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The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer.

Reinhart Speeckaert, Marijn Speeckaert UGent, Elizaveta Padalko UGent, LUTGARDE CLAEYS UGent and Joris Delanghe UGent (2009) CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 47(7). p.826-828
abstract
Background: Epstein-Barr virus (EBV) is a human herpes virus that persists for life and is associated with several neoplasms. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects. The present study investigated the influence of the genetic polymorphism of Hp on EBV serology. Methods: Patients without immunoglobulin G (IgG) titers of EBV were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 208 individuals against 918 healthy subjects with unknown EBV status. Results: The Hp 1-1 phenotype was associated with a lower EBV antibody titer (p=0.0005). Conclusions: Our study confirms the involvement of the Hp phenotype in infection with EBV. Phenotypes with a higher Hp concentration (Hp 1-1 and Hp 2-1) are less prone to positive EBV serology. Clin Chem Lab Med 2009; 47: 826-8.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
genetic polymorphism, Epstein-Barr virus (EBV), haptoglobin (Hp), serology, KeyWords Plus: HUMAN LYMPHOCYTES-B, RECEPTOR CR-2, IN-VIVO, BINDING, INFECTION, SURVIVAL, CD22, CELLS
journal title
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Clin. Chem. Lab. Med.
volume
47
issue
7
pages
826 - 828
Web of Science type
Article
Web of Science id
000267978900008
JCR category
MEDICAL LABORATORY TECHNOLOGY
JCR impact factor
1.886 (2009)
JCR rank
10/28 (2009)
JCR quartile
2 (2009)
ISSN
1434-6621
DOI
10.1515/CCLM.2009.193
language
English
UGent publication?
yes
classification
A1
id
748857
handle
http://hdl.handle.net/1854/LU-748857
date created
2009-09-15 09:25:50
date last changed
2016-12-19 15:45:44
@article{748857,
  abstract     = {Background: Epstein-Barr virus (EBV) is a human herpes virus that persists for life and is associated with several neoplasms. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects. The present study investigated the influence of the genetic polymorphism of Hp on EBV serology.

Methods: Patients without immunoglobulin G (IgG) titers of EBV were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 208 individuals against 918 healthy subjects with unknown EBV status.

Results: The Hp 1-1 phenotype was associated with a lower EBV antibody titer (p=0.0005).

Conclusions: Our study confirms the involvement of the Hp phenotype in infection with EBV. Phenotypes with a higher Hp concentration (Hp 1-1 and Hp 2-1) are less prone to positive EBV serology. Clin Chem Lab Med 2009; 47: 826-8.},
  author       = {Speeckaert, Reinhart and Speeckaert, Marijn and Padalko, Elizaveta and CLAEYS, LUTGARDE and Delanghe, Joris},
  issn         = {1434-6621},
  journal      = {CLINICAL CHEMISTRY AND LABORATORY MEDICINE},
  keyword      = {genetic polymorphism,Epstein-Barr virus (EBV),haptoglobin (Hp),serology,KeyWords Plus: HUMAN LYMPHOCYTES-B,RECEPTOR CR-2,IN-VIVO,BINDING,INFECTION,SURVIVAL,CD22,CELLS},
  language     = {eng},
  number       = {7},
  pages        = {826--828},
  title        = {The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer.},
  url          = {http://dx.doi.org/10.1515/CCLM.2009.193},
  volume       = {47},
  year         = {2009},
}

Chicago
Speeckaert, Reinhart, Marijn Speeckaert, Elizaveta Padalko, LUTGARDE CLAEYS, and Joris Delanghe. 2009. “The Haptoglobin Phenotype Is Associated with the Epstein-Barr Virus Antibody Titer.” Clinical Chemistry and Laboratory Medicine 47 (7): 826–828.
APA
Speeckaert, R., Speeckaert, M., Padalko, E., CLAEYS, L., & Delanghe, J. (2009). The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 47(7), 826–828.
Vancouver
1.
Speeckaert R, Speeckaert M, Padalko E, CLAEYS L, Delanghe J. The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2009;47(7):826–8.
MLA
Speeckaert, Reinhart, Marijn Speeckaert, Elizaveta Padalko, et al. “The Haptoglobin Phenotype Is Associated with the Epstein-Barr Virus Antibody Titer.” CLINICAL CHEMISTRY AND LABORATORY MEDICINE 47.7 (2009): 826–828. Print.