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Translational control of eukaryotic gene expression

Katrien Van Der Kelen UGent, Rudi Beyaert UGent, Dirk Inzé UGent and Lieven De Veylder UGent (2009) Critical Reviews in Biochemistry and Molecular Biology. 44(4). p.143-168
abstract
Translational control mechanisms are, besides transcriptional control and mRNA stability, the most deter mining for final protein levels. A large number of accessory factors that assist the ribosome during initiation, elongation, and termination of translation are required for protein synthesis. Cap-dependent translational control occurs mainly during the initiation step, involving eukaryotic initiation factors (eIFs) and accessory proteins. Initiation is affected by various stimuli that influence the phosphorylation status of both eIF4E and eIF2 and through binding of 4E-binding proteins to eIF4E, which finally inhibits cap-dependent translation. Under conditions where cap-dependent translation is hampered, translation of transcripts containing an internal ribosome entry site can still be supported in a cap-independent manner. An interesting example of translational control is the switch between cap-independent and cap-dependent translation during the eukaryotic cell cycle. At the G1-to-S transition, translation occurs predominantly in a cap-dependent manner, while during the G2-to-M transition, cap-dependent translation is inhibited and transcripts are predominantly translated through a cap-independent mechanism.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
cell cycle, posttranscriptional regulation, IRES, Initiation of translation
journal title
Critical Reviews in Biochemistry and Molecular Biology
Crit. Rev. Biochem. Mol. Biol.
volume
44
issue
4
pages
143 - 168
Web of Science type
Review
Web of Science id
000269259500001
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
10.216 (2009)
JCR rank
16/281 (2009)
JCR quartile
1 (2009)
ISSN
1040-9238
DOI
10.1080/10409230902882090
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
749078
handle
http://hdl.handle.net/1854/LU-749078
date created
2009-09-15 12:27:48
date last changed
2012-06-26 14:31:46
@article{749078,
  abstract     = {Translational control mechanisms are, besides transcriptional control and mRNA stability, the most deter mining for final protein levels. A large number of accessory factors that assist the ribosome during initiation, elongation, and termination of translation are required for protein synthesis. Cap-dependent translational control occurs mainly during the initiation step, involving eukaryotic initiation factors (eIFs) and accessory proteins. Initiation is affected by various stimuli that influence the phosphorylation status of both eIF4E and eIF2 and through binding of 4E-binding proteins to eIF4E, which finally inhibits cap-dependent translation. Under conditions where cap-dependent translation is hampered, translation of transcripts containing an internal ribosome entry site can still be supported in a cap-independent manner. An interesting example of translational control is the switch between cap-independent and cap-dependent translation during the eukaryotic cell cycle. At the G1-to-S transition, translation occurs predominantly in a cap-dependent manner, while during the G2-to-M transition, cap-dependent translation is inhibited and transcripts are predominantly translated through a cap-independent mechanism.},
  author       = {Van Der Kelen, Katrien and Beyaert, Rudi and Inz{\'e}, Dirk and De Veylder, Lieven},
  issn         = {1040-9238},
  journal      = {Critical Reviews in Biochemistry and Molecular Biology},
  keyword      = {cell cycle,posttranscriptional regulation,IRES,Initiation of translation},
  language     = {eng},
  number       = {4},
  pages        = {143--168},
  title        = {Translational control of eukaryotic gene expression},
  url          = {http://dx.doi.org/10.1080/10409230902882090},
  volume       = {44},
  year         = {2009},
}

Chicago
Van Der Kelen, Katrien, Rudi Beyaert, Dirk Inzé, and Lieven De Veylder. 2009. “Translational Control of Eukaryotic Gene Expression.” Critical Reviews in Biochemistry and Molecular Biology 44 (4): 143–168.
APA
Van Der Kelen, K., Beyaert, R., Inzé, D., & De Veylder, L. (2009). Translational control of eukaryotic gene expression. Critical Reviews in Biochemistry and Molecular Biology, 44(4), 143–168.
Vancouver
1.
Van Der Kelen K, Beyaert R, Inzé D, De Veylder L. Translational control of eukaryotic gene expression. Critical Reviews in Biochemistry and Molecular Biology. 2009;44(4):143–68.
MLA
Van Der Kelen, Katrien, Rudi Beyaert, Dirk Inzé, et al. “Translational Control of Eukaryotic Gene Expression.” Critical Reviews in Biochemistry and Molecular Biology 44.4 (2009): 143–168. Print.