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Exergetic life cycle analysis for the selection of chromatographic separation processes in the pharmaceutical industry: preparative HPLC versus preparative SFC

Geert Van der Vorst UGent, Herman Van Langenhove UGent, Frederik De Paep, Wim Aelterman, Jules Dingenen and Jo Dewulf UGent (2009) GREEN CHEMISTRY. 11(7). p.1007-1012
abstract
Today, environmentally responsible chemistry is of huge importance in the wake of sustainable production. In the field of the. ne chemical and pharmaceutical industry, preparative supercritical fluid chromatography (Prep-SFC) and preparative high performance liquid chromatography (Prep-HPLC) are widely used chiral separation techniques. Prep-SFC is often named as a green alternative for Prep-HPLC without having a thorough assessment of the greenness. However, if metrics are used for process selection with respect to green chemistry, they mainly show three shortcomings: (1) a narrow system boundary approach is used; (2) energy requirements are barely taken into account and (3) if energy requirements are considered, there is a differentiation in mass and energy inputs. Taking into account these shortcomings, Prep-HPLC and Prep-SFC are now compared and evaluated for their integral resource consumption. The evaluation is performed on a specific enantiomeric separation using exergetic life cycle analysis within enlarging system boundaries alpha, beta and gamma. Within the a system boundary (process level), Prep-HPLC requires 26.3% more resources quantified in exergy than the Prep-SFC separation due to its inherent higher use of organic solvents. Within the b system boundary (plant level), Prep-HPLC requires 29.1% more resources quantified in exergy than Prep-SFC. However, the Cumulative Exergy Extracted from the Natural Environment (CEENE) to deliver all mass and energy flows to the a and b system boundary via the overall industrial metabolism shows that Prep-SFC requires 34.3% more resources than Prep-HPLC. The poor score of Prep-SFC in the g system boundary is attributed to the high CEENE value related to the production of liquid carbon dioxide and the use of electricity for heating and cooling. It can be concluded that for this case, the most sustainable process as for the integral resource consumption is Prep-HPLC, unlike the general perception that Prep-SFC outperforms Prep-HPLC.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FLUID CHROMATOGRAPHY, GREEN CHEMISTRY, TECHNOLOGY, SUSTAINABILITY, MANAGEMENT, CANDIDATE, DESIGN
journal title
GREEN CHEMISTRY
Green Chem.
volume
11
issue
7
pages
1007 - 1012
Web of Science type
Article
Web of Science id
000267727800018
JCR category
CHEMISTRY, MULTIDISCIPLINARY
JCR impact factor
5.836 (2009)
JCR rank
14/137 (2009)
JCR quartile
1 (2009)
ISSN
1463-9262
DOI
10.1039/b901151j
language
English
UGent publication?
yes
classification
A1
id
761397
handle
http://hdl.handle.net/1854/LU-761397
date created
2009-10-07 10:33:21
date last changed
2009-11-30 15:57:43
@article{761397,
  abstract     = {Today, environmentally responsible chemistry is of huge importance in the wake of sustainable production. In the field of the. ne chemical and pharmaceutical industry, preparative supercritical fluid chromatography (Prep-SFC) and preparative high performance liquid chromatography (Prep-HPLC) are widely used chiral separation techniques. Prep-SFC is often named as a green alternative for Prep-HPLC without having a thorough assessment of the greenness. However, if metrics are used for process selection with respect to green chemistry, they mainly show three shortcomings: (1) a narrow system boundary approach is used; (2) energy requirements are barely taken into account and (3) if energy requirements are considered, there is a differentiation in mass and energy inputs. Taking into account these shortcomings, Prep-HPLC and Prep-SFC are now compared and evaluated for their integral resource consumption. The evaluation is performed on a specific enantiomeric separation using exergetic life cycle analysis within enlarging system boundaries alpha, beta and gamma. Within the a system boundary (process level), Prep-HPLC requires 26.3\% more resources quantified in exergy than the Prep-SFC separation due to its inherent higher use of organic solvents. Within the b system boundary (plant level), Prep-HPLC requires 29.1\% more resources quantified in exergy than Prep-SFC. However, the Cumulative Exergy Extracted from the Natural Environment (CEENE) to deliver all mass and energy flows to the a and b system boundary via the overall industrial metabolism shows that Prep-SFC requires 34.3\% more resources than Prep-HPLC. The poor score of Prep-SFC in the g system boundary is attributed to the high CEENE value related to the production of liquid carbon dioxide and the use of electricity for heating and cooling. It can be concluded that for this case, the most sustainable process as for the integral resource consumption is Prep-HPLC, unlike the general perception that Prep-SFC outperforms Prep-HPLC.},
  author       = {Van der Vorst, Geert and Van Langenhove, Herman and De Paep, Frederik and Aelterman, Wim and Dingenen, Jules and Dewulf, Jo},
  issn         = {1463-9262},
  journal      = {GREEN CHEMISTRY},
  keyword      = {FLUID CHROMATOGRAPHY,GREEN CHEMISTRY,TECHNOLOGY,SUSTAINABILITY,MANAGEMENT,CANDIDATE,DESIGN},
  language     = {eng},
  number       = {7},
  pages        = {1007--1012},
  title        = {Exergetic life cycle analysis for the selection of chromatographic separation processes in the pharmaceutical industry: preparative HPLC versus preparative SFC},
  url          = {http://dx.doi.org/10.1039/b901151j},
  volume       = {11},
  year         = {2009},
}

Chicago
Van der Vorst, Geert, Herman Van Langenhove, Frederik De Paep, Wim Aelterman, Jules Dingenen, and Jo Dewulf. 2009. “Exergetic Life Cycle Analysis for the Selection of Chromatographic Separation Processes in the Pharmaceutical Industry: Preparative HPLC Versus Preparative SFC.” Green Chemistry 11 (7): 1007–1012.
APA
Van der Vorst, G., Van Langenhove, H., De Paep, F., Aelterman, W., Dingenen, J., & Dewulf, J. (2009). Exergetic life cycle analysis for the selection of chromatographic separation processes in the pharmaceutical industry: preparative HPLC versus preparative SFC. GREEN CHEMISTRY, 11(7), 1007–1012.
Vancouver
1.
Van der Vorst G, Van Langenhove H, De Paep F, Aelterman W, Dingenen J, Dewulf J. Exergetic life cycle analysis for the selection of chromatographic separation processes in the pharmaceutical industry: preparative HPLC versus preparative SFC. GREEN CHEMISTRY. 2009;11(7):1007–12.
MLA
Van der Vorst, Geert, Herman Van Langenhove, Frederik De Paep, et al. “Exergetic Life Cycle Analysis for the Selection of Chromatographic Separation Processes in the Pharmaceutical Industry: Preparative HPLC Versus Preparative SFC.” GREEN CHEMISTRY 11.7 (2009): 1007–1012. Print.