- Author
- J. Mullo, J. Bousquet, Claus Bachert (UGent) , W. G. Canonica, A. Gimenez-Arnau, M. L. Kowalski, E. Marti-Guadano, M. Maurer, C. Picado, G. Scadding and Paul Van Cauwenberge (UGent)
- Organization
- Abstract
- Histamine is the primary mediator involved the pathophysiology of allergic rhinitis and chronic urticaria, and this explains the prominent role that histamine H-1-receptor antagonists have in the treatment of these disorders. However, histamine is clearly not the only mediator involved in the inflammatory cascade. There is an emerging view that drugs which can inhibit a broader range of inflammatory processes may prove to be more effective in providing symptomatic relief in both allergic rhinitis and chronic urticaria. This is an important consideration of the Allergic Rhinitis and its Impact on Asthma (ARIA) initiative which provides a scientific basis for defining what are the desirable properties of an 'ideal' antihistamine. In this review of rupatadine, a newer dual inhibitor of histamine H-1- and PAF-receptors, we evaluate the evidence for a mechanism of action which includes anti-inflammatory effects in addition to a powerful inhibition of H-1- and PAF-receptors. We assess this in relation to the clinical efficacy (particularly the speed of onset of action) and safety of rupatadine, and importantly its longer term utility in everyday life. In clinical trials, rupatadine has been shown to be an effective and well-tolerated treatment for allergic rhinitis and chronic idiopathic urticaria (CIU). It has a fast onset of action, producing rapid symptomatic relief, and it also has an extended duration of clinical activity which allows once-daily administration. In comparative clinical trials rupatadine was shown to be at least as effective as drugs such as loratadine, cetirizine, desloratadine and ebastine in reducing allergic symptoms in adult/adolescent patients with seasonal, perennial or persistent allergic rhinitis. Importantly, rupatadine demonstrated no adverse cardiovascular effects in preclinical or extensive clinical testing, nor negative significant effects on cognition or psychomotor performance (including a practical driving study). It improved the overall well-being of patients with allergic rhinitis or CIU based on findings from quality of life questionnaires and patient global rating scores in clinical trials. Thus, rupatadine is a recently introduced dual inhibitor of histamine H-1- and PAF-receptors, which has been shown to be an effective and generally well-tolerated treatment for allergic rhinitis and chronic urticaria. It possesses a broader profile of anti-inflammatory properties inhibiting both inflammatory cells and a range of mediators involved in the early- and late-phase inflammatory response, but the clinical relevance of these effects remain to be clarified.
- Keywords
- PLATELET-ACTIVATING-FACTOR, CHRONIC IDIOPATHIC URTICARIA, PAF-receptor antagonists, H-1-receptor antagonists, chronic urticaria, antiallergic antihistamines, allergic rhinitis, ANTIGEN CHALLENGE, PHARMACOLOGICAL PROFILE, EAACI/GA(2)LEN/EDF GUIDELINE, 10 MG, DOUBLE-BLIND, CELL LINE HMC-1, HEALTHY-VOLUNTEERS, rupatadine, TNF-ALPHA RELEASE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-745173
- MLA
- Mullo, J., et al. “Rupatadine in Allergic Rhinitis and Chronic Urticaria.” ALLERGY, vol. 63, no. Suppl. 87, 2008, pp. 5–28.
- APA
- Mullo, J., Bousquet, J., Bachert, C., Canonica, W. G., Gimenez-Arnau, A., Kowalski, M. L., … Van Cauwenberge, P. (2008). Rupatadine in allergic rhinitis and chronic urticaria. ALLERGY, 63(Suppl. 87), 5–28.
- Chicago author-date
- Mullo, J., J. Bousquet, Claus Bachert, W. G. Canonica, A. Gimenez-Arnau, M. L. Kowalski, E. Marti-Guadano, et al. 2008. “Rupatadine in Allergic Rhinitis and Chronic Urticaria.” ALLERGY 63 (Suppl. 87): 5–28.
- Chicago author-date (all authors)
- Mullo, J., J. Bousquet, Claus Bachert, W. G. Canonica, A. Gimenez-Arnau, M. L. Kowalski, E. Marti-Guadano, M. Maurer, C. Picado, G. Scadding, and Paul Van Cauwenberge. 2008. “Rupatadine in Allergic Rhinitis and Chronic Urticaria.” ALLERGY 63 (Suppl. 87): 5–28.
- Vancouver
- 1.Mullo J, Bousquet J, Bachert C, Canonica WG, Gimenez-Arnau A, Kowalski ML, et al. Rupatadine in allergic rhinitis and chronic urticaria. ALLERGY. 2008;63(Suppl. 87):5–28.
- IEEE
- [1]J. Mullo et al., “Rupatadine in allergic rhinitis and chronic urticaria,” ALLERGY, vol. 63, no. Suppl. 87, pp. 5–28, 2008.
@article{745173, abstract = {{Histamine is the primary mediator involved the pathophysiology of allergic rhinitis and chronic urticaria, and this explains the prominent role that histamine H-1-receptor antagonists have in the treatment of these disorders. However, histamine is clearly not the only mediator involved in the inflammatory cascade. There is an emerging view that drugs which can inhibit a broader range of inflammatory processes may prove to be more effective in providing symptomatic relief in both allergic rhinitis and chronic urticaria. This is an important consideration of the Allergic Rhinitis and its Impact on Asthma (ARIA) initiative which provides a scientific basis for defining what are the desirable properties of an 'ideal' antihistamine. In this review of rupatadine, a newer dual inhibitor of histamine H-1- and PAF-receptors, we evaluate the evidence for a mechanism of action which includes anti-inflammatory effects in addition to a powerful inhibition of H-1- and PAF-receptors. We assess this in relation to the clinical efficacy (particularly the speed of onset of action) and safety of rupatadine, and importantly its longer term utility in everyday life. In clinical trials, rupatadine has been shown to be an effective and well-tolerated treatment for allergic rhinitis and chronic idiopathic urticaria (CIU). It has a fast onset of action, producing rapid symptomatic relief, and it also has an extended duration of clinical activity which allows once-daily administration. In comparative clinical trials rupatadine was shown to be at least as effective as drugs such as loratadine, cetirizine, desloratadine and ebastine in reducing allergic symptoms in adult/adolescent patients with seasonal, perennial or persistent allergic rhinitis. Importantly, rupatadine demonstrated no adverse cardiovascular effects in preclinical or extensive clinical testing, nor negative significant effects on cognition or psychomotor performance (including a practical driving study). It improved the overall well-being of patients with allergic rhinitis or CIU based on findings from quality of life questionnaires and patient global rating scores in clinical trials. Thus, rupatadine is a recently introduced dual inhibitor of histamine H-1- and PAF-receptors, which has been shown to be an effective and generally well-tolerated treatment for allergic rhinitis and chronic urticaria. It possesses a broader profile of anti-inflammatory properties inhibiting both inflammatory cells and a range of mediators involved in the early- and late-phase inflammatory response, but the clinical relevance of these effects remain to be clarified.}}, author = {{Mullo, J. and Bousquet, J. and Bachert, Claus and Canonica, W. G. and Gimenez-Arnau, A. and Kowalski, M. L. and Marti-Guadano, E. and Maurer, M. and Picado, C. and Scadding, G. and Van Cauwenberge, Paul}}, issn = {{0105-4538}}, journal = {{ALLERGY}}, keywords = {{PLATELET-ACTIVATING-FACTOR,CHRONIC IDIOPATHIC URTICARIA,PAF-receptor antagonists,H-1-receptor antagonists,chronic urticaria,antiallergic antihistamines,allergic rhinitis,ANTIGEN CHALLENGE,PHARMACOLOGICAL PROFILE,EAACI/GA(2)LEN/EDF GUIDELINE,10 MG,DOUBLE-BLIND,CELL LINE HMC-1,HEALTHY-VOLUNTEERS,rupatadine,TNF-ALPHA RELEASE}}, language = {{eng}}, number = {{Suppl. 87}}, pages = {{5--28}}, title = {{Rupatadine in allergic rhinitis and chronic urticaria}}, volume = {{63}}, year = {{2008}}, }