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Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

(2007) NATURE GENETICS. 39(5). p.593-595
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Abstract
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
Keywords
PATHOGENESIS, CANCER, GENOME, C-MYB

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MLA
Lahortiga, Idoya et al. “Duplication of the MYB Oncogene in T Cell Acute Lymphoblastic Leukemia.” NATURE GENETICS 39.5 (2007): 593–595. Print.
APA
Lahortiga, I., De Keersmaecker, K., Van Vlierberghe, P., Graux, C., Cauwelier, B., Lambert, F., Mentens, N., et al. (2007). Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. NATURE GENETICS, 39(5), 593–595.
Chicago author-date
Lahortiga, Idoya, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, et al. 2007. “Duplication of the MYB Oncogene in T Cell Acute Lymphoblastic Leukemia.” Nature Genetics 39 (5): 593–595.
Chicago author-date (all authors)
Lahortiga, Idoya, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Franki Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules PP Meijerink, and Jan Cools. 2007. “Duplication of the MYB Oncogene in T Cell Acute Lymphoblastic Leukemia.” Nature Genetics 39 (5): 593–595.
Vancouver
1.
Lahortiga I, De Keersmaecker K, Van Vlierberghe P, Graux C, Cauwelier B, Lambert F, et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. NATURE GENETICS. 2007;39(5):593–5.
IEEE
[1]
I. Lahortiga et al., “Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia,” NATURE GENETICS, vol. 39, no. 5, pp. 593–595, 2007.
@article{742825,
  abstract     = {We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.},
  author       = {Lahortiga, Idoya and De Keersmaecker, Kim and Van Vlierberghe, Pieter and Graux, Carlos and Cauwelier, Barbara and Lambert, Frederic and Mentens, Nicole and Beverloo, H Berna and Pieters, Rob and Speleman, Franki and Odero, Maria D and Bauters, Marijke and Froyen, Guy and Marynen, Peter and Vandenberghe, Peter and Wlodarska, Iwona and Meijerink, Jules PP and Cools, Jan},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keywords     = {PATHOGENESIS,CANCER,GENOME,C-MYB},
  language     = {eng},
  number       = {5},
  pages        = {593--595},
  title        = {Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.1038/ng2025},
  volume       = {39},
  year         = {2007},
}

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