Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy
- Author
- Nina Ajmone Marsan, Gabe B. Bleeker, Claudia Ypenburg, Stefano Ghio, Nico R. Van De Veire, Eduard R. Holman, Ernst E. Van Der Wall, L. Tavazzi, Martin J. Schalij and Jeroen J. Bax
- Organization
- Abstract
- RT3DE Predicts Acute Response to CRT. Objective: To evaluate the value of real-time three-dimensional echocardiography (RT3DE) to predict acute response to cardiac resynchronization therapy (CRT). Methods: Sixty consecutive heart failure patients scheduled for CRT were included. RT3DE was performed before and within 48 hours after pacemaker implantation to calculate both left ventricular (LV) volumes and LV dyssynchrony. LV dyssynchrony was defined as the standard deviation of the time taken to reach the minimum systolic volume for 16 LV segments (referred to as the systolic dyssynchrony index, SDI). Patients were subsequently divided into acute responders or nonresponders, based on a reduction >= 15% in LV end-systolic volume immediately after CRT. Results: Four patients (7%) were excluded from further analysis because of either suboptimal apical acquisitions or significant translation artifacts. Out of the remaining 56 patients, 35 patients (63%) were classified as acute responders. Baseline characteristics were similar between responders and nonresponders, except for the SDI, which was larger in responders. Moreover, responders demonstrated a significant reduction of SDI immediately after CRT (from 9.7 +/- 4.1% to 3.6 +/- 1.8%, P < 0.0001), whereas SDI did not change in nonresponders (3.4 +/- 1.8% vs 3.1 +/- 1.1%, NS). ROC curve analysis revealed that a cut-off value for SDI of 5.6% yielded a sensitivity of 88% with a specificity of 86% to predict acute echocardiographic response to CRT (AUC 0.96). Conclusion: RT3DE is highly predictive for acute response to CRT (sensitivity 88% and specificity 86%). In addition, RT3DE allows assessment of changes in LV volumes and LV ejection fraction before and after CRT implantation.
- Keywords
- ASYNCHRONY PREDICTS, IMAGES, RADIAL STRAIN, QRS DURATION, SYNCHRONICITY, IMPROVEMENT, HEART-FAILURE
Downloads
-
(...).pdf
- full text
- |
- UGent only
- |
- |
- 1.43 MB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-745273
- MLA
- Marsan, Nina Ajmone, et al. “Real-Time Three-Dimensional Echocardiography Permits Quantification of Left Ventricular Mechanical Dyssynchrony and Predicts Acute Response to Cardiac Resynchronization Therapy.” JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, vol. 19, no. 4, 2008, pp. 392–99, doi:10.1111/j.1540-8167.2007.01056.x.
- APA
- Marsan, N. A., Bleeker, G. B., Ypenburg, C., Ghio, S., Van De Veire, N. R., Holman, E. R., … Bax, J. J. (2008). Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 19(4), 392–399. https://doi.org/10.1111/j.1540-8167.2007.01056.x
- Chicago author-date
- Marsan, Nina Ajmone, Gabe B. Bleeker, Claudia Ypenburg, Stefano Ghio, Nico R. Van De Veire, Eduard R. Holman, Ernst E. Van Der Wall, L. Tavazzi, Martin J. Schalij, and Jeroen J. Bax. 2008. “Real-Time Three-Dimensional Echocardiography Permits Quantification of Left Ventricular Mechanical Dyssynchrony and Predicts Acute Response to Cardiac Resynchronization Therapy.” JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 19 (4): 392–99. https://doi.org/10.1111/j.1540-8167.2007.01056.x.
- Chicago author-date (all authors)
- Marsan, Nina Ajmone, Gabe B. Bleeker, Claudia Ypenburg, Stefano Ghio, Nico R. Van De Veire, Eduard R. Holman, Ernst E. Van Der Wall, L. Tavazzi, Martin J. Schalij, and Jeroen J. Bax. 2008. “Real-Time Three-Dimensional Echocardiography Permits Quantification of Left Ventricular Mechanical Dyssynchrony and Predicts Acute Response to Cardiac Resynchronization Therapy.” JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 19 (4): 392–399. doi:10.1111/j.1540-8167.2007.01056.x.
- Vancouver
- 1.Marsan NA, Bleeker GB, Ypenburg C, Ghio S, Van De Veire NR, Holman ER, et al. Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. 2008;19(4):392–9.
- IEEE
- [1]N. A. Marsan et al., “Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy,” JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, vol. 19, no. 4, pp. 392–399, 2008.
@article{745273, abstract = {{RT3DE Predicts Acute Response to CRT. Objective: To evaluate the value of real-time three-dimensional echocardiography (RT3DE) to predict acute response to cardiac resynchronization therapy (CRT). Methods: Sixty consecutive heart failure patients scheduled for CRT were included. RT3DE was performed before and within 48 hours after pacemaker implantation to calculate both left ventricular (LV) volumes and LV dyssynchrony. LV dyssynchrony was defined as the standard deviation of the time taken to reach the minimum systolic volume for 16 LV segments (referred to as the systolic dyssynchrony index, SDI). Patients were subsequently divided into acute responders or nonresponders, based on a reduction >= 15% in LV end-systolic volume immediately after CRT. Results: Four patients (7%) were excluded from further analysis because of either suboptimal apical acquisitions or significant translation artifacts. Out of the remaining 56 patients, 35 patients (63%) were classified as acute responders. Baseline characteristics were similar between responders and nonresponders, except for the SDI, which was larger in responders. Moreover, responders demonstrated a significant reduction of SDI immediately after CRT (from 9.7 +/- 4.1% to 3.6 +/- 1.8%, P < 0.0001), whereas SDI did not change in nonresponders (3.4 +/- 1.8% vs 3.1 +/- 1.1%, NS). ROC curve analysis revealed that a cut-off value for SDI of 5.6% yielded a sensitivity of 88% with a specificity of 86% to predict acute echocardiographic response to CRT (AUC 0.96). Conclusion: RT3DE is highly predictive for acute response to CRT (sensitivity 88% and specificity 86%). In addition, RT3DE allows assessment of changes in LV volumes and LV ejection fraction before and after CRT implantation.}}, author = {{Marsan, Nina Ajmone and Bleeker, Gabe B. and Ypenburg, Claudia and Ghio, Stefano and Van De Veire, Nico R. and Holman, Eduard R. and Van Der Wall, Ernst E. and Tavazzi, L. and Schalij, Martin J. and Bax, Jeroen J.}}, issn = {{1045-3873}}, journal = {{JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY}}, keywords = {{ASYNCHRONY PREDICTS,IMAGES,RADIAL STRAIN,QRS DURATION,SYNCHRONICITY,IMPROVEMENT,HEART-FAILURE}}, language = {{eng}}, number = {{4}}, pages = {{392--399}}, title = {{Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy}}, url = {{http://doi.org/10.1111/j.1540-8167.2007.01056.x}}, volume = {{19}}, year = {{2008}}, }
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: