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Biology of lung dendritic cells at the origin of asthma

Bart Lambrecht UGent and Hamida Hammad UGent (2009) IMMUNITY. 31(3). p.412-424
abstract
Dendritic cells (DCs) initiate and maintain adaptive T helper 2 (Th2) cell responses to inhaled allergens in asthma. Various functions like antigen uptake, migration to the draining LNs, and induction of tolerance and adaptive immunity are not equally shared by all subsets of DCs, adding considerable complexity to understanding the immunology of allergic sensitization. Whereas the epithelium was initially considered solely as a physical barrier, it is now seen as a central player in controlling the function of lung DCs through release of Th2 cell-promoting cytokines. Although DCs are sufficient and necessary for induction of Th2 cell responses to many antigens, some allergens might require antigen presentation by basophils. Clinically relevant allergens, as well as environmental and genetic risk factors for allergy and asthma, often interfere directly or indirectly with the innate immune functions of airway epithelial cells, basophils, and DCs. This review summarizes the recent progress on our understanding how DCs control Th2 cell immunity in the lung.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
epithelial-cells, allergic airway inflammation, House-dust mite, antigen-presenting cells, Th2 responses, blood monocyte subsets, inhaled antigen, CD4(+) T-cells, respiratory syncytial virus, immune-responses, HOUSE-DUST MITE, ALLERGIC AIRWAY INFLAMMATION, CD4(+) T-CELLS, RESPIRATORY SYNCYTIAL VIRUS, ANTIGEN-PRESENTING CELLS, BLOOD MONOCYTE SUBSETS, EPITHELIAL-CELLS, IMMUNE-RESPONSES, INHALED ANTIGEN, TH2 RESPONSES
journal title
IMMUNITY
Immunity
volume
31
issue
3
pages
412 - 424
Web of Science type
Review
Web of Science id
000270525900007
JCR category
IMMUNOLOGY
JCR impact factor
20.589 (2009)
JCR rank
4/126 (2009)
JCR quartile
1 (2009)
ISSN
1074-7613
DOI
10.1016/j.immuni.2009.08.008
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
798016
handle
http://hdl.handle.net/1854/LU-798016
date created
2009-12-02 15:36:54
date last changed
2016-12-19 15:42:42
@article{798016,
  abstract     = {Dendritic cells (DCs) initiate and maintain adaptive T helper 2 (Th2) cell responses to inhaled allergens in asthma. Various functions like antigen uptake, migration to the draining LNs, and induction of tolerance and adaptive immunity are not equally shared by all subsets of DCs, adding considerable complexity to understanding the immunology of allergic sensitization. Whereas the epithelium was initially considered solely as a physical barrier, it is now seen as a central player in controlling the function of lung DCs through release of Th2 cell-promoting cytokines. Although DCs are sufficient and necessary for induction of Th2 cell responses to many antigens, some allergens might require antigen presentation by basophils. Clinically relevant allergens, as well as environmental and genetic risk factors for allergy and asthma, often interfere directly or indirectly with the innate immune functions of airway epithelial cells, basophils, and DCs. This review summarizes the recent progress on our understanding how DCs control Th2 cell immunity in the lung.},
  author       = {Lambrecht, Bart and Hammad, Hamida},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keyword      = {epithelial-cells,allergic airway inflammation,House-dust mite,antigen-presenting cells,Th2 responses,blood monocyte subsets,inhaled antigen,CD4(+) T-cells,respiratory syncytial virus,immune-responses,HOUSE-DUST MITE,ALLERGIC AIRWAY INFLAMMATION,CD4(+) T-CELLS,RESPIRATORY SYNCYTIAL VIRUS,ANTIGEN-PRESENTING CELLS,BLOOD MONOCYTE SUBSETS,EPITHELIAL-CELLS,IMMUNE-RESPONSES,INHALED ANTIGEN,TH2 RESPONSES},
  language     = {eng},
  number       = {3},
  pages        = {412--424},
  title        = {Biology of lung dendritic cells at the origin of asthma},
  url          = {http://dx.doi.org/10.1016/j.immuni.2009.08.008},
  volume       = {31},
  year         = {2009},
}

Chicago
Lambrecht, Bart, and Hamida Hammad. 2009. “Biology of Lung Dendritic Cells at the Origin of Asthma.” Immunity 31 (3): 412–424.
APA
Lambrecht, Bart, & Hammad, H. (2009). Biology of lung dendritic cells at the origin of asthma. IMMUNITY, 31(3), 412–424.
Vancouver
1.
Lambrecht B, Hammad H. Biology of lung dendritic cells at the origin of asthma. IMMUNITY. 2009;31(3):412–24.
MLA
Lambrecht, Bart, and Hamida Hammad. “Biology of Lung Dendritic Cells at the Origin of Asthma.” IMMUNITY 31.3 (2009): 412–424. Print.