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Results of the predictors of response to CRT (PROSPECT) trial

(2008) CIRCULATION. 117(20). p.2608-2616
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Abstract
Background-Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters to predict CRT response. Methods and Results-Fifty-three centers in Europe, Hong Kong, and the United States enrolled 498 patients with standard CRT indications (New York Heart Association class III or IV heart failure, left ventricular ejection fraction <= 35%, QRS >= 130 ms, stable medical regimen). Twelve echocardiographic parameters of dyssynchrony, based on both conventional and tissue Doppler-based methods, were evaluated after site training in acquisition methods and blinded core laboratory analysis. Indicators of positive CRT response were improved clinical composite score and >= 15% reduction in left ventricular end-systolic volume at 6 months. Clinical composite score was improved in 69% of 426 patients, whereas left ventricular end-systolic volume decreased >= 15% in 56% of 286 patients with paired data. The ability of the 12 echocardiographic parameters to predict clinical composite score response varied widely, with sensitivity ranging from 6% to 74% and specificity ranging from 35% to 91%; for predicting left ventricular end-systolic volume response, sensitivity ranged from 9% to 77% and specificity from 31% to 93%. For all the parameters, the area under the receiver-operating characteristics curve for positive clinical or volume response to CRT was <= 0.62. There was large variability in the analysis of the dyssynchrony parameters. Conclusion-Given the modest sensitivity and specificity in this multicenter setting despite training and central analysis, no single echocardiographic measure of dyssynchrony may be recommended to improve patient selection for CRT beyond current guidelines. Efforts aimed at reducing variability arising from technical and interpretative factors may improve the predictive power of these echocardiographic parameters in a broad clinical setting.
Keywords
dyssynchrony, echocardiography, UPDATE, DIAGNOSIS, GUIDELINE, CARDIOMYOPATHY, STRAIN, Doppler, heart failure, pacemakers, TISSUE, LEFT-VENTRICULAR DYSSYNCHRONY, CARDIAC-RESYNCHRONIZATION THERAPY, CHRONIC HEART-FAILURE

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MLA
Chung, Eugene S. et al. “Results of the Predictors of Response to CRT (PROSPECT) Trial.” CIRCULATION 117.20 (2008): 2608–2616. Print.
APA
Chung, E. S., Leon, A. R., Tavazzi, L., Sun, J.-P., Nihoyannopoulos, P., Merlino, J., Abraham, W. T., et al. (2008). Results of the predictors of response to CRT (PROSPECT) trial. CIRCULATION, 117(20), 2608–2616.
Chicago author-date
Chung, Eugene S., Angel R. Leon, Luigi Tavazzi, Jing-Ping Sun, Petros Nihoyannopoulos, John Merlino, William T. Abraham, et al. 2008. “Results of the Predictors of Response to CRT (PROSPECT) Trial.” Circulation 117 (20): 2608–2616.
Chicago author-date (all authors)
Chung, Eugene S., Angel R. Leon, Luigi Tavazzi, Jing-Ping Sun, Petros Nihoyannopoulos, John Merlino, William T. Abraham, Stefano Ghio, Christophe Leclercq, Jeroen J. Bax, Cheuk-Man Yu, John Gorcsan, Martin St John Sutton, Johan De Sutter, and Jaime Murillo. 2008. “Results of the Predictors of Response to CRT (PROSPECT) Trial.” Circulation 117 (20): 2608–2616.
Vancouver
1.
Chung ES, Leon AR, Tavazzi L, Sun J-P, Nihoyannopoulos P, Merlino J, et al. Results of the predictors of response to CRT (PROSPECT) trial. CIRCULATION. 2008;117(20):2608–16.
IEEE
[1]
E. S. Chung et al., “Results of the predictors of response to CRT (PROSPECT) trial,” CIRCULATION, vol. 117, no. 20, pp. 2608–2616, 2008.
@article{745665,
  abstract     = {Background-Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters to predict CRT response.

Methods and Results-Fifty-three centers in Europe, Hong Kong, and the United States enrolled 498 patients with standard CRT indications (New York Heart Association class III or IV heart failure, left ventricular ejection fraction <= 35%, QRS >= 130 ms, stable medical regimen). Twelve echocardiographic parameters of dyssynchrony, based on both conventional and tissue Doppler-based methods, were evaluated after site training in acquisition methods and blinded core laboratory analysis. Indicators of positive CRT response were improved clinical composite score and >= 15% reduction in left ventricular end-systolic volume at 6 months. Clinical composite score was improved in 69% of 426 patients, whereas left ventricular end-systolic volume decreased >= 15% in 56% of 286 patients with paired data. The ability of the 12 echocardiographic parameters to predict clinical composite score response varied widely, with sensitivity ranging from 6% to 74% and specificity ranging from 35% to 91%; for predicting left ventricular end-systolic volume response, sensitivity ranged from 9% to 77% and specificity from 31% to 93%. For all the parameters, the area under the receiver-operating characteristics curve for positive clinical or volume response to CRT was <= 0.62. There was large variability in the analysis of the dyssynchrony parameters.

Conclusion-Given the modest sensitivity and specificity in this multicenter setting despite training and central analysis, no single echocardiographic measure of dyssynchrony may be recommended to improve patient selection for CRT beyond current guidelines. Efforts aimed at reducing variability arising from technical and interpretative factors may improve the predictive power of these echocardiographic parameters in a broad clinical setting.},
  author       = {Chung, Eugene S. and Leon, Angel R. and Tavazzi, Luigi and Sun, Jing-Ping and Nihoyannopoulos, Petros and Merlino, John and Abraham, William T. and Ghio, Stefano and Leclercq, Christophe and Bax, Jeroen J. and Yu, Cheuk-Man and Gorcsan, John and Sutton, Martin St John and De Sutter, Johan and Murillo, Jaime},
  issn         = {0009-7322},
  journal      = {CIRCULATION},
  keywords     = {dyssynchrony,echocardiography,UPDATE,DIAGNOSIS,GUIDELINE,CARDIOMYOPATHY,STRAIN,Doppler,heart failure,pacemakers,TISSUE,LEFT-VENTRICULAR DYSSYNCHRONY,CARDIAC-RESYNCHRONIZATION THERAPY,CHRONIC HEART-FAILURE},
  language     = {eng},
  number       = {20},
  pages        = {2608--2616},
  title        = {Results of the predictors of response to CRT (PROSPECT) trial},
  url          = {http://dx.doi.org/10.1161/CIRCULATIONAHA.107.743120},
  volume       = {117},
  year         = {2008},
}

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