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Gibberellin signaling controls cell proliferation rate in Arabidopsis

Patrick Achard, Andi Gusti, Solzic Cheminant, Malek Alioua, Stijn Dhondt UGent, Frederik Coppens UGent, Gerrit Beemster UGent and Pascal Genschik (2009) Current Biology. 19(14). p.1188-1193
abstract
Plant growth involves the integration of many environmental and endogenous signals that together with the intrinsic genetic program determine plant size. At the cellular level, growth rate is regulated by the combined activity of two processes: cell proliferation and expansion. Gibberellins (GA) are plant-specific hormones that play a central role in the regulation of growth and development with respect to environmental variability [1-3]. It is well established that GA promote growth through cell expansion by stimulating the destruction of growth-repressing DELLA proteins (DELLAs) [1, 4-6]; however, their effects on cell proliferation remain unknown. Kinematic analysis of leaf and root meristem growth revealed a novel function of DELLAs in restraining cell production. Moreover, by visualizing the cell cycle marker cyclinB1::beta-glucuronidase in GA-signaling mutants, we show that GA modulate cell cycle activity in the root meristem via a DELLA-dependent mechanism. Accordingly, expressing gai (a nondegradable DELLA protein [4]) solely in root meristem reduced substantially the number of dividing cells. We also show that DELLAs restrain cell production by enhancing the levels of the cell cycle inhibitors Kip-related protein 2(KRP2) and SIAMESE (SIM). Therefore, DELLAs exert a general plant growth inhibitory activity by reducing both cell proliferation and expansion rates, enabling phenotypic plasticity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GENE ENCODES, DELLA PROTEIN, CYCLE, GROWTH, RECEPTOR, ENDOREDUPLICATION, DEPENDENT KINASE INHIBITORS, DIFFERENTIATION, E3 UBIQUITIN LIGASE, ROOT-MERISTEM
journal title
Current Biology
Curr. Biol.
volume
19
issue
14
pages
1188 - 1193
Web of Science type
Article
Web of Science id
000268530200025
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
10.992 (2009)
JCR rank
15/281 (2009)
JCR quartile
1 (2009)
ISSN
0960-9822
DOI
10.1016/j.cub.2009.05.059
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
748919
handle
http://hdl.handle.net/1854/LU-748919
date created
2009-09-15 11:02:25
date last changed
2009-10-02 08:55:56
@article{748919,
  abstract     = {Plant growth involves the integration of many environmental and endogenous signals that together with the intrinsic genetic program determine plant size. At the cellular level, growth rate is regulated by the combined activity of two processes: cell proliferation and expansion. Gibberellins (GA) are plant-specific hormones that play a central role in the regulation of growth and development with respect to environmental variability [1-3]. It is well established that GA promote growth through cell expansion by stimulating the destruction of growth-repressing DELLA proteins (DELLAs) [1, 4-6]; however, their effects on cell proliferation remain unknown. Kinematic analysis of leaf and root meristem growth revealed a novel function of DELLAs in restraining cell production. Moreover, by visualizing the cell cycle marker cyclinB1::beta-glucuronidase in GA-signaling mutants, we show that GA modulate cell cycle activity in the root meristem via a DELLA-dependent mechanism. Accordingly, expressing gai (a nondegradable DELLA protein [4]) solely in root meristem reduced substantially the number of dividing cells. We also show that DELLAs restrain cell production by enhancing the levels of the cell cycle inhibitors Kip-related protein 2(KRP2) and SIAMESE (SIM). Therefore, DELLAs exert a general plant growth inhibitory activity by reducing both cell proliferation and expansion rates, enabling phenotypic plasticity.},
  author       = {Achard, Patrick and Gusti, Andi and Cheminant, Solzic and Alioua, Malek and Dhondt, Stijn and Coppens, Frederik and Beemster, Gerrit and Genschik, Pascal},
  issn         = {0960-9822},
  journal      = {Current Biology},
  keyword      = {GENE ENCODES,DELLA PROTEIN,CYCLE,GROWTH,RECEPTOR,ENDOREDUPLICATION,DEPENDENT KINASE INHIBITORS,DIFFERENTIATION,E3 UBIQUITIN LIGASE,ROOT-MERISTEM},
  language     = {eng},
  number       = {14},
  pages        = {1188--1193},
  title        = {Gibberellin signaling controls cell proliferation rate in Arabidopsis},
  url          = {http://dx.doi.org/10.1016/j.cub.2009.05.059},
  volume       = {19},
  year         = {2009},
}

Chicago
Achard, Patrick, Andi Gusti, Solzic Cheminant, Malek Alioua, Stijn Dhondt, Frederik Coppens, Gerrit Beemster, and Pascal Genschik. 2009. “Gibberellin Signaling Controls Cell Proliferation Rate in Arabidopsis.” Current Biology 19 (14): 1188–1193.
APA
Achard, P., Gusti, A., Cheminant, S., Alioua, M., Dhondt, S., Coppens, F., Beemster, G., et al. (2009). Gibberellin signaling controls cell proliferation rate in Arabidopsis. Current Biology, 19(14), 1188–1193.
Vancouver
1.
Achard P, Gusti A, Cheminant S, Alioua M, Dhondt S, Coppens F, et al. Gibberellin signaling controls cell proliferation rate in Arabidopsis. Current Biology. 2009;19(14):1188–93.
MLA
Achard, Patrick, Andi Gusti, Solzic Cheminant, et al. “Gibberellin Signaling Controls Cell Proliferation Rate in Arabidopsis.” Current Biology 19.14 (2009): 1188–1193. Print.