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Transcranial magnetic stimulation in Doberman Pinschers with clinically relevant and clinically irrelevant spinal cord compression on magnetic resonance imaging

Steven De Decker UGent, Iris Van Soens UGent, Luc Duchateau UGent, Ingrid Gielen UGent, Henri van Bree UGent, Dominique Binst UGent, Tim Waelbers UGent and Luc Van Ham UGent (2011) JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION. 238(1). p.81-88
abstract
Objective: To evaluate the use of transcranial magnetic stimulation for differentiating between clinically relevant and clinically irrelevant cervical spinal cord compression on magnetic resonance imaging (MRI). Design: Validation study. Animals: Clinically normal Doberman Pinschers without (n = 11) and with (6) spinal cord compression on MRI and 16 Doberman Pinschers with disk-associated wobbler syndrome (DAWS). Procedures: After dogs were sedated, transcranial magnetic motor evoked potentials were recorded from the extensor carpi radialis muscle (ECRM) and cranial tibial muscle (CTM). Onset latencies and peak-to-peak amplitudes were measured. Magnetic resonance imaging was performed to identify spinal cord compression. Results: There were significant differences in ECRM and CTM onset latencies between Doberman Pinschers with DAWS and each of the 2 groups of clinically normal dogs, but there were no significant differences in ECRM and CTM onset latencies between the 2 groups of clinically normal dogs. There were significant differences in CTM peak-to-peak amplitudes between Doberman Pinschers with DAWS and each of the 2 groups of clinically normal dogs, but there were no significant differences in ECRM peak-to-peak amplitudes among groups or in CTM peak-to-peak amplitudes between the 2 groups of clinically normal dogs. There was a significant correlation between severity of spinal cord compression and ECRM onset latency, CTM onset latency, and CTM peak-to-peak amplitude. Conclusions and Clinical Relevance :Results suggested that transcranial magnetic stimulation may be a useful diagnostic tool to differentiate between clinically relevant and clinically irrelevant spinal cord compression identified on MRI alone.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SPONDYLOMYELOPATHY, CORTEX, HORSES, DOGS, DISK DISEASE, ASYMPTOMATIC SUBJECTS, MOTOR-EVOKED-POTENTIALS, CERVICAL SPONDYLOTIC MYELOPATHY, SIGNS, PRINCIPLES
journal title
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
JAVMA-J. Am. Vet. Med. Assoc.
volume
238
issue
1
pages
81 - 88
Web of Science type
Article
Web of Science id
000285669400021
JCR category
VETERINARY SCIENCES
JCR impact factor
1.791 (2011)
JCR rank
23/141 (2011)
JCR quartile
1 (2011)
ISSN
0003-1488
DOI
10.2460/javma.238.1.81
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
798891
handle
http://hdl.handle.net/1854/LU-798891
date created
2009-12-03 16:51:40
date last changed
2011-07-06 16:10:39
@article{798891,
  abstract     = {Objective: To evaluate the use of transcranial magnetic stimulation for differentiating between clinically relevant and clinically irrelevant cervical spinal cord compression on magnetic resonance imaging (MRI).
Design: Validation study.
Animals: Clinically normal Doberman Pinschers without (n = 11) and with (6) spinal cord compression on MRI and 16 Doberman Pinschers with disk-associated wobbler syndrome (DAWS).
Procedures: After dogs were sedated, transcranial magnetic motor evoked potentials were recorded from the extensor carpi radialis muscle (ECRM) and cranial tibial muscle (CTM). Onset latencies and peak-to-peak amplitudes were measured. Magnetic resonance imaging was performed to identify spinal cord compression.
Results: There were significant differences in ECRM and CTM onset latencies between Doberman Pinschers with DAWS and each of the 2 groups of clinically normal dogs, but there were no significant differences in ECRM and CTM onset latencies between the 2 groups of clinically normal dogs. There were significant differences in CTM peak-to-peak amplitudes between Doberman Pinschers with DAWS and each of the 2 groups of clinically normal dogs, but there were no significant differences in ECRM peak-to-peak amplitudes among groups or in CTM peak-to-peak amplitudes between the 2 groups of clinically normal dogs. There was a significant correlation between severity of spinal cord compression and ECRM onset latency, CTM onset latency, and CTM peak-to-peak amplitude.
Conclusions and Clinical Relevance :Results suggested that transcranial magnetic stimulation may be a useful diagnostic tool to differentiate between clinically relevant and clinically irrelevant spinal cord compression identified on MRI alone.},
  author       = {De Decker, Steven and Van Soens, Iris and Duchateau, Luc and Gielen, Ingrid and van Bree, Henri and Binst, Dominique and Waelbers, Tim and Van Ham, Luc},
  issn         = {0003-1488},
  journal      = {JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION},
  keyword      = {SPONDYLOMYELOPATHY,CORTEX,HORSES,DOGS,DISK DISEASE,ASYMPTOMATIC SUBJECTS,MOTOR-EVOKED-POTENTIALS,CERVICAL SPONDYLOTIC MYELOPATHY,SIGNS,PRINCIPLES},
  language     = {eng},
  number       = {1},
  pages        = {81--88},
  title        = {Transcranial magnetic stimulation in Doberman Pinschers with clinically relevant and clinically irrelevant spinal cord compression on magnetic resonance imaging},
  url          = {http://dx.doi.org/10.2460/javma.238.1.81},
  volume       = {238},
  year         = {2011},
}

Chicago
De Decker, Steven, Iris Van Soens, Luc Duchateau, Ingrid Gielen, Henri van Bree, Dominique Binst, Tim Waelbers, and Luc Van Ham. 2011. “Transcranial Magnetic Stimulation in Doberman Pinschers with Clinically Relevant and Clinically Irrelevant Spinal Cord Compression on Magnetic Resonance Imaging.” Javma-journal of the American Veterinary Medical Association 238 (1): 81–88.
APA
De Decker, S., Van Soens, I., Duchateau, L., Gielen, I., van Bree, H., Binst, D., Waelbers, T., et al. (2011). Transcranial magnetic stimulation in Doberman Pinschers with clinically relevant and clinically irrelevant spinal cord compression on magnetic resonance imaging. JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 238(1), 81–88.
Vancouver
1.
De Decker S, Van Soens I, Duchateau L, Gielen I, van Bree H, Binst D, et al. Transcranial magnetic stimulation in Doberman Pinschers with clinically relevant and clinically irrelevant spinal cord compression on magnetic resonance imaging. JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION. 2011;238(1):81–8.
MLA
De Decker, Steven, Iris Van Soens, Luc Duchateau, et al. “Transcranial Magnetic Stimulation in Doberman Pinschers with Clinically Relevant and Clinically Irrelevant Spinal Cord Compression on Magnetic Resonance Imaging.” JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION 238.1 (2011): 81–88. Print.