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Use of functional neuroimaging and optogenetics to explore deep brain stimulation targets for the treatment of Parkinson's disease and epilepsy

Nathalie Van Den Berge (2016)
abstract
Deep brain stimulation (DBS) is a neurosurgical therapy for Parkinson’s disease and epilepsy. In DBS, an electrode is stereotactically implanted in a specific region of the brain and electrical pulses are delivered using a subcutaneous pacemaker-like stimulator. DBS-therapy has proven to effectively suppress tremor or seizures in pharmaco-resistant Parkinson’s disease and epilepsy patients respectively. It is most commonly applied in the subthalamic nucleus for Parkinson’s disease, or in the anterior thalamic nucleus for epilepsy. Despite the rapidly growing use of DBS at these classic brain structures, there are still non-responders to the treatment. This creates a need to explore other brain structures as potential DBS-targets. However, research in patients is restricted mainly because of ethical reasons. Therefore, in order to search for potential new DBS targets, animal research is indispensable. Previous animal studies of DBS-relevant circuitry largely relied on electrophysiological recordings at predefined brain areas with assumed relevance to DBS therapy. Due to their inherent regional biases, such experimental techniques prevent the identification of less recognized brain structures that might be suitable DBS targets. Therefore, functional neuroimaging techniques, such as functional Magnetic Resonance Imaging and Positron Emission Tomography, were used in this thesis because they allow to visualize and to analyze the whole brain during DBS. Additionally, optogenetics, a new technique that uses light instead of electricity, was employed to manipulate brain cells with unprecedented selectivity.
Please use this url to cite or link to this publication:
author
promoter
UGent, UGent and UGent
organization
alternative title
Gebruik van functionele beeldvorming en optogenetica voor de exploratie van doelwitten voor diepe hersenstimulatie bij de ziekte van Parkinson en epilepsie
year
type
dissertation
publication status
published
subject
keyword
Deep brain stimulation, Medical Imaging, Optogenetics, Parkinson's disease, Epilepsy
pages
XXXIX, 156 pages
publisher
Ghent University. Faculty of Engineering and Architecture
place of publication
Ghent, Belgium
defense location
Gent : Instituut der Wetenschappen (Jozef Plateaustraat 22, Jozef Plateauzaal)
defense date
2016-05-17 10:00
ISBN
9789085788997
language
English
UGent publication?
yes
classification
D1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7408769
handle
http://hdl.handle.net/1854/LU-7408769
date created
2016-06-24 17:20:59
date last changed
2017-01-16 10:51:28
@phdthesis{7408769,
  abstract     = {Deep brain stimulation (DBS) is a neurosurgical therapy for Parkinson{\textquoteright}s disease and epilepsy. In DBS, an electrode is stereotactically implanted in a specific region of the brain and electrical pulses are delivered using a subcutaneous pacemaker-like stimulator. DBS-therapy has proven to effectively suppress tremor or seizures in pharmaco-resistant Parkinson{\textquoteright}s disease and epilepsy patients respectively.  It is most commonly applied in the subthalamic nucleus for Parkinson{\textquoteright}s disease, or in the anterior thalamic nucleus for epilepsy. Despite the rapidly growing use of DBS at these classic brain structures, there are still non-responders to the treatment. This creates a need to explore other brain structures as potential DBS-targets. However, research in patients is restricted mainly because of ethical reasons. Therefore, in order to search for potential new DBS targets, animal research is indispensable. Previous animal studies of DBS-relevant circuitry largely relied on electrophysiological recordings at predefined brain areas with assumed relevance to DBS therapy. Due to their inherent regional biases, such experimental techniques prevent the identification of less recognized brain structures that might be suitable DBS targets. Therefore, functional neuroimaging techniques, such as functional Magnetic Resonance Imaging and Positron Emission Tomography, were used in this thesis because they allow to visualize and to analyze the whole brain during DBS. Additionally, optogenetics, a new technique that uses light instead of electricity, was employed to manipulate brain cells with unprecedented selectivity.},
  author       = {Van Den Berge, Nathalie},
  isbn         = {9789085788997},
  keyword      = {Deep brain stimulation,Medical Imaging,Optogenetics,Parkinson's disease,Epilepsy},
  language     = {eng},
  pages        = {XXXIX, 156},
  publisher    = {Ghent University. Faculty of Engineering and Architecture},
  school       = {Ghent University},
  title        = {Use of functional neuroimaging and optogenetics to explore deep brain stimulation targets for the treatment of Parkinson's disease and epilepsy},
  year         = {2016},
}

Chicago
Van Den Berge, Nathalie. 2016. “Use of Functional Neuroimaging and Optogenetics to Explore Deep Brain Stimulation Targets for the Treatment of Parkinson’s Disease and Epilepsy”. Ghent, Belgium: Ghent University. Faculty of Engineering and Architecture.
APA
Van Den Berge, N. (2016). Use of functional neuroimaging and optogenetics to explore deep brain stimulation targets for the treatment of Parkinson’s disease and epilepsy. Ghent University. Faculty of Engineering and Architecture, Ghent, Belgium.
Vancouver
1.
Van Den Berge N. Use of functional neuroimaging and optogenetics to explore deep brain stimulation targets for the treatment of Parkinson’s disease and epilepsy. [Ghent, Belgium]: Ghent University. Faculty of Engineering and Architecture; 2016.
MLA
Van Den Berge, Nathalie. “Use of Functional Neuroimaging and Optogenetics to Explore Deep Brain Stimulation Targets for the Treatment of Parkinson’s Disease and Epilepsy.” 2016 : n. pag. Print.