Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
- Author
- Idoya Lahortiga, Kim De Keersmaecker, Pieter Van Vlierberghe (UGent) , Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Franki Speleman (UGent) , Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules PP Meijerink and Jan Cools
- Organization
- Abstract
- We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
- Keywords
- PATHOGENESIS, CANCER, GENOME, C-MYB
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-742825
- MLA
- Lahortiga, Idoya, et al. “Duplication of the MYB Oncogene in T Cell Acute Lymphoblastic Leukemia.” NATURE GENETICS, vol. 39, no. 5, 2007, pp. 593–95, doi:10.1038/ng2025.
- APA
- Lahortiga, I., De Keersmaecker, K., Van Vlierberghe, P., Graux, C., Cauwelier, B., Lambert, F., … Cools, J. (2007). Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. NATURE GENETICS, 39(5), 593–595. https://doi.org/10.1038/ng2025
- Chicago author-date
- Lahortiga, Idoya, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, et al. 2007. “Duplication of the MYB Oncogene in T Cell Acute Lymphoblastic Leukemia.” NATURE GENETICS 39 (5): 593–95. https://doi.org/10.1038/ng2025.
- Chicago author-date (all authors)
- Lahortiga, Idoya, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Franki Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules PP Meijerink, and Jan Cools. 2007. “Duplication of the MYB Oncogene in T Cell Acute Lymphoblastic Leukemia.” NATURE GENETICS 39 (5): 593–595. doi:10.1038/ng2025.
- Vancouver
- 1.Lahortiga I, De Keersmaecker K, Van Vlierberghe P, Graux C, Cauwelier B, Lambert F, et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. NATURE GENETICS. 2007;39(5):593–5.
- IEEE
- [1]I. Lahortiga et al., “Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia,” NATURE GENETICS, vol. 39, no. 5, pp. 593–595, 2007.
@article{742825, abstract = {{We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.}}, author = {{Lahortiga, Idoya and De Keersmaecker, Kim and Van Vlierberghe, Pieter and Graux, Carlos and Cauwelier, Barbara and Lambert, Frederic and Mentens, Nicole and Beverloo, H Berna and Pieters, Rob and Speleman, Franki and Odero, Maria D and Bauters, Marijke and Froyen, Guy and Marynen, Peter and Vandenberghe, Peter and Wlodarska, Iwona and Meijerink, Jules PP and Cools, Jan}}, issn = {{1061-4036}}, journal = {{NATURE GENETICS}}, keywords = {{PATHOGENESIS,CANCER,GENOME,C-MYB}}, language = {{eng}}, number = {{5}}, pages = {{593--595}}, title = {{Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia}}, url = {{http://doi.org/10.1038/ng2025}}, volume = {{39}}, year = {{2007}}, }
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