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A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure

Petra Willems (UGent) , Kim De Ruyck (UGent) , Rudy Van den Broecke (UGent) , Amin Makar (UGent) , Gianpaolo Perletti, Hubert Thierens (UGent) and Anne Vral (UGent)
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Abstract
Polymorphisms in double strand break repair genes could be involved in genetic breast cancer predisposition as enhanced chromosomal radiosensitivity is a hallmark for breast cancer. Previously, the c.-1310 C > G SNP, located in the Ku70 promoter, showed a significant odds ratio (OR) of 1.85 (P = 0.048) in sporadic, but not familial breast cancer patients, indicating that other factors besides genetic aptitude influence this association. As breast epithelium is exposed to endogenous oxidative stress through oestrogen exposure, the influence of hormone exposure was further examined. A significant OR (1.69, P = 0.017) was found for an enlarged patient population through PCR-RFLP assays in a case-control study in a Belgian population. After dividing the patient population according to oestrogen exposure, high and significant ORs were seen for patients with a longer oestrogen exposure (late age at menopause: OR = 1.96, P = 0.029). These results show that the variant allele of c.-1310 C > G, located in the Ku70 promoter, is a risk allele for breast cancer. Furthermore, the association of the c.-1310 C > G SNP with breast cancer risk was stronger in women with a long oestrogen exposure.

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MLA
Willems, Petra et al. “A Polymorphism in the Promoter Region of Ku70/XRCC6, Associated with Breast Cancer Risk and Oestrogen Exposure.” JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 135.9 (2009): 1159–1168. Print.
APA
Willems, Petra, De Ruyck, K., Van den Broecke, R., Makar, A., Perletti, G., Thierens, H., & Vral, A. (2009). A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 135(9), 1159–1168.
Chicago author-date
Willems, Petra, Kim De Ruyck, Rudy Van den Broecke, Amin Makar, Gianpaolo Perletti, Hubert Thierens, and Anne Vral. 2009. “A Polymorphism in the Promoter Region of Ku70/XRCC6, Associated with Breast Cancer Risk and Oestrogen Exposure.” Journal of Cancer Research and Clinical Oncology 135 (9): 1159–1168.
Chicago author-date (all authors)
Willems, Petra, Kim De Ruyck, Rudy Van den Broecke, Amin Makar, Gianpaolo Perletti, Hubert Thierens, and Anne Vral. 2009. “A Polymorphism in the Promoter Region of Ku70/XRCC6, Associated with Breast Cancer Risk and Oestrogen Exposure.” Journal of Cancer Research and Clinical Oncology 135 (9): 1159–1168.
Vancouver
1.
Willems P, De Ruyck K, Van den Broecke R, Makar A, Perletti G, Thierens H, et al. A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2009;135(9):1159–68.
IEEE
[1]
P. Willems et al., “A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure,” JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol. 135, no. 9, pp. 1159–1168, 2009.
@article{761419,
  abstract     = {{Polymorphisms in double strand break repair genes could be involved in genetic breast cancer predisposition as enhanced chromosomal radiosensitivity is a hallmark for breast cancer. Previously, the c.-1310 C > G SNP, located in the Ku70 promoter, showed a significant odds ratio (OR) of 1.85 (P = 0.048) in sporadic, but not familial breast cancer patients, indicating that other factors besides genetic aptitude influence this association. As breast epithelium is exposed to endogenous oxidative stress through oestrogen exposure, the influence of hormone exposure was further examined.
A significant OR (1.69, P = 0.017) was found for an enlarged patient population through PCR-RFLP assays in a case-control study in a Belgian population. After dividing the patient population according to oestrogen exposure, high and significant ORs were seen for patients with a longer oestrogen exposure (late age at menopause: OR = 1.96, P = 0.029).

These results show that the variant allele of c.-1310 C > G, located in the Ku70 promoter, is a risk allele for breast cancer. Furthermore, the association of the c.-1310 C > G SNP with breast cancer risk was stronger in women with a long oestrogen exposure.}},
  author       = {{Willems, Petra and De Ruyck, Kim and Van den Broecke, Rudy and Makar, Amin and Perletti, Gianpaolo and Thierens, Hubert and Vral, Anne}},
  issn         = {{0171-5216}},
  journal      = {{JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1159--1168}},
  title        = {{A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure}},
  url          = {{http://dx.doi.org/10.1007/s00432-009-0556-x}},
  volume       = {{135}},
  year         = {{2009}},
}

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