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Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

Stefaan De Koker (UGent) , Bruno De Geest (UGent) , Satwinder Singh, Riet De Rycke, Thomas Naessens (UGent) , Yvette Van Kooyk, Jo Demeester (UGent) , Stefaan De Smedt (UGent) and Johan Grooten (UGent)
(2009) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 48(45). p.8485-8489
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Organization
Abstract
Degradable polyelectrolyte microcapsules (PMs; see picture) as antigen delivery vehicles are taken up by dendritic cells (DCs) by macropinocytosis. Following uptake, the shell of the microcapsules ruptures, resulting in the invasion of the capsules by the cellular cytoplasm, thus allowing DCs to efficiently process encapsulated antigen.
Keywords
PARTICLES, MICROPARTICLES, MECHANISMS, VACCINES, IN-VIVO, PROTEIN ENCAPSULATION, MULTILAYER CAPSULES, INHIBITION, ACTIVATION, INTERNALIZATION

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MLA
De Koker, Stefaan, et al. “Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 48, no. 45, WILEY-V C H VERLAG GMBH, 2009, pp. 8485–89, doi:10.1002/anie.200903769.
APA
De Koker, S., De Geest, B., Singh, S., De Rycke, R., Naessens, T., Van Kooyk, Y., … Grooten, J. (2009). Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(45), 8485–8489. https://doi.org/10.1002/anie.200903769
Chicago author-date
De Koker, Stefaan, Bruno De Geest, Satwinder Singh, Riet De Rycke, Thomas Naessens, Yvette Van Kooyk, Jo Demeester, Stefaan De Smedt, and Johan Grooten. 2009. “Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48 (45): 8485–89. https://doi.org/10.1002/anie.200903769.
Chicago author-date (all authors)
De Koker, Stefaan, Bruno De Geest, Satwinder Singh, Riet De Rycke, Thomas Naessens, Yvette Van Kooyk, Jo Demeester, Stefaan De Smedt, and Johan Grooten. 2009. “Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48 (45): 8485–8489. doi:10.1002/anie.200903769.
Vancouver
1.
De Koker S, De Geest B, Singh S, De Rycke R, Naessens T, Van Kooyk Y, et al. Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2009;48(45):8485–9.
IEEE
[1]
S. De Koker et al., “Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens,” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 48, no. 45, pp. 8485–8489, 2009.
@article{790094,
  abstract     = {{Degradable polyelectrolyte microcapsules (PMs; see picture) as antigen delivery vehicles are taken up by dendritic cells (DCs) by macropinocytosis. Following uptake, the shell of the microcapsules ruptures, resulting in the invasion of the capsules by the cellular cytoplasm, thus allowing DCs to efficiently process encapsulated antigen.}},
  author       = {{De Koker, Stefaan and De Geest, Bruno and Singh, Satwinder and De Rycke, Riet and Naessens, Thomas and Van Kooyk, Yvette and Demeester, Jo and De Smedt, Stefaan and Grooten, Johan}},
  issn         = {{1433-7851}},
  journal      = {{ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}},
  keywords     = {{PARTICLES,MICROPARTICLES,MECHANISMS,VACCINES,IN-VIVO,PROTEIN ENCAPSULATION,MULTILAYER CAPSULES,INHIBITION,ACTIVATION,INTERNALIZATION}},
  language     = {{eng}},
  number       = {{45}},
  pages        = {{8485--8489}},
  publisher    = {{WILEY-V C H VERLAG GMBH}},
  title        = {{Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens}},
  url          = {{http://dx.doi.org/10.1002/anie.200903769}},
  volume       = {{48}},
  year         = {{2009}},
}
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