Advanced search
Add to list

Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy

(2008) HEART RHYTHM. 5(9). p.1257-1264
Author
Organization
Abstract
BACKGROUND Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony. OBJECTIVE This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT). METHODS A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony was defined as the standard deviation of the time to reach the minimum systolic volume for 16 LV segments, expressed in percentage of cardiac cycle (systolic dyssynchrony index, SDI). Patients were divided into responders or nonresponders, based on a reduction >= 15% in LV end-systolic volume after CRT. RESULTS Six patients (10%) were excluded from further analysis because of suboptimal images. Of the remaining 51 patients, 34 (67%) were classified as responders. Baseline characteristics were similar between responders and nonresponders, except for the SDI, which was Larger in responders (9.7% +/- 3.6% versus 5.1% +/- 1.8%, P <.0001). ROC curve analysis revealed that a cutoff value for SDI of 6.4% yielded a sensitivity of 88% with a specificity of 85% to predict response to CRT. In responders, RT3DE also showed beneficial effects of CRT on LA: (1) significant LA reverse remodeling; (2) significant improvement in LA total emptying fraction and in LA conduit and reservoir function. CONCLUSION RT3DE allows assessment of changes in LV and LA volumes and function after CRT, and it is highly predictive for response to CRT.
Keywords
real-time three-dimensional echocardiography, cardiac resynchronization therapy, IMAGES, STRAIN, RESERVOIR, DETERMINANTS, DYSSYNCHRONY, RESYNCHRONISATION, heart failure, left ventricular dyssynchrony, left ventricular remodeling, left atrium, VOLUME, IMPROVEMENT, HEART-FAILURE, QUANTIFICATION

Citation

Please use this url to cite or link to this publication:

MLA
Marsan, Nina Ajmone, et al. “Real-Time Three-Dimensional Echocardiography as a Novel Approach to Assess Left Ventricular and Left Atrium Reverse Remodeling and to Predict Response to Cardiac Resynchronization Therapy.” HEART RHYTHM, vol. 5, no. 9, 2008, pp. 1257–64, doi:10.1016/j.hrthm.2008.05.021.
APA
Marsan, N. A., Bleeker, G. B., Ypenburg, C., Van Bommel, R. J., Ghio, S., van de Veire, N., … Bax, J. J. (2008). Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy. HEART RHYTHM, 5(9), 1257–1264. https://doi.org/10.1016/j.hrthm.2008.05.021
Chicago author-date
Marsan, Nina Ajmone, Gabe B. Bleeker, Claudia Ypenburg, Rutger J. Van Bommel, Stefano Ghio, Nico van de Veire, Victoria Delgado, et al. 2008. “Real-Time Three-Dimensional Echocardiography as a Novel Approach to Assess Left Ventricular and Left Atrium Reverse Remodeling and to Predict Response to Cardiac Resynchronization Therapy.” HEART RHYTHM 5 (9): 1257–64. https://doi.org/10.1016/j.hrthm.2008.05.021.
Chicago author-date (all authors)
Marsan, Nina Ajmone, Gabe B. Bleeker, Claudia Ypenburg, Rutger J. Van Bommel, Stefano Ghio, Nico van de Veire, Victoria Delgado, Eduard R. Holman, Ernst E. van der Wall, Martin J. Schalij, and Jeroen J. Bax. 2008. “Real-Time Three-Dimensional Echocardiography as a Novel Approach to Assess Left Ventricular and Left Atrium Reverse Remodeling and to Predict Response to Cardiac Resynchronization Therapy.” HEART RHYTHM 5 (9): 1257–1264. doi:10.1016/j.hrthm.2008.05.021.
Vancouver
1.
Marsan NA, Bleeker GB, Ypenburg C, Van Bommel RJ, Ghio S, van de Veire N, et al. Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy. HEART RHYTHM. 2008;5(9):1257–64.
IEEE
[1]
N. A. Marsan et al., “Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy,” HEART RHYTHM, vol. 5, no. 9, pp. 1257–1264, 2008.
@article{746426,
  abstract     = {{BACKGROUND Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony.

OBJECTIVE This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT).

METHODS A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony was defined as the standard deviation of the time to reach the minimum systolic volume for 16 LV segments, expressed in percentage of cardiac cycle (systolic dyssynchrony index, SDI). Patients were divided into responders or nonresponders, based on a reduction >= 15% in LV end-systolic volume after CRT.

RESULTS Six patients (10%) were excluded from further analysis because of suboptimal images. Of the remaining 51 patients, 34 (67%) were classified as responders. Baseline characteristics were similar between responders and nonresponders, except for the SDI, which was Larger in responders (9.7% +/- 3.6% versus 5.1% +/- 1.8%, P <.0001). ROC curve analysis revealed that a cutoff value for SDI of 6.4% yielded a sensitivity of 88% with a specificity of 85% to predict response to CRT. In responders, RT3DE also showed beneficial effects of CRT on LA: (1) significant LA reverse remodeling; (2) significant improvement in LA total emptying fraction and in LA conduit and reservoir function.

CONCLUSION RT3DE allows assessment of changes in LV and LA volumes and function after CRT, and it is highly predictive for response to CRT.}},
  author       = {{Marsan, Nina Ajmone and Bleeker, Gabe B. and Ypenburg, Claudia and Van Bommel, Rutger J. and Ghio, Stefano and van de Veire, Nico and Delgado, Victoria and Holman, Eduard R. and van der Wall, Ernst E. and Schalij, Martin J. and Bax, Jeroen J.}},
  issn         = {{1547-5271}},
  journal      = {{HEART RHYTHM}},
  keywords     = {{real-time three-dimensional echocardiography,cardiac resynchronization therapy,IMAGES,STRAIN,RESERVOIR,DETERMINANTS,DYSSYNCHRONY,RESYNCHRONISATION,heart failure,left ventricular dyssynchrony,left ventricular remodeling,left atrium,VOLUME,IMPROVEMENT,HEART-FAILURE,QUANTIFICATION}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1257--1264}},
  title        = {{Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy}},
  url          = {{http://doi.org/10.1016/j.hrthm.2008.05.021}},
  volume       = {{5}},
  year         = {{2008}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: