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Benign retroperitoneal schwannoma presenting as colitis: A case report

(2007) WORLD JOURNAL OF GASTROENTEROLOGY. 13(41). p.5521-5524
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Abstract
We report a case of a patient presenting with clinical , radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed, which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwannoma. These neural sheath tumors rarely occur in the retroperitoneum. They are usually asymptomatic but as they enlarge they may compress adjacent structures, which leads to a wide spectrum of nonspecific symptoms, including lumbar pain, headache, secondary hypertension, abdominal pain and renal colicky pain. CT and MR findings show characteristic features, but none are specific. Schwannoma can be isolated sporadic lesions, or associated with schwannomatosis or neurofibromatosis type II (NF2). Although they vary in biological and clinical behavior, their presence is, in nearly every case, due to alterations or absence of the NF2 gene, which is involved in the growth regulation of Schwann cells. Both conditions were excluded by thorough mutation analysis. Diagnosis is based on histopathological examination and immunohistochemistry. Total excision is therapeutic and has a good prognosis. Schwannomatosis and NF2 should be excluded through clinical diagnostic criteria. Genetic testing of NF2 is probably not justified in the presence of a solitary retroperitoneal schwannoma.
Keywords
schwannoma, retroperitoneum, neurofibromatosis, colitis, DIAGNOSIS, NEURILEMOMA, NEUROFIBROMAS, MR FINDINGS, S-100 PROTEIN, SOFT-TISSUE TUMORS

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MLA
Fass, Gary et al. “Benign Retroperitoneal Schwannoma Presenting as Colitis: A Case Report.” WORLD JOURNAL OF GASTROENTEROLOGY 13.41 (2007): 5521–5524. Print.
APA
Fass, G., Hossey, D., Nyst, M., Smets, D., Saligheh, E. N., Duttmann, R., Claes, K., et al. (2007). Benign retroperitoneal schwannoma presenting as colitis: A case report. WORLD JOURNAL OF GASTROENTEROLOGY, 13(41), 5521–5524.
Chicago author-date
Fass, Gary, Didier Hossey, Michel Nyst, Dirk Smets, Esmail Najar Saligheh, Ruth Duttmann, Kathleen Claes, and Pierre Mendes da Costa. 2007. “Benign Retroperitoneal Schwannoma Presenting as Colitis: A Case Report.” World Journal of Gastroenterology 13 (41): 5521–5524.
Chicago author-date (all authors)
Fass, Gary, Didier Hossey, Michel Nyst, Dirk Smets, Esmail Najar Saligheh, Ruth Duttmann, Kathleen Claes, and Pierre Mendes da Costa. 2007. “Benign Retroperitoneal Schwannoma Presenting as Colitis: A Case Report.” World Journal of Gastroenterology 13 (41): 5521–5524.
Vancouver
1.
Fass G, Hossey D, Nyst M, Smets D, Saligheh EN, Duttmann R, et al. Benign retroperitoneal schwannoma presenting as colitis: A case report. WORLD JOURNAL OF GASTROENTEROLOGY. 2007;13(41):5521–4.
IEEE
[1]
G. Fass et al., “Benign retroperitoneal schwannoma presenting as colitis: A case report,” WORLD JOURNAL OF GASTROENTEROLOGY, vol. 13, no. 41, pp. 5521–5524, 2007.
@article{744012,
  abstract     = {We report a case of a patient presenting with clinical , radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed, which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwannoma. These neural sheath tumors rarely occur in the retroperitoneum. They are usually asymptomatic but as they enlarge they may compress adjacent structures, which leads to a wide spectrum of nonspecific symptoms, including lumbar pain, headache, secondary hypertension, abdominal pain and renal colicky pain. CT and MR findings show characteristic features, but none are specific. Schwannoma can be isolated sporadic lesions, or associated with schwannomatosis or neurofibromatosis type II (NF2). Although they vary in biological and clinical behavior, their presence is, in nearly every case, due to alterations or absence of the NF2 gene, which is involved in the growth regulation of Schwann cells. Both conditions were excluded by thorough mutation analysis. Diagnosis is based on histopathological examination and immunohistochemistry. Total excision is therapeutic and has a good prognosis. Schwannomatosis and NF2 should be excluded through clinical diagnostic criteria. Genetic testing of NF2 is probably not justified in the presence of a solitary retroperitoneal schwannoma.},
  author       = {Fass, Gary and Hossey, Didier and Nyst, Michel and Smets, Dirk and Saligheh, Esmail Najar and Duttmann, Ruth and Claes, Kathleen and da Costa, Pierre Mendes},
  issn         = {1007-9327},
  journal      = {WORLD JOURNAL OF GASTROENTEROLOGY},
  keywords     = {schwannoma,retroperitoneum,neurofibromatosis,colitis,DIAGNOSIS,NEURILEMOMA,NEUROFIBROMAS,MR FINDINGS,S-100 PROTEIN,SOFT-TISSUE TUMORS},
  language     = {eng},
  number       = {41},
  pages        = {5521--5524},
  title        = {Benign retroperitoneal schwannoma presenting as colitis: A case report},
  volume       = {13},
  year         = {2007},
}

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