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Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium

Tim Erkens UGent, Sylvie Daminet UGent, Carolien Rogiers UGent, Kris Gommeren UGent, Evelyne Lampo UGent, Dominique Vander Donckt UGent, Alice Van den Broeke UGent, Mario Van Poucke UGent, Alex Van Zeveren UGent and Luc Peelman UGent (2009) VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 78(4). p.256-260
abstract
Hypersensitivity to ivermectin and certain other drugs in Collies and related breeds is caused by a 4-base pair deletion mutation in the ABCB1 gene, better known as the MDR1 gene, encoding P-glycoprotein. There is no information available, however, regarding the presence of this mutation in dogs in Belgium. In this study, the ABCB1 genotype was assessed in 92 dogs of breeds suspected to possess the deletion mutation. The results indicated that the mutation was present in the Australian Shepherd, Collie, Shetland Sheepdog and Swiss White Shepherd, but was not detected in the Bearded Collies, Border Collies and German Shepherds of this study, which is in accordance with the findings in similar breed populations of other countries. In Belgium it is therefore important to take the ABCB1 genotype of the breeds involved into account, in order to use drugs in a safe and efficient manner and to improve the selection procedure in dog breeding.
Please use this url to cite or link to this publication:
author
organization
alternative title
Aanwezigheid van de ABCB1 (MDR1) deletiemutatie verantwoordelijk voor ivermectine overgevoeligheid bij enkele hondenrassen in België
year
type
journalArticle (original)
publication status
published
subject
journal title
VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
Vlaams Diergeneesk. Tijds.
volume
78
issue
4
pages
256 - 260
Web of Science type
Article
Web of Science id
000269791700002
JCR category
VETERINARY SCIENCES
JCR impact factor
0.179 (2009)
JCR rank
118/141 (2009)
JCR quartile
4 (2009)
ISSN
0303-9021
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
740545
handle
http://hdl.handle.net/1854/LU-740545
alternative location
http://vdt.ugent.be/code/showupload.php?id=488
date created
2009-09-03 09:36:01
date last changed
2009-11-20 15:34:22
@article{740545,
  abstract     = {Hypersensitivity to ivermectin and certain other drugs in Collies and related breeds is caused by a 4-base pair deletion mutation in the ABCB1 gene, better known as the MDR1 gene, encoding P-glycoprotein. There is no information available, however, regarding the presence of this mutation in dogs in Belgium. In this study, the ABCB1 genotype was assessed in 92 dogs of breeds suspected to possess the deletion mutation. The results indicated that the mutation was present in the Australian Shepherd, Collie, Shetland Sheepdog and Swiss White Shepherd, but was not detected in the Bearded Collies, Border Collies and German Shepherds of this study, which is in accordance with the findings in similar breed populations of other countries. In Belgium it is therefore important to take the ABCB1 genotype of the breeds involved into account, in order to use drugs in a safe and efficient manner and to improve the selection procedure in dog breeding.},
  author       = {Erkens, Tim and Daminet, Sylvie and Rogiers, Carolien and Gommeren, Kris and Lampo, Evelyne and Vander Donckt, Dominique and Van den Broeke, Alice and Van Poucke, Mario and Van Zeveren, Alex and Peelman, Luc},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  language     = {eng},
  number       = {4},
  pages        = {256--260},
  title        = {Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium},
  url          = {http://vdt.ugent.be/code/showupload.php?id=488},
  volume       = {78},
  year         = {2009},
}

Chicago
Erkens, Tim, Sylvie Daminet, Carolien Rogiers, Kris Gommeren, Evelyne Lampo, Dominique Vander Donckt, Alice Van den Broeke, Mario Van Poucke, Alex Van Zeveren, and Luc Peelman. 2009. “Presence of the ABCB1 (MDR1) Deletion Mutation Causing Ivermectin Hypersensitivity in Certain Dog Breeds in Belgium.” Vlaams Diergeneeskundig Tijdschrift 78 (4): 256–260.
APA
Erkens, T., Daminet, S., Rogiers, C., Gommeren, K., Lampo, E., Vander Donckt, D., Van den Broeke, A., et al. (2009). Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 78(4), 256–260.
Vancouver
1.
Erkens T, Daminet S, Rogiers C, Gommeren K, Lampo E, Vander Donckt D, et al. Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2009;78(4):256–60.
MLA
Erkens, Tim, Sylvie Daminet, Carolien Rogiers, et al. “Presence of the ABCB1 (MDR1) Deletion Mutation Causing Ivermectin Hypersensitivity in Certain Dog Breeds in Belgium.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 78.4 (2009): 256–260. Print.