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Chronic obstructive pulmonary disease as a risk factor for stroke-related seizures

Jacques De Reuck UGent, P. Proot and Georges Van Maele UGent (2007) EUROPEAN JOURNAL OF NEUROLOGY. 14(9). p.989-992
abstract
Chronic obstructive pulmonary disease (COPD) is a risk factor for cardiovascular disorders and different types of stroke. The present retrospective study investigates whether COPD is also a risk factor for the development of seizures in stroke patients. The study population consisted of 237 patients with stroke-related seizures. The control population was composed of 939 patients, admitted for a stroke between 2002 and 2004 and who did not develop epileptic spells on a follow up of 2 years. The stroke type and aetiology, and the vascular risk factors, including COPD, were compared. The seizure patients were older (P = 0.009) and had more arterial hypertension (P = 0.046) and cardiac-embolic strokes (P = 0.045) than the control group. On logistic regression only partial anterior circulation syndrome/infarct (PACS/I) and COPD (P < 0.001) emerged as independent risk factors for the development of seizures in stroke patients. The occurrence of seizures was not related to the severity of the COPD or to its type of treatment. The present study confirms that seizures occur most frequently in patients with a PACS/I. Although we were unable to demonstrate why COPD is a risk factor for seizures in stroke patients, its frequent associated nocturnal oxygen desaturation seems to be the most plausible explanation. Further prospective are needed to assess the role of COPD as a possible independent risk factor for stroke-related seizures.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
keyword
COPD PATIENTS, CARDIOVASCULAR-DISEASE, EPILEPSY, SLEEP, DESATURATION, INFARCTION, MORTALITY, chronic obstructive pulmonary disease, COPD medication, stroke aetiology, stroke type, stroke-related seizures, LUNG-FUNCTION, ISCHEMIC-STROKE, TERM OXYGEN-THERAPY, vascular risk factors
journal title
EUROPEAN JOURNAL OF NEUROLOGY
Eur. J. Neurol.
volume
14
issue
9
pages
989 - 992
Web of Science type
Article
Web of Science id
000248963200017
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.58 (2007)
JCR rank
47/146 (2007)
JCR quartile
2 (2007)
ISSN
1351-5101
DOI
10.1111/j.1468-1331.2007.01829.x
language
English
UGent publication?
yes
classification
A1
id
743735
handle
http://hdl.handle.net/1854/LU-743735
date created
2009-09-09 09:00:39
date last changed
2015-06-17 11:16:59
@article{743735,
  abstract     = {Chronic obstructive pulmonary disease (COPD) is a risk factor for cardiovascular disorders and different types of stroke. The present retrospective study investigates whether COPD is also a risk factor for the development of seizures in stroke patients. The study population consisted of 237 patients with stroke-related seizures. The control population was composed of 939 patients, admitted for a stroke between 2002 and 2004 and who did not develop epileptic spells on a follow up of 2 years. The stroke type and aetiology, and the vascular risk factors, including COPD, were compared. The seizure patients were older (P = 0.009) and had more arterial hypertension (P = 0.046) and cardiac-embolic strokes (P = 0.045) than the control group. On logistic regression only partial anterior circulation syndrome/infarct (PACS/I) and COPD (P {\textlangle} 0.001) emerged as independent risk factors for the development of seizures in stroke patients. The occurrence of seizures was not related to the severity of the COPD or to its type of treatment. The present study confirms that seizures occur most frequently in patients with a PACS/I. Although we were unable to demonstrate why COPD is a risk factor for seizures in stroke patients, its frequent associated nocturnal oxygen desaturation seems to be the most plausible explanation. Further prospective are needed to assess the role of COPD as a possible independent risk factor for stroke-related seizures.},
  author       = {De Reuck, Jacques and Proot, P. and Van Maele, Georges},
  issn         = {1351-5101},
  journal      = {EUROPEAN JOURNAL OF NEUROLOGY},
  keyword      = {COPD PATIENTS,CARDIOVASCULAR-DISEASE,EPILEPSY,SLEEP,DESATURATION,INFARCTION,MORTALITY,chronic obstructive pulmonary disease,COPD medication,stroke aetiology,stroke type,stroke-related seizures,LUNG-FUNCTION,ISCHEMIC-STROKE,TERM OXYGEN-THERAPY,vascular risk factors},
  language     = {eng},
  number       = {9},
  pages        = {989--992},
  title        = {Chronic obstructive pulmonary disease as a risk factor for stroke-related seizures},
  url          = {http://dx.doi.org/10.1111/j.1468-1331.2007.01829.x},
  volume       = {14},
  year         = {2007},
}

Chicago
De Reuck, Jacques, P. Proot, and Georges Van Maele. 2007. “Chronic Obstructive Pulmonary Disease as a Risk Factor for Stroke-related Seizures.” European Journal of Neurology 14 (9): 989–992.
APA
De Reuck, J., Proot, P., & Van Maele, G. (2007). Chronic obstructive pulmonary disease as a risk factor for stroke-related seizures. EUROPEAN JOURNAL OF NEUROLOGY, 14(9), 989–992.
Vancouver
1.
De Reuck J, Proot P, Van Maele G. Chronic obstructive pulmonary disease as a risk factor for stroke-related seizures. EUROPEAN JOURNAL OF NEUROLOGY. 2007;14(9):989–92.
MLA
De Reuck, Jacques, P. Proot, and Georges Van Maele. “Chronic Obstructive Pulmonary Disease as a Risk Factor for Stroke-related Seizures.” EUROPEAN JOURNAL OF NEUROLOGY 14.9 (2007): 989–992. Print.