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Intensity-modulated radiotherapy for recurrent and second primary head and neck cancer in previously irradiated territory

Fréderic Duprez UGent, Indira Madani UGent, KATRIEN BONTE UGent, Tom Boterberg UGent, Luc Vakaet UGent, Cristina Derie, Werner De Gersem UGent and Wilfried De Neve UGent (2009) RADIOTHERAPY AND ONCOLOGY. 93(3). p.563-569
abstract
PURPOSE: To evaluate re-irradiation using IMRT for recurrent and second primary head and neck cancer in previously irradiated territory. MATERIALS AND METHODS: Between 1997 and 2008, 84 patients with recurrent and second primary head and neck cancer were treated with IMRT to a median dose of 69Gy. Median time interval between initial radiotherapy and re-irradiation was 49.5 (5.2-298.3) months. Salvage surgery preceded re-irradiation in 19 patients; 17 patients received concurrent chemotherapy. RESULTS: Median follow-up of living patients was 19.8 (1.9-76.1) months. Five-year locoregional control and overall survival were 40% and 20%, respectively. Five-year disease-specific survival and disease-free survival were 29% and 15%, respectively. Stage T4 (p=0.015), time interval between initial treatment and re-irradiation (p=0.011) and hypopharyngeal cancer (p=0.013) were independent prognostic factors for worse overall survival in multivariate analysis. Twenty-six and 11 patients developed Grade 3 acute and late toxicity, respectively. No Grade 5 acute toxicity was encountered. There were 2 fatal vascular ruptures during follow-up. CONCLUSIONS: High-dose IMRT for recurrent and second primary head and neck cancer in previously irradiated territory leads to approximately 20% long-term survival in a non-selected patient population. Identification of patients who would benefit most of curative IMRT is warranted.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Recurrent head and neck cancer, Second primary head and neck cancer, IMRT, Re-irradiation
journal title
RADIOTHERAPY AND ONCOLOGY
Radiother. Oncol.
volume
93
issue
3
pages
563 - 569
publisher
Elsevier
Web of Science type
Article
Web of Science id
000272762900032
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
4.343 (2009)
JCR rank
8/104 (2009)
JCR quartile
1 (2009)
ISSN
0167-8140
DOI
10.1016/j.radonc.2009.10.012
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
790417
handle
http://hdl.handle.net/1854/LU-790417
date created
2009-11-26 20:12:03
date last changed
2010-01-22 12:28:55
@article{790417,
  abstract     = {PURPOSE: To evaluate re-irradiation using IMRT for recurrent and second primary head and neck cancer in previously irradiated territory. MATERIALS AND METHODS: Between 1997 and 2008, 84 patients with recurrent and second primary head and neck cancer were treated with IMRT to a median dose of 69Gy. Median time interval between initial radiotherapy and re-irradiation was 49.5 (5.2-298.3) months. Salvage surgery preceded re-irradiation in 19 patients; 17 patients received concurrent chemotherapy. RESULTS: Median follow-up of living patients was 19.8 (1.9-76.1) months. Five-year locoregional control and overall survival were 40\% and 20\%, respectively. Five-year disease-specific survival and disease-free survival were 29\% and 15\%, respectively. Stage T4 (p=0.015), time interval between initial treatment and re-irradiation (p=0.011) and hypopharyngeal cancer (p=0.013) were independent prognostic factors for worse overall survival in multivariate analysis. Twenty-six and 11 patients developed Grade 3 acute and late toxicity, respectively. No Grade 5 acute toxicity was encountered. There were 2 fatal vascular ruptures during follow-up. CONCLUSIONS: High-dose IMRT for recurrent and second primary head and neck cancer in previously irradiated territory leads to approximately 20\% long-term survival in a non-selected patient population. Identification of patients who would benefit most of curative IMRT is warranted.},
  author       = {Duprez, Fr{\'e}deric and Madani, Indira and BONTE, KATRIEN and Boterberg, Tom and Vakaet, Luc and Derie, Cristina and De Gersem, Werner and De Neve, Wilfried},
  issn         = {0167-8140},
  journal      = {RADIOTHERAPY AND ONCOLOGY},
  keyword      = {Recurrent head and neck cancer,Second primary head and neck cancer,IMRT,Re-irradiation},
  language     = {eng},
  number       = {3},
  pages        = {563--569},
  publisher    = {Elsevier},
  title        = {Intensity-modulated radiotherapy for recurrent and second primary head and neck cancer in previously irradiated territory},
  url          = {http://dx.doi.org/10.1016/j.radonc.2009.10.012},
  volume       = {93},
  year         = {2009},
}

Chicago
Duprez, Fréderic, Indira Madani, KATRIEN BONTE, Tom Boterberg, Luc Vakaet, Cristina Derie, Werner De Gersem, and Wilfried De Neve. 2009. “Intensity-modulated Radiotherapy for Recurrent and Second Primary Head and Neck Cancer in Previously Irradiated Territory.” Radiotherapy and Oncology 93 (3): 563–569.
APA
Duprez, F., Madani, I., BONTE, K., Boterberg, T., Vakaet, L., Derie, C., De Gersem, W., et al. (2009). Intensity-modulated radiotherapy for recurrent and second primary head and neck cancer in previously irradiated territory. RADIOTHERAPY AND ONCOLOGY, 93(3), 563–569.
Vancouver
1.
Duprez F, Madani I, BONTE K, Boterberg T, Vakaet L, Derie C, et al. Intensity-modulated radiotherapy for recurrent and second primary head and neck cancer in previously irradiated territory. RADIOTHERAPY AND ONCOLOGY. Elsevier; 2009;93(3):563–9.
MLA
Duprez, Fréderic, Indira Madani, KATRIEN BONTE, et al. “Intensity-modulated Radiotherapy for Recurrent and Second Primary Head and Neck Cancer in Previously Irradiated Territory.” RADIOTHERAPY AND ONCOLOGY 93.3 (2009): 563–569. Print.