Influence of heat treatment on spray-dried mixtures of Amioca (R) starch and Carbopol (R) 974P used as carriers for nasal drug delivery
- Author
- Delphine Coucke (UGent) , Eveline Pringels, P Foreman, P Adriaensens, R Carleer, Jean Paul Remon (UGent) and Chris Vervaet (UGent)
- Organization
- Abstract
- A mucoadhesive spray-dried starch/poly(acrylic acid) powder underwent different heat treatments in order to induce cross-linking between the functional groups of starch (Amioca (R)) and poly(acrylic acid) (Carbopol (R) 974P). After heat treatment the water-absorbing capacity, viscosity and elasticity of the mucoadhesive powder increased. NMR analysis in combination with FT-IR indicated that heat treatment induced a low degree of cross-linking between the polymers. Nasal administration of Amioca (R)/Carbopol (R) 974P powders without heat treatment resulted in an absolute bioavailability in rabbits of 8.2 +/- 3.0% for insulin. Due to the difference in water-absorbing capacity (which opened the tight junctions of the nasal mucosa), elasticity and plasticity (which reduced mucociliairy clearance and prolonged residence time) heat treatment at 120 degrees C improved the bioavailability: 26.4 +/- 21.9, 36.5 +/- 11.0 and 19.3 +/- 17.3% after heat treatment during 30 min, 1 h and 4 h, respectively. Heat treatment at 60 degrees C was less efficient. This study demonstrated that the nasal insulin absorption improved via heat treatment of the Amioca (R)/Carbopol (R) 974P powder (prior to the addition of insulin). The bioavailability-enhancing effect of a 1 h heat treatment at 120 degrees C was confirmed using the same polymer matrix in combination with different drugs (salmon calcitonin, human growth hormone and metoprolol tartrate). (C) 2009 Elsevier B.V. All rights reserved.
- Keywords
- Amioca (R)/Carbopol (R) 974P powder formulation, NMR spectroscopy, Heat treatment, ABSORPTION, INSULIN, MICROSPHERES, Insulin, Nasal delivery, SYSTEM
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-740862
- MLA
- Coucke, Delphine, et al. “Influence of Heat Treatment on Spray-Dried Mixtures of Amioca (R) Starch and Carbopol (R) 974P Used as Carriers for Nasal Drug Delivery.” INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 378, no. 1–2, 2009, pp. 45–50, doi:10.1016/j.ijpharm.2009.05.041.
- APA
- Coucke, D., Pringels, E., Foreman, P., Adriaensens, P., Carleer, R., Remon, J. P., & Vervaet, C. (2009). Influence of heat treatment on spray-dried mixtures of Amioca (R) starch and Carbopol (R) 974P used as carriers for nasal drug delivery. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 378(1–2), 45–50. https://doi.org/10.1016/j.ijpharm.2009.05.041
- Chicago author-date
- Coucke, Delphine, Eveline Pringels, P Foreman, P Adriaensens, R Carleer, Jean Paul Remon, and Chris Vervaet. 2009. “Influence of Heat Treatment on Spray-Dried Mixtures of Amioca (R) Starch and Carbopol (R) 974P Used as Carriers for Nasal Drug Delivery.” INTERNATIONAL JOURNAL OF PHARMACEUTICS 378 (1–2): 45–50. https://doi.org/10.1016/j.ijpharm.2009.05.041.
- Chicago author-date (all authors)
- Coucke, Delphine, Eveline Pringels, P Foreman, P Adriaensens, R Carleer, Jean Paul Remon, and Chris Vervaet. 2009. “Influence of Heat Treatment on Spray-Dried Mixtures of Amioca (R) Starch and Carbopol (R) 974P Used as Carriers for Nasal Drug Delivery.” INTERNATIONAL JOURNAL OF PHARMACEUTICS 378 (1–2): 45–50. doi:10.1016/j.ijpharm.2009.05.041.
- Vancouver
- 1.Coucke D, Pringels E, Foreman P, Adriaensens P, Carleer R, Remon JP, et al. Influence of heat treatment on spray-dried mixtures of Amioca (R) starch and Carbopol (R) 974P used as carriers for nasal drug delivery. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2009;378(1–2):45–50.
- IEEE
- [1]D. Coucke et al., “Influence of heat treatment on spray-dried mixtures of Amioca (R) starch and Carbopol (R) 974P used as carriers for nasal drug delivery,” INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 378, no. 1–2, pp. 45–50, 2009.
@article{740862, abstract = {{A mucoadhesive spray-dried starch/poly(acrylic acid) powder underwent different heat treatments in order to induce cross-linking between the functional groups of starch (Amioca (R)) and poly(acrylic acid) (Carbopol (R) 974P). After heat treatment the water-absorbing capacity, viscosity and elasticity of the mucoadhesive powder increased. NMR analysis in combination with FT-IR indicated that heat treatment induced a low degree of cross-linking between the polymers. Nasal administration of Amioca (R)/Carbopol (R) 974P powders without heat treatment resulted in an absolute bioavailability in rabbits of 8.2 +/- 3.0% for insulin. Due to the difference in water-absorbing capacity (which opened the tight junctions of the nasal mucosa), elasticity and plasticity (which reduced mucociliairy clearance and prolonged residence time) heat treatment at 120 degrees C improved the bioavailability: 26.4 +/- 21.9, 36.5 +/- 11.0 and 19.3 +/- 17.3% after heat treatment during 30 min, 1 h and 4 h, respectively. Heat treatment at 60 degrees C was less efficient. This study demonstrated that the nasal insulin absorption improved via heat treatment of the Amioca (R)/Carbopol (R) 974P powder (prior to the addition of insulin). The bioavailability-enhancing effect of a 1 h heat treatment at 120 degrees C was confirmed using the same polymer matrix in combination with different drugs (salmon calcitonin, human growth hormone and metoprolol tartrate). (C) 2009 Elsevier B.V. All rights reserved.}}, author = {{Coucke, Delphine and Pringels, Eveline and Foreman, P and Adriaensens, P and Carleer, R and Remon, Jean Paul and Vervaet, Chris}}, issn = {{0378-5173}}, journal = {{INTERNATIONAL JOURNAL OF PHARMACEUTICS}}, keywords = {{Amioca (R)/Carbopol (R) 974P powder formulation,NMR spectroscopy,Heat treatment,ABSORPTION,INSULIN,MICROSPHERES,Insulin,Nasal delivery,SYSTEM}}, language = {{eng}}, number = {{1-2}}, pages = {{45--50}}, title = {{Influence of heat treatment on spray-dried mixtures of Amioca (R) starch and Carbopol (R) 974P used as carriers for nasal drug delivery}}, url = {{http://doi.org/10.1016/j.ijpharm.2009.05.041}}, volume = {{378}}, year = {{2009}}, }
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