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Translational control of eukaryotic gene expression

Katrien Van Der Kelen (UGent) , Rudi Beyaert (UGent) , Dirk Inzé (UGent) and Lieven De Veylder (UGent)
Author
Organization
Abstract
Translational control mechanisms are, besides transcriptional control and mRNA stability, the most deter mining for final protein levels. A large number of accessory factors that assist the ribosome during initiation, elongation, and termination of translation are required for protein synthesis. Cap-dependent translational control occurs mainly during the initiation step, involving eukaryotic initiation factors (eIFs) and accessory proteins. Initiation is affected by various stimuli that influence the phosphorylation status of both eIF4E and eIF2 and through binding of 4E-binding proteins to eIF4E, which finally inhibits cap-dependent translation. Under conditions where cap-dependent translation is hampered, translation of transcripts containing an internal ribosome entry site can still be supported in a cap-independent manner. An interesting example of translational control is the switch between cap-independent and cap-dependent translation during the eukaryotic cell cycle. At the G1-to-S transition, translation occurs predominantly in a cap-dependent manner, while during the G2-to-M transition, cap-dependent translation is inhibited and transcripts are predominantly translated through a cap-independent mechanism.
Keywords
cell cycle, posttranscriptional regulation, IRES, Initiation of translation

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Citation

Please use this url to cite or link to this publication:

MLA
Van Der Kelen, Katrien et al. “Translational Control of Eukaryotic Gene Expression.” Critical Reviews in Biochemistry and Molecular Biology 44.4 (2009): 143–168. Print.
APA
Van Der Kelen, K., Beyaert, R., Inzé, D., & De Veylder, L. (2009). Translational control of eukaryotic gene expression. Critical Reviews in Biochemistry and Molecular Biology, 44(4), 143–168.
Chicago author-date
Van Der Kelen, Katrien, Rudi Beyaert, Dirk Inzé, and Lieven De Veylder. 2009. “Translational Control of Eukaryotic Gene Expression.” Critical Reviews in Biochemistry and Molecular Biology 44 (4): 143–168.
Chicago author-date (all authors)
Van Der Kelen, Katrien, Rudi Beyaert, Dirk Inzé, and Lieven De Veylder. 2009. “Translational Control of Eukaryotic Gene Expression.” Critical Reviews in Biochemistry and Molecular Biology 44 (4): 143–168.
Vancouver
1.
Van Der Kelen K, Beyaert R, Inzé D, De Veylder L. Translational control of eukaryotic gene expression. Critical Reviews in Biochemistry and Molecular Biology. 2009;44(4):143–68.
IEEE
[1]
K. Van Der Kelen, R. Beyaert, D. Inzé, and L. De Veylder, “Translational control of eukaryotic gene expression,” Critical Reviews in Biochemistry and Molecular Biology, vol. 44, no. 4, pp. 143–168, 2009.
@article{749078,
  abstract     = {Translational control mechanisms are, besides transcriptional control and mRNA stability, the most deter mining for final protein levels. A large number of accessory factors that assist the ribosome during initiation, elongation, and termination of translation are required for protein synthesis. Cap-dependent translational control occurs mainly during the initiation step, involving eukaryotic initiation factors (eIFs) and accessory proteins. Initiation is affected by various stimuli that influence the phosphorylation status of both eIF4E and eIF2 and through binding of 4E-binding proteins to eIF4E, which finally inhibits cap-dependent translation. Under conditions where cap-dependent translation is hampered, translation of transcripts containing an internal ribosome entry site can still be supported in a cap-independent manner. An interesting example of translational control is the switch between cap-independent and cap-dependent translation during the eukaryotic cell cycle. At the G1-to-S transition, translation occurs predominantly in a cap-dependent manner, while during the G2-to-M transition, cap-dependent translation is inhibited and transcripts are predominantly translated through a cap-independent mechanism.},
  author       = {Van Der Kelen, Katrien and Beyaert, Rudi and Inzé, Dirk and De Veylder, Lieven},
  issn         = {1040-9238},
  journal      = {Critical Reviews in Biochemistry and Molecular Biology},
  keywords     = {cell cycle,posttranscriptional regulation,IRES,Initiation of translation},
  language     = {eng},
  number       = {4},
  pages        = {143--168},
  title        = {Translational control of eukaryotic gene expression},
  url          = {http://dx.doi.org/10.1080/10409230902882090},
  volume       = {44},
  year         = {2009},
}

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