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The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer.

Reinhart Speeckaert (UGent) , Marijn Speeckaert (UGent) , Elizaveta Padalko (UGent) , LUTGARDE CLAEYS (UGent) and Joris Delanghe (UGent)
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Abstract
Background: Epstein-Barr virus (EBV) is a human herpes virus that persists for life and is associated with several neoplasms. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects. The present study investigated the influence of the genetic polymorphism of Hp on EBV serology. Methods: Patients without immunoglobulin G (IgG) titers of EBV were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 208 individuals against 918 healthy subjects with unknown EBV status. Results: The Hp 1-1 phenotype was associated with a lower EBV antibody titer (p=0.0005). Conclusions: Our study confirms the involvement of the Hp phenotype in infection with EBV. Phenotypes with a higher Hp concentration (Hp 1-1 and Hp 2-1) are less prone to positive EBV serology. Clin Chem Lab Med 2009; 47: 826-8.
Keywords
genetic polymorphism, Epstein-Barr virus (EBV), haptoglobin (Hp), serology, KeyWords Plus: HUMAN LYMPHOCYTES-B, RECEPTOR CR-2, IN-VIVO, BINDING, INFECTION, SURVIVAL, CD22, CELLS

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Chicago
Speeckaert, Reinhart, Marijn Speeckaert, Elizaveta Padalko, LUTGARDE CLAEYS, and Joris Delanghe. 2009. “The Haptoglobin Phenotype Is Associated with the Epstein-Barr Virus Antibody Titer.” Clinical Chemistry and Laboratory Medicine 47 (7): 826–828.
APA
Speeckaert, R., Speeckaert, M., Padalko, E., CLAEYS, L., & Delanghe, J. (2009). The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 47(7), 826–828.
Vancouver
1.
Speeckaert R, Speeckaert M, Padalko E, CLAEYS L, Delanghe J. The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2009;47(7):826–8.
MLA
Speeckaert, Reinhart, Marijn Speeckaert, Elizaveta Padalko, et al. “The Haptoglobin Phenotype Is Associated with the Epstein-Barr Virus Antibody Titer.” CLINICAL CHEMISTRY AND LABORATORY MEDICINE 47.7 (2009): 826–828. Print.
@article{748857,
  abstract     = {Background: Epstein-Barr virus (EBV) is a human herpes virus that persists for life and is associated with several neoplasms. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects. The present study investigated the influence of the genetic polymorphism of Hp on EBV serology.

Methods: Patients without immunoglobulin G (IgG) titers of EBV were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 208 individuals against 918 healthy subjects with unknown EBV status.

Results: The Hp 1-1 phenotype was associated with a lower EBV antibody titer (p=0.0005).

Conclusions: Our study confirms the involvement of the Hp phenotype in infection with EBV. Phenotypes with a higher Hp concentration (Hp 1-1 and Hp 2-1) are less prone to positive EBV serology. Clin Chem Lab Med 2009; 47: 826-8.},
  author       = {Speeckaert, Reinhart and Speeckaert, Marijn and Padalko, Elizaveta and CLAEYS, LUTGARDE and Delanghe, Joris},
  issn         = {1434-6621},
  journal      = {CLINICAL CHEMISTRY AND LABORATORY MEDICINE},
  keyword      = {genetic polymorphism,Epstein-Barr virus (EBV),haptoglobin (Hp),serology,KeyWords Plus: HUMAN LYMPHOCYTES-B,RECEPTOR CR-2,IN-VIVO,BINDING,INFECTION,SURVIVAL,CD22,CELLS},
  language     = {eng},
  number       = {7},
  pages        = {826--828},
  title        = {The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer.},
  url          = {http://dx.doi.org/10.1515/CCLM.2009.193},
  volume       = {47},
  year         = {2009},
}

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