The patients included in this study showed a significant gradual clinical improvement after the osteochondral scaffold plug. However, this clinical improvement was not confirmed by the MRI findings of this cohort study. Subchondral bone changes were seen in all patients on MRI and deficient filling of the defect was noticed in in 30.7\% of the cases at 24 months of follow-up. There was no evidence found to support osteoconductive bone ingrowth. Therefore, the use of this type of osteochondral scaffold plug in osteochondral repair is questionable.},
  author       = {Dhollander, Aad and Verdonk, Peter and Almqvist, Karl and Verdonk, Ren{\'e} and Victor, Jan},
  issn         = {0001-6462},
  journal      = {ACTA ORTHOPAEDICA BELGICA},
  keyword      = {cartilage,knee,osteochondral,scaffolds,AUTOLOGOUS CHONDROCYTE TRANSPLANTATION,VISUAL ANALOG SCALE,ARTICULAR-CARTILAGE,REPAIR TISSUE,SCORE KOOS,DEFECTS,INJURY,BONE,REGENERATION,IMPLANTATION},
  language     = {eng},
  number       = {4},
  pages        = {629--638},
  title        = {Clinical and MRI outcome of an osteochondral scaffold plug for the treatment of cartilage lesions in the knee},
  volume       = {81},
  year         = {2015},
}

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