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We evaluated the PET performance of the GE SIGNA integrated PET/MR (SGINA) and adjusted potential post-filtering settings to harmonise image quality and quantitative accuracy between different PET-systems at our institution. METHODS: The NEMA NU 2-2007 protocol was followed for studying the PET performance of the SIGNA. The following measurements were performed: spatial resolution; scatter fraction, sensitivity; accuracy of correction for count losses and randoms. Furthermore, a NEMA image quality phantom was measured with and without simultaneous MR acquisition. The reconstructed spatial resolution (SR) and mean recovery coefficients (RCmean) in a TOF-OSEM reconstruction (VPFX, 2 subsets 28 iterations, no post-filtering) were determined using the method of [1]. Moreover, we analysed the effect of different post-filters to obtain a SR that is comparable to a Siemens Hirez PET/CT (HIREZ) at our institution. RESULTS: An transaxial SR of 4.1 and 5.1 mm in full width at half maximum (FWHM) was measured at 1 and 10 cm off-center. In the axial direction values were 6.1 and 6.9 mm, respectively. The system sensitivity was 21.8 cps/kBq along the center and 21.2 cps/kBq and at 10 cm off-center. The scatter fraction was 43.35%, and the peak noise-equivalent count rate was 216 kcps at 18.6 kBq/mL. The maximum absolute value of the relative count rate error due to dead-time losses and randoms was 2.92%. The average lung residual error was 1.6% for PET only and 2.1% for PET with simultaneous MR. The reconstructed SR of the TOF-OSEM reconstruction was 4.4 mm resulting in RCmeans of 0.87, 0.85, 0.80, 0.75, 0.70, 0.62 for the six spheres in the NEMA phantom. A Gaussian post-filtering with 5.4mm was necessary to match the SR of the SIGNA with the one of the HIREZ (7mm). CONCLUSION: The SIGNA offers a very promising PET performance and reconstructed SR which is crucial for lesion detectability and reduced partial volume effects. REFERENCES: [1] Hofheinz et al., “Effects of cold sphere walls in PET phantom measurements on the volume reproducing threshold.”, Med Phys 40:082503, 2013

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Chicago
Schramm, Georg, Kathleen Vunckx, Ester D’Hoe, Stefaan Vandenberghe, Steven Staelens, Koen Van Laere, Johan Nuyts, and Michel Koole. 2016. “GE Signa Integrated PET/MR: NEMA PET Performance Measurements.” In y of Nuclear Medicine and Medical Imaging 2016 Annual Meeting.
APA
Schramm, G., Vunckx, K., D’Hoe, E., Vandenberghe, S., Staelens, S., Van Laere, K., Nuyts, J., et al. (2016). GE Signa integrated PET/MR: NEMA PET performance measurements. y of Nuclear Medicine and Medical Imaging 2016 Annual Meeting. Presented at the Society of Nuclear Medicine and Medical Imaging 2016 Annual Meeting.
Vancouver
1.
Schramm G, Vunckx K, D’Hoe E, Vandenberghe S, Staelens S, Van Laere K, et al. GE Signa integrated PET/MR: NEMA PET performance measurements. y of Nuclear Medicine and Medical Imaging 2016 Annual Meeting. 2016.
MLA
Schramm, Georg, Kathleen Vunckx, Ester D’Hoe, et al. “GE Signa Integrated PET/MR: NEMA PET Performance Measurements.” y of Nuclear Medicine and Medical Imaging 2016 Annual Meeting. 2016. Print.
@inproceedings{7408950,
  abstract     = {We evaluated the PET performance of the GE SIGNA integrated PET/MR (SGINA) and adjusted potential post-filtering settings to harmonise image quality and quantitative accuracy between different PET-systems at our institution.
METHODS:
The NEMA NU 2-2007 protocol was followed for studying the PET performance of the SIGNA. The following measurements were performed: spatial resolution; scatter fraction, sensitivity; accuracy of  correction for count losses and randoms. Furthermore, a NEMA image quality phantom was measured with and without simultaneous MR acquisition. The reconstructed spatial resolution (SR) and mean recovery coefficients (RCmean) in a TOF-OSEM reconstruction (VPFX, 2 subsets 28 iterations, no post-filtering) were determined using the method of [1]. Moreover, we analysed the effect of different post-filters to obtain a SR  that is comparable to a Siemens Hirez PET/CT (HIREZ) at our institution. 
RESULTS:
An transaxial SR of 4.1 and 5.1 mm in full width at half maximum (FWHM) was measured at 1 and 10 cm off-center. In the axial direction values were 6.1 and 6.9 mm, respectively. The system sensitivity was 21.8 cps/kBq along the center and 21.2 cps/kBq and at 10 cm off-center. The scatter fraction was 43.35\%, and the peak noise-equivalent count rate was 216 kcps at 18.6 kBq/mL. The maximum absolute value of the relative count rate error due to dead-time losses and randoms was 2.92\%. The average lung residual error was 1.6\% for PET only and 2.1\% for PET with simultaneous MR. The reconstructed SR of the TOF-OSEM reconstruction was 4.4 mm resulting in RCmeans of 0.87, 0.85, 0.80, 0.75, 0.70, 0.62 for the six spheres in the NEMA phantom. A Gaussian post-filtering with 5.4mm was necessary to match the SR of the SIGNA with the one of the HIREZ (7mm).
CONCLUSION:
The SIGNA offers a very promising PET performance and reconstructed SR which is crucial for lesion detectability and reduced partial volume effects.
REFERENCES:
[1] Hofheinz et al., {\textquotedblleft}Effects of cold sphere walls in PET phantom measurements on the volume reproducing threshold.{\textquotedblright}, Med Phys 40:082503, 2013},
  author       = {Schramm, Georg and Vunckx, Kathleen and D'Hoe, Ester and Vandenberghe, Stefaan and Staelens, Steven and Van Laere, Koen and Nuyts, Johan and Koole, Michel},
  booktitle    = {y of Nuclear Medicine and Medical Imaging 2016 Annual Meeting},
  language     = {eng},
  location     = {San Diego, California, United States of America},
  title        = {GE Signa integrated PET/MR: NEMA PET performance measurements},
  year         = {2016},
}