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Prevalence of Low Bone Mass in Relation to Estrogen Treatment and Body Composition in Male-to-Female Transsexual Persons

Guy T'Sjoen UGent, Steven Weyers UGent, Youri Taes UGent, Bruno Lapauw UGent, Kaatje Toye UGent, Stefan Goemaere UGent and Jean Kaufman UGent (2009) JOURNAL OF CLINICAL DENSITOMETRY. 12(3). p.306-313
abstract
Bone health is a parameter of interest in the daily follow-up of male-to-female (M -> F) transsexual persons both before and after sex reassignment surgery (SRS) due to an intensely changing hormonal milieu. We have studied body composition, areal, geometric, and volumetric bone parameters, using DXA and peripheral quantitative computed tomography at different sites in 50 M -> F transsexual persons, at least 3 yr after the start of the hormonal treatment and I yr after SRS. In this cross-sectional study, hormone levels and markers of bone metabolism were assessed using immunoassays. Prevalence of low bone mass as defined by a Z-score <= -2.0 according to DXA criteria was 26% at lumbar spine and 2% at the total hip. We found no major differences in hormonal parameters between participants with a Z-score <= or > -2.0. Markers of bone turnover were comparable between subjects with, or without low bone mass, indicating a stable bone turnover at the time of investigation. No significant differences in bone size or density were observed between patients on transdermal vs. oral estrogens. Low bone mass is not uncommon in M -> F transsexual persons. Smaller bone size, and a strikingly lower muscle mass compared with men appear to underlie these findings.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
JOURNAL OF CLINICAL DENSITOMETRY
J. Clin. Densitom.
volume
12
issue
3
pages
306 - 313
Web of Science type
Article
Web of Science id
000268933700007
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
2.389 (2009)
JCR rank
63/104 (2009)
JCR quartile
3 (2009)
ISSN
1094-6950
language
English
UGent publication?
yes
classification
A1
id
741167
handle
http://hdl.handle.net/1854/LU-741167
date created
2009-09-07 10:34:45
date last changed
2009-09-07 12:05:12
@article{741167,
  abstract     = {Bone health is a parameter of interest in the daily follow-up of male-to-female (M -{\textrangle} F) transsexual persons both before and after sex reassignment surgery (SRS) due to an intensely changing hormonal milieu. We have studied body composition, areal, geometric, and volumetric bone parameters, using DXA and peripheral quantitative computed tomography at different sites in 50 M -{\textrangle} F transsexual persons, at least 3 yr after the start of the hormonal treatment and I yr after SRS. In this cross-sectional study, hormone levels and markers of bone metabolism were assessed using immunoassays. Prevalence of low bone mass as defined by a Z-score {\textlangle}= -2.0 according to DXA criteria was 26\% at lumbar spine and 2\% at the total hip. We found no major differences in hormonal parameters between participants with a Z-score {\textlangle}= or {\textrangle} -2.0. Markers of bone turnover were comparable between subjects with, or without low bone mass, indicating a stable bone turnover at the time of investigation. No significant differences in bone size or density were observed between patients on transdermal vs. oral estrogens. Low bone mass is not uncommon in M -{\textrangle} F transsexual persons. Smaller bone size, and a strikingly lower muscle mass compared with men appear to underlie these findings.},
  author       = {T'Sjoen, Guy and Weyers, Steven and Taes, Youri and Lapauw, Bruno and Toye, Kaatje and Goemaere, Stefan and Kaufman, Jean},
  issn         = {1094-6950},
  journal      = {JOURNAL OF CLINICAL DENSITOMETRY},
  language     = {eng},
  number       = {3},
  pages        = {306--313},
  title        = {Prevalence of Low Bone Mass in Relation to Estrogen Treatment and Body Composition in Male-to-Female Transsexual Persons},
  volume       = {12},
  year         = {2009},
}

Chicago
T’Sjoen, Guy, Steven Weyers, Youri Taes, Bruno Lapauw, Kaatje Toye, Stefan Goemaere, and Jean Kaufman. 2009. “Prevalence of Low Bone Mass in Relation to Estrogen Treatment and Body Composition in Male-to-Female Transsexual Persons.” Journal of Clinical Densitometry 12 (3): 306–313.
APA
T’Sjoen, G., Weyers, S., Taes, Y., Lapauw, B., Toye, K., Goemaere, S., & Kaufman, J. (2009). Prevalence of Low Bone Mass in Relation to Estrogen Treatment and Body Composition in Male-to-Female Transsexual Persons. JOURNAL OF CLINICAL DENSITOMETRY, 12(3), 306–313.
Vancouver
1.
T’Sjoen G, Weyers S, Taes Y, Lapauw B, Toye K, Goemaere S, et al. Prevalence of Low Bone Mass in Relation to Estrogen Treatment and Body Composition in Male-to-Female Transsexual Persons. JOURNAL OF CLINICAL DENSITOMETRY. 2009;12(3):306–13.
MLA
T’Sjoen, Guy, Steven Weyers, Youri Taes, et al. “Prevalence of Low Bone Mass in Relation to Estrogen Treatment and Body Composition in Male-to-Female Transsexual Persons.” JOURNAL OF CLINICAL DENSITOMETRY 12.3 (2009): 306–313. Print.