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Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair

Jean-Christophe Marine (UGent) and Geert Berx (UGent)
(2009) BREAST CANCER RESEARCH. 11(4). p.AR304-1-AR304-2
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Abstract
How and when a tumor acquires metastatic properties remain largely unknown. Recent work has uncovered an intricate new mechanism through which transforming growth factor-beta (TGFβ) acts in concert with oncogenic Ras to antagonize p63-metastasis protective function. p63 inhibition requires the combined action of Ras-activated mutant p53 and TGFβ-induced Smads. Mechanistically, it involves the formation of a p63-Smads-mutant p53 ternary complex. Remarkably, just two of the key downstream targets of p63 turn out to be sufficient as a prognostic tool for breast cancer metastasis. Moreover, the molecular mechanism of this inhibition points to novel therapeutic possibilities.
Keywords
GAIN, CELLS, MUTATION, PLASTICITY, LI-FRAUMENI-SYNDROME, RAS, TGF-BETA, MICE

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Chicago
Marine, Jean-Christophe, and Geert Berx. 2009. “Transforming Growth Factor-beta and Mutant P53 Conspire to Induce Metastasis by Antagonizing P63: a (ternary) Complex Affair.” Breast Cancer Research 11 (4): AR304–1–AR304–2.
APA
Marine, J.-C., & Berx, G. (2009). Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair. BREAST CANCER RESEARCH, 11(4), AR304–1–AR304–2.
Vancouver
1.
Marine J-C, Berx G. Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair. BREAST CANCER RESEARCH. LONDON: BIOMED CENTRAL LTD; 2009;11(4):AR304–1–AR304–2.
MLA
Marine, Jean-Christophe, and Geert Berx. “Transforming Growth Factor-beta and Mutant P53 Conspire to Induce Metastasis by Antagonizing P63: a (ternary) Complex Affair.” BREAST CANCER RESEARCH 11.4 (2009): AR304–1–AR304–2. Print.
@article{788063,
  abstract     = {How and when a tumor acquires metastatic properties remain largely unknown. Recent work has uncovered an intricate new mechanism through which transforming growth factor-beta (TGF\ensuremath{\beta}) acts in concert with oncogenic Ras to antagonize p63-metastasis protective function. p63 inhibition requires the combined action of Ras-activated mutant p53 and TGF\ensuremath{\beta}-induced Smads. Mechanistically, it involves the formation of a p63-Smads-mutant p53 ternary complex. Remarkably, just two of the key downstream targets of p63 turn out to be sufficient as a prognostic tool for breast cancer metastasis. Moreover, the molecular mechanism of this inhibition points to novel therapeutic possibilities.},
  author       = {Marine, Jean-Christophe and Berx, Geert},
  issn         = {1465-5411},
  journal      = {BREAST CANCER RESEARCH},
  language     = {eng},
  number       = {4},
  pages        = {AR304-1--AR304-2},
  publisher    = {BIOMED CENTRAL LTD},
  title        = {Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair},
  url          = {http://dx.doi.org/10.1186/bcr2337},
  volume       = {11},
  year         = {2009},
}

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