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Proxy-reported health-related quality of life of patients with juvenile idiopathic arthritis: Pediatric rheumatology international trials organization multinational quality of life cohort study

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Abstract
Objective. To investigate the proxy-reported health-related quality of life (HRQOL) and its determinants in patients with juvenile idiopathic arthritis (JIA). Methods. In this multinational, multicenter, cross-sectional study, HRQOL of patients with JIA was assessed through the Child Health Questionnaire (CHQ) and was compared with that of healthy children of similar age from the same geographic area. of joint inflammation, Childhood Health Assessment Questionnaire (CHAQ), and erythrocyte sedimentation rate. Results. A total of 6,639 participants (3,324 with JIA and 3,315 healthy) were enrolled from 32 countries. The mean SD physical and psychosocial summary scores of the CHQ were significantly lower in patients with JIA than in healthy children (physical: 44.5 +/- 10.6 versus 54.6 +/- 4.0, P < 0.0001; psychosocial: 47.6 +/- 8.7 versus 51.9 +/- 7.59 P < 0.0001), with the physical well-being domain being most impaired. Patients with persistent oligoarthritis had better HRQOL compared with other subtypes, whereas HRQOL was similar across patients with systemic arthritis, polyarthritis, and extended oligoarthritis. A CHAQ score > 1 and a pain intensity rating > 3.4 cm on a 10-cm visual analog scale were the strongest determinants of poorer HRQOL in the physical and psychosocial domains, respectively. Conclusion. We found that patients with JIA have a significant impairment of their HRQOL compared with healthy peers, particularly in the physical domain. Physical well-being was mostly affected by the level of functional impairment, whereas the intensity of pain had the greatest influence on psychosocial health.
Keywords
health-related quality of life, juvenile idiopathic arthritis, IMPROVEMENT, RELIABILITY, INDEX, DISEASES, OUTCOMES, FUNCTIONAL STATUS, CHILDREN, CROSS-CULTURAL ADAPTATION, PRELIMINARY DEFINITION, ITALIAN INCEPTION COHORTS, disability

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Chicago
Oliveira, Sheila, Angelo Ravelli, Angela Pistorio, Esteban Castell, Clara Malattia, Anne Marie Prieur, Claudia Saad-Magalhaes, et al. 2007. “Proxy-reported Health-related Quality of Life of Patients with Juvenile Idiopathic Arthritis: Pediatric Rheumatology International Trials Organization Multinational Quality of Life Cohort Study.” Arthritis & Rheumatism-arthritis Care & Research 57 (1): 35–43.
APA
Oliveira, S., Ravelli, A., Pistorio, A., Castell, E., Malattia, C., Prieur, A. M., Saad-Magalhaes, C., et al. (2007). Proxy-reported health-related quality of life of patients with juvenile idiopathic arthritis: Pediatric rheumatology international trials organization multinational quality of life cohort study. ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 57(1), 35–43.
Vancouver
1.
Oliveira S, Ravelli A, Pistorio A, Castell E, Malattia C, Prieur AM, et al. Proxy-reported health-related quality of life of patients with juvenile idiopathic arthritis: Pediatric rheumatology international trials organization multinational quality of life cohort study. ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH. 2007;57(1):35–43.
MLA
Oliveira, Sheila, Angelo Ravelli, Angela Pistorio, et al. “Proxy-reported Health-related Quality of Life of Patients with Juvenile Idiopathic Arthritis: Pediatric Rheumatology International Trials Organization Multinational Quality of Life Cohort Study.” ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH 57.1 (2007): 35–43. Print.
@article{742448,
  abstract     = {Objective. To investigate the proxy-reported health-related quality of life (HRQOL) and its determinants in patients with juvenile idiopathic arthritis (JIA).

Methods. In this multinational, multicenter, cross-sectional study, HRQOL of patients with JIA was assessed through the Child Health Questionnaire (CHQ) and was compared with that of healthy children of similar age from the same geographic area. of joint inflammation, Childhood Health Assessment Questionnaire (CHAQ), and erythrocyte sedimentation rate.

Results. A total of 6,639 participants (3,324 with JIA and 3,315 healthy) were enrolled from 32 countries. The mean SD physical and psychosocial summary scores of the CHQ were significantly lower in patients with JIA than in healthy children (physical: 44.5 +/- 10.6 versus 54.6 +/- 4.0, P {\textlangle} 0.0001; psychosocial: 47.6 +/- 8.7 versus 51.9 +/- 7.59 P {\textlangle} 0.0001), with the physical well-being domain being most impaired. Patients with persistent oligoarthritis had better HRQOL compared with other subtypes, whereas HRQOL was similar across patients with systemic arthritis, polyarthritis, and extended oligoarthritis. A CHAQ score {\textrangle} 1 and a pain intensity rating {\textrangle} 3.4 cm on a 10-cm visual analog scale were the strongest determinants of poorer HRQOL in the physical and psychosocial domains, respectively.

Conclusion. We found that patients with JIA have a significant impairment of their HRQOL compared with healthy peers, particularly in the physical domain. Physical well-being was mostly affected by the level of functional impairment, whereas the intensity of pain had the greatest influence on psychosocial health.},
  author       = {Oliveira, Sheila and Ravelli, Angelo and Pistorio, Angela and Castell, Esteban and Malattia, Clara and Prieur, Anne Marie and Saad-Magalhaes, Claudia and Murray, Kevin J. and Bae, Sang-Cheol and Joos, Rik and Foeldvari, Ivan and Duarte-Salazar, Carolina and Wulffraat, Nico and Lahdenne, Pekka and Dolezalova, Pavla and de Inocencio, Jaime and Kanakoudi-Tsakalidou, Florence and Hofer, Michael and Nikishina, Irina and Ozdogan, Huri and Hashkes, Philip J. and Landgraf, Jeanne M. and Martini, Alberto and Ruperto, Nicolino},
  issn         = {0004-3591},
  journal      = {ARTHRITIS \& RHEUMATISM-ARTHRITIS CARE \& RESEARCH},
  keyword      = {health-related quality of life,juvenile idiopathic arthritis,IMPROVEMENT,RELIABILITY,INDEX,DISEASES,OUTCOMES,FUNCTIONAL STATUS,CHILDREN,CROSS-CULTURAL ADAPTATION,PRELIMINARY DEFINITION,ITALIAN INCEPTION COHORTS,disability},
  language     = {eng},
  number       = {1},
  pages        = {35--43},
  title        = {Proxy-reported health-related quality of life of patients with juvenile idiopathic arthritis: Pediatric rheumatology international trials organization multinational quality of life cohort study},
  url          = {http://dx.doi.org/10.1002/art.22473},
  volume       = {57},
  year         = {2007},
}

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