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In vivo evaluation of the vaginal distribution and retention of a multi-particulate pellet formulation

Nele Poelvoorde UGent, Hans Verstraelen UGent, Rita Verhelst UGent, Bart Saerens UGent, Ellen De Backer UGent, Guido Lopes dos Santos Santiago UGent, Chris Vervaet UGent, Mario Vaneechoutte UGent, Fabienne De Boeck UGent and Lucas Van Bortel UGent, et al. (2009) EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 73(2). p.280-284
abstract
Non-disintegrating microcrystalline cellulose pellets (MCC) and disintegrating starch-based pellets were evaluated as new vaginal drug delivery forms and compared with a powder formulation. Pellets and powder were packed in a HPMC or hard gelatine capsule and vaginally administered to five series of five healthy volunteers. Distribution and retention of the multi-particulate formulation was monitored by colposcopy and swabbing. Capsule disintegration in the vagina was slow. MCC pellets clustered around the fornix 3 h after administration, and after 24 h only a few pellets were detected in the vaginal cavity. In contrast, starch-based pellets already started to disintegrate 6 h after administration, resulting in a complete coverage of the vaginal mucosa after 24 h in 8 out of 10 volunteers. The powder formulation had a better distribution after 6 h, although after 24 h almost no powder remained in the vagina. These results were confirmed by swabbing to determine the amount of riboflavin sodium phosphate (used as marker) distributed in the different vaginal regions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DRUG-DELIVERY, BACTERIAL VAGINOSIS, DISINTEGRATION TEST, ROUTE, MICROBICIDE, WOMEN, TABLETS
journal title
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Eur. J. Pharm. Biopharm.
volume
73
issue
2
pages
5 pages
publisher
Elsevier Science
place of publication
AMSTERDAM
Web of Science type
Article
Web of Science id
000271153300009
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
3.151 (2009)
JCR rank
70/236 (2009)
JCR quartile
2 (2009)
ISSN
0939-6411
DOI
10.1016/j.ejpb.2009.06.005
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
790704
handle
http://hdl.handle.net/1854/LU-790704
date created
2009-11-27 16:13:00
date last changed
2009-12-10 10:33:28
@article{790704,
  abstract     = {Non-disintegrating microcrystalline cellulose pellets (MCC) and disintegrating starch-based pellets were evaluated as new vaginal drug delivery forms and compared with a powder formulation. Pellets and powder were packed in a HPMC or hard gelatine capsule and vaginally administered to five series of five healthy volunteers. Distribution and retention of the multi-particulate formulation was monitored by colposcopy and swabbing. Capsule disintegration in the vagina was slow. MCC pellets clustered around the fornix 3 h after administration, and after 24 h only a few pellets were detected in the vaginal cavity. In contrast, starch-based pellets already started to disintegrate 6 h after administration, resulting in a complete coverage of the vaginal mucosa after 24 h in 8 out of 10 volunteers. The powder formulation had a better distribution after 6 h, although after 24 h almost no powder remained in the vagina. These results were confirmed by swabbing to determine the amount of riboflavin sodium phosphate (used as marker) distributed in the different vaginal regions.},
  author       = {Poelvoorde, Nele and Verstraelen, Hans and Verhelst, Rita and Saerens, Bart and De Backer, Ellen and Lopes dos Santos Santiago, Guido and Vervaet, Chris and Vaneechoutte, Mario and De Boeck, Fabienne and Van Bortel, Lucas and Temmerman, Marleen and Remon, Jean Paul},
  issn         = {0939-6411},
  journal      = {EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS},
  keyword      = {DRUG-DELIVERY,BACTERIAL VAGINOSIS,DISINTEGRATION TEST,ROUTE,MICROBICIDE,WOMEN,TABLETS},
  language     = {eng},
  number       = {2},
  pages        = {280--284},
  publisher    = {Elsevier Science},
  title        = {In vivo evaluation of the vaginal distribution and retention of a multi-particulate pellet formulation},
  url          = {http://dx.doi.org/10.1016/j.ejpb.2009.06.005},
  volume       = {73},
  year         = {2009},
}

Chicago
Poelvoorde, Nele, Hans Verstraelen, Rita Verhelst, Bart Saerens, Ellen De Backer, Guido Lopes dos Santos Santiago, Chris Vervaet, et al. 2009. “In Vivo Evaluation of the Vaginal Distribution and Retention of a Multi-particulate Pellet Formulation.” European Journal of Pharmaceutics and Biopharmaceutics 73 (2): 280–284.
APA
Poelvoorde, N., Verstraelen, H., Verhelst, R., Saerens, B., De Backer, E., Lopes dos Santos Santiago, G., Vervaet, C., et al. (2009). In vivo evaluation of the vaginal distribution and retention of a multi-particulate pellet formulation. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 73(2), 280–284.
Vancouver
1.
Poelvoorde N, Verstraelen H, Verhelst R, Saerens B, De Backer E, Lopes dos Santos Santiago G, et al. In vivo evaluation of the vaginal distribution and retention of a multi-particulate pellet formulation. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. AMSTERDAM: Elsevier Science; 2009;73(2):280–4.
MLA
Poelvoorde, Nele, Hans Verstraelen, Rita Verhelst, et al. “In Vivo Evaluation of the Vaginal Distribution and Retention of a Multi-particulate Pellet Formulation.” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 73.2 (2009): 280–284. Print.