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CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset

Véronique Boudolf UGent, Tim Lammens UGent, Joanna Boruc UGent, Jelle Van Leene UGent, Hilde Van Den Daele UGent, Sara Maes UGent, Gert Van Isterdael UGent, Eugenia Russinova UGent, Eva Kondorosi and Erwin Witters, et al. (2009) Plant Physiology. 150(3). p.1482-1493
abstract
The mitosis-to-endocycle transition requires the controlled inactivation of M phase-associated cyclin-dependent kinase (CDK) activity. Previously, the B-type CDKB1;1 was identified as an important negative regulator of endocycle onset. Here, we demonstrate that CDKB1;1 copurifies and associates with the A2-type cyclin CYCA2;3. Coexpression of CYCA2;3 with CDKB1;1 triggered ectopic cell divisions and inhibited endoreduplication. Moreover, the enhanced endoreduplication phenotype observed after overexpression of a dominant-negative allele of CDKB1;1 could be partially complemented by CYCA2;3 co-overexpression, illustrating that both subunits unite in vivo to form a functional complex. CYCA2;3 protein stability was found to be controlled by CCS52A1, an activator of the anaphase-promoting complex. We conclude that CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CYCLIN-DEPENDENT-KINASE, ANAPHASE-PROMOTING COMPLEX, CELL-CYCLE, ARABIDOPSIS-THALIANA, TRANSCRIPTION FACTOR, S-PHASE, FISSION YEAST, PLANT DEVELOPMENT, ENDOREDUPLICATION, DESTRUCTION BOX
journal title
Plant Physiology
Plant Physiol.
volume
150
issue
3
pages
1482 - 1493
Web of Science type
Article
Web of Science id
000268696800031
JCR category
PLANT SCIENCES
JCR impact factor
6.235 (2009)
JCR rank
7/172 (2009)
JCR quartile
1 (2009)
ISSN
0032-0889
DOI
10.1104/pp.109.140269
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
748929
handle
http://hdl.handle.net/1854/LU-748929
date created
2009-09-15 11:12:01
date last changed
2009-10-02 09:00:16
@article{748929,
  abstract     = {The mitosis-to-endocycle transition requires the controlled inactivation of M phase-associated cyclin-dependent kinase (CDK) activity. Previously, the B-type CDKB1;1 was identified as an important negative regulator of endocycle onset. Here, we demonstrate that CDKB1;1 copurifies and associates with the A2-type cyclin CYCA2;3. Coexpression of CYCA2;3 with CDKB1;1 triggered ectopic cell divisions and inhibited endoreduplication. Moreover, the enhanced endoreduplication phenotype observed after overexpression of a dominant-negative allele of CDKB1;1 could be partially complemented by CYCA2;3 co-overexpression, illustrating that both subunits unite in vivo to form a functional complex. CYCA2;3 protein stability was found to be controlled by CCS52A1, an activator of the anaphase-promoting complex. We conclude that CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3.},
  author       = {Boudolf, V{\'e}ronique and Lammens, Tim and Boruc, Joanna and Van Leene, Jelle and Van Den Daele, Hilde and Maes, Sara and Van Isterdael, Gert and Russinova, Eugenia and Kondorosi, Eva and Witters, Erwin and De Jaeger, Geert and Inz{\'e}, Dirk and De Veylder, Lieven},
  issn         = {0032-0889},
  journal      = {Plant Physiology},
  keyword      = {CYCLIN-DEPENDENT-KINASE,ANAPHASE-PROMOTING COMPLEX,CELL-CYCLE,ARABIDOPSIS-THALIANA,TRANSCRIPTION FACTOR,S-PHASE,FISSION YEAST,PLANT DEVELOPMENT,ENDOREDUPLICATION,DESTRUCTION BOX},
  language     = {eng},
  number       = {3},
  pages        = {1482--1493},
  title        = {CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset},
  url          = {http://dx.doi.org/10.1104/pp.109.140269},
  volume       = {150},
  year         = {2009},
}

Chicago
Boudolf, Véronique, Tim Lammens, Joanna Boruc, Jelle Van Leene, Hilde Van Den Daele, Sara Maes, Gert Van Isterdael, et al. 2009. “CDKB1;1 Forms a Functional Complex with CYCA2;3 to Suppress Endocycle Onset.” Plant Physiology 150 (3): 1482–1493.
APA
Boudolf, V., Lammens, T., Boruc, J., Van Leene, J., Van Den Daele, H., Maes, S., Van Isterdael, G., et al. (2009). CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Plant Physiology, 150(3), 1482–1493.
Vancouver
1.
Boudolf V, Lammens T, Boruc J, Van Leene J, Van Den Daele H, Maes S, et al. CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Plant Physiology. 2009;150(3):1482–93.
MLA
Boudolf, Véronique, Tim Lammens, Joanna Boruc, et al. “CDKB1;1 Forms a Functional Complex with CYCA2;3 to Suppress Endocycle Onset.” Plant Physiology 150.3 (2009): 1482–1493. Print.