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Association of recently described adipokines with liver histology in biopsy-proven non-alcoholic fatty liver disease: a systematic review

Marlies Bekaert (UGent) , Xavier Verhelst (UGent) , Anja Geerts (UGent) , Bruno Lapauw (UGent) and Patrick Calders (UGent)
(2016) OBESITY REVIEWS. 17(1). p.68-80
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Abstract
The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising, as is the prevalence of obesity and type 2 diabetes. It is increasingly recognized that an impaired pattern in adipokine secretion could play a pivotal role in the development of NAFLD. We performed a systematic review to evaluate the potential link between newly described adipokines and liver histology in biopsy-proven NAFLD patients. A computerized literature search was performed in PubMed, EMBASE and Web of Science electronic databases. Thirty-one cross-sectional studies were included, resulting in a total of seven different investigated adipokines. Studies included in this review mainly had a goodmethodological quality. Most adipokineswere suggested to be involved in the inflammatory response that developswithin the context ofNAFLD, either at hepatic or systemic level, and/or hepatic insulin resistance. Based on literature, clinical studies suggest that chemerin, resistin and adipocyte-fatty-acid-binding protein potentially are involved in NAFLD pathogenesis and/or progression. However, major inconsistency still exists, and there is a high need for larger studies, together with the need of standardized assays to determine adipokine levels.
Keywords
insulin resistance, Adipokines, liver histology, non-alcoholic fatty liver disease, ACID-BINDING PROTEIN, MONOCYTE CHEMOATTRACTANT PROTEIN-1, MORBIDLY OBESE-PATIENTS, HEPATIC STELLATE CELLS, HUMAN ADIPOSE-TISSUE, INSULIN-RESISTANCE, METABOLIC SYNDROME, NATURAL-HISTORY, GENE-EXPRESSION, WEIGHT-LOSS

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Chicago
BEKAERT, MARLIES, Xavier Verhelst, Anja Geerts, Bruno Lapauw, and Patrick Calders. 2016. “Association of Recently Described Adipokines with Liver Histology in Biopsy-proven Non-alcoholic Fatty Liver Disease: a Systematic Review.” Obesity Reviews 17 (1): 68–80.
APA
BEKAERT, M., Verhelst, X., Geerts, A., Lapauw, B., & Calders, P. (2016). Association of recently described adipokines with liver histology in biopsy-proven non-alcoholic fatty liver disease: a systematic review. OBESITY REVIEWS, 17(1), 68–80.
Vancouver
1.
BEKAERT M, Verhelst X, Geerts A, Lapauw B, Calders P. Association of recently described adipokines with liver histology in biopsy-proven non-alcoholic fatty liver disease: a systematic review. OBESITY REVIEWS. 2016;17(1):68–80.
MLA
BEKAERT, MARLIES, Xavier Verhelst, Anja Geerts, et al. “Association of Recently Described Adipokines with Liver Histology in Biopsy-proven Non-alcoholic Fatty Liver Disease: a Systematic Review.” OBESITY REVIEWS 17.1 (2016): 68–80. Print.
@article{8023360,
  abstract     = {The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising, as is the prevalence of obesity and type 2 diabetes. It is increasingly recognized that an impaired pattern in adipokine secretion could play a pivotal role in the development of NAFLD. We performed a systematic review to evaluate the potential link between newly described adipokines and liver histology in biopsy-proven NAFLD patients. A computerized literature search was performed in PubMed, EMBASE and Web of Science electronic databases. Thirty-one cross-sectional studies were included, resulting in a total of seven different investigated adipokines. Studies included in this review mainly had a goodmethodological quality. Most adipokineswere suggested to be involved in the inflammatory response that developswithin the context ofNAFLD, either at hepatic or systemic level, and/or hepatic insulin resistance. Based on literature, clinical studies suggest that chemerin, resistin and adipocyte-fatty-acid-binding protein potentially are involved in NAFLD pathogenesis and/or progression. However, major inconsistency still exists, and there is a high need for larger studies, together with the need of standardized assays to determine adipokine levels.},
  author       = {Bekaert, Marlies and Verhelst, Xavier and Geerts, Anja and Lapauw, Bruno and Calders, Patrick},
  issn         = {1467-7881},
  journal      = {OBESITY REVIEWS},
  keyword      = {insulin resistance,Adipokines,liver histology,non-alcoholic fatty liver disease,ACID-BINDING PROTEIN,MONOCYTE CHEMOATTRACTANT PROTEIN-1,MORBIDLY OBESE-PATIENTS,HEPATIC STELLATE CELLS,HUMAN ADIPOSE-TISSUE,INSULIN-RESISTANCE,METABOLIC SYNDROME,NATURAL-HISTORY,GENE-EXPRESSION,WEIGHT-LOSS},
  language     = {eng},
  number       = {1},
  pages        = {68--80},
  title        = {Association of recently described adipokines with liver histology in biopsy-proven non-alcoholic fatty liver disease: a systematic review},
  url          = {http://dx.doi.org/10.1111/obr.12333},
  volume       = {17},
  year         = {2016},
}

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