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A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure

Petra Willems UGent, Kim De Ruyck UGent, Rudy Van den Broecke UGent, Amin Makar UGent, Gianpaolo Perletti, Hubert Thierens UGent and Anne Vral UGent (2009) JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 135(9). p.1159-1168
abstract
Polymorphisms in double strand break repair genes could be involved in genetic breast cancer predisposition as enhanced chromosomal radiosensitivity is a hallmark for breast cancer. Previously, the c.-1310 C > G SNP, located in the Ku70 promoter, showed a significant odds ratio (OR) of 1.85 (P = 0.048) in sporadic, but not familial breast cancer patients, indicating that other factors besides genetic aptitude influence this association. As breast epithelium is exposed to endogenous oxidative stress through oestrogen exposure, the influence of hormone exposure was further examined. A significant OR (1.69, P = 0.017) was found for an enlarged patient population through PCR-RFLP assays in a case-control study in a Belgian population. After dividing the patient population according to oestrogen exposure, high and significant ORs were seen for patients with a longer oestrogen exposure (late age at menopause: OR = 1.96, P = 0.029). These results show that the variant allele of c.-1310 C > G, located in the Ku70 promoter, is a risk allele for breast cancer. Furthermore, the association of the c.-1310 C > G SNP with breast cancer risk was stronger in women with a long oestrogen exposure.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
J. Cancer Res. Clin. Oncol.
volume
135
issue
9
pages
1159 - 1168
Web of Science type
Article
Web of Science id
000268512800003
JCR category
ONCOLOGY
JCR impact factor
2.261 (2009)
JCR rank
88/163 (2009)
JCR quartile
3 (2009)
ISSN
0171-5216
DOI
10.1007/s00432-009-0556-x
language
English
UGent publication?
yes
classification
A1
id
761419
handle
http://hdl.handle.net/1854/LU-761419
date created
2009-10-07 11:41:56
date last changed
2009-11-06 10:17:29
@article{761419,
  abstract     = {Polymorphisms in double strand break repair genes could be involved in genetic breast cancer predisposition as enhanced chromosomal radiosensitivity is a hallmark for breast cancer. Previously, the c.-1310 C {\textrangle} G SNP, located in the Ku70 promoter, showed a significant odds ratio (OR) of 1.85 (P = 0.048) in sporadic, but not familial breast cancer patients, indicating that other factors besides genetic aptitude influence this association. As breast epithelium is exposed to endogenous oxidative stress through oestrogen exposure, the influence of hormone exposure was further examined.
A significant OR (1.69, P = 0.017) was found for an enlarged patient population through PCR-RFLP assays in a case-control study in a Belgian population. After dividing the patient population according to oestrogen exposure, high and significant ORs were seen for patients with a longer oestrogen exposure (late age at menopause: OR = 1.96, P = 0.029).

These results show that the variant allele of c.-1310 C {\textrangle} G, located in the Ku70 promoter, is a risk allele for breast cancer. Furthermore, the association of the c.-1310 C {\textrangle} G SNP with breast cancer risk was stronger in women with a long oestrogen exposure.},
  author       = {Willems, Petra and De Ruyck, Kim and Van den Broecke, Rudy and Makar, Amin and Perletti, Gianpaolo and Thierens, Hubert and Vral, Anne},
  issn         = {0171-5216},
  journal      = {JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY},
  language     = {eng},
  number       = {9},
  pages        = {1159--1168},
  title        = {A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure},
  url          = {http://dx.doi.org/10.1007/s00432-009-0556-x},
  volume       = {135},
  year         = {2009},
}

Chicago
Willems, Petra, Kim De Ruyck, Rudy Van den Broecke, Amin Makar, Gianpaolo Perletti, Hubert Thierens, and Anne Vral. 2009. “A Polymorphism in the Promoter Region of Ku70/XRCC6, Associated with Breast Cancer Risk and Oestrogen Exposure.” Journal of Cancer Research and Clinical Oncology 135 (9): 1159–1168.
APA
Willems, P., De Ruyck, K., Van den Broecke, R., Makar, A., Perletti, G., Thierens, H., & Vral, A. (2009). A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 135(9), 1159–1168.
Vancouver
1.
Willems P, De Ruyck K, Van den Broecke R, Makar A, Perletti G, Thierens H, et al. A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2009;135(9):1159–68.
MLA
Willems, Petra, Kim De Ruyck, Rudy Van den Broecke, et al. “A Polymorphism in the Promoter Region of Ku70/XRCC6, Associated with Breast Cancer Risk and Oestrogen Exposure.” JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 135.9 (2009): 1159–1168. Print.