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SitePredicting the cleavage of proteinase substrates

Jelle Verspurten UGent, Kris Gevaert UGent, Wim Declercq UGent and Peter Vandenabeele UGent (2009) TRENDS IN BIOCHEMICAL SCIENCES. 34(7). p.319-323
abstract
Proteinases are enzymes that play important roles in vital cellular and extracellular processes by hydrolytically cleaving peptide bonds in their protein substrates. This cleavage can be non-specific as part of degradation during protein catabolism or highly specific as part of proteolytic cascades and signal transduction events. Several web tools are available for predicting possible cleavage sites in candidate substrates. Here, we compare existing prediction tools with SitePrediction, a novel and user-friendly tool for identifying potential cleavage sites. This prediction is based on known datasets found in the literature, stored in web-accessible repositories or generated by our own experiments. Comparison of the different programs shows that Site- Prediction makes it possible to derive more reliable predictions. In addition, this tool allows the use of a wide range of proteinases.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CASPASE FAMILY, SERVER, GRANZYME-B, SPECIFICITIES, PREFERENCES, PREDICTION, PROTEOMICS, APOPTOSIS, PROTEASES, SEQUENCES
journal title
TRENDS IN BIOCHEMICAL SCIENCES
Trends Biochem.Sci.
volume
34
issue
7
pages
5 pages
publisher
ELSEVIER SCIENCE LONDON
place of publication
LONDON
Web of Science type
Article
Web of Science id
000268644600001
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
11.572 (2009)
JCR rank
12/281 (2009)
JCR quartile
1 (2009)
ISSN
0968-0004
DOI
10.1016/j.tibs.2009.04.001
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
787342
handle
http://hdl.handle.net/1854/LU-787342
date created
2009-11-23 13:37:24
date last changed
2012-06-26 14:31:48
@article{787342,
  abstract     = {Proteinases are enzymes that play important roles in
vital cellular and extracellular processes by hydrolytically
cleaving peptide bonds in their protein substrates.
This cleavage can be non-specific as part of degradation
during protein catabolism or highly specific as part of
proteolytic cascades and signal transduction events.
Several web tools are available for predicting possible
cleavage sites in candidate substrates. Here, we compare
existing prediction tools with SitePrediction, a
novel and user-friendly tool for identifying potential
cleavage sites. This prediction is based on known datasets
found in the literature, stored in web-accessible
repositories or generated by our own experiments.
Comparison of the different programs shows that Site-
Prediction makes it possible to derive more reliable
predictions. In addition, this tool allows the use of
a wide range of proteinases.},
  author       = {Verspurten, Jelle and Gevaert, Kris and Declercq, Wim and Vandenabeele, Peter},
  issn         = {0968-0004},
  journal      = {TRENDS IN BIOCHEMICAL SCIENCES},
  keyword      = {CASPASE FAMILY,SERVER,GRANZYME-B,SPECIFICITIES,PREFERENCES,PREDICTION,PROTEOMICS,APOPTOSIS,PROTEASES,SEQUENCES},
  language     = {eng},
  number       = {7},
  pages        = {319--323},
  publisher    = {ELSEVIER SCIENCE LONDON},
  title        = {SitePredicting the cleavage of proteinase substrates},
  url          = {http://dx.doi.org/10.1016/j.tibs.2009.04.001},
  volume       = {34},
  year         = {2009},
}

Chicago
Verspurten, Jelle, Kris Gevaert, Wim Declercq, and Peter Vandenabeele. 2009. “SitePredicting the Cleavage of Proteinase Substrates.” Trends in Biochemical Sciences 34 (7): 319–323.
APA
Verspurten, J., Gevaert, K., Declercq, W., & Vandenabeele, P. (2009). SitePredicting the cleavage of proteinase substrates. TRENDS IN BIOCHEMICAL SCIENCES, 34(7), 319–323.
Vancouver
1.
Verspurten J, Gevaert K, Declercq W, Vandenabeele P. SitePredicting the cleavage of proteinase substrates. TRENDS IN BIOCHEMICAL SCIENCES. LONDON: ELSEVIER SCIENCE LONDON; 2009;34(7):319–23.
MLA
Verspurten, Jelle, Kris Gevaert, Wim Declercq, et al. “SitePredicting the Cleavage of Proteinase Substrates.” TRENDS IN BIOCHEMICAL SCIENCES 34.7 (2009): 319–323. Print.