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The paradox of scored tablets: a cost-saving risk

Bart De Spiegeleer UGent, Lindsay Van Hoorebeke, Anton De Spiegeleer UGent, Pieter Castelein and Lucas Van Bortel (2009) Pharmazie. 64(8). p.550-552
abstract
One of the cornerstones of pharmacotherapy is the proper dose of medicine, which should ideally be tailored to the individual patient. However, even if clinically possible, this is economically not feasible as a too large number of different dosage strengths would be required. Therefore, a balance is required between the patient's benefit/risk and the cost to the individual and society on the other hand. Scored or splitted tablets were, and still are, often used strategies to these opposite interests, enabling more dose-flexibility, but also at the same time increasing the dose-variability as a consequence of the breaking process. The question of how to deal with this paradox was investigated by exploring the prevalence and classification of scored tablets as well as the cost-benefits. A strategy for clinical pharmacologists is presented to improve the outcome of this paradox.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
breakability, dose-variability, scored tablets
journal title
Pharmazie
Pharmazie
volume
64
issue
8
pages
550 - 552
Web of Science type
Article
Web of Science id
000268994100014
JCR category
CHEMISTRY, MULTIDISCIPLINARY
JCR impact factor
0.812 (2009)
JCR rank
88/137 (2009)
JCR quartile
3 (2009)
ISSN
0031-7144
DOI
10.1691/ph.2009.9532
language
English
UGent publication?
yes
classification
A1
id
740092
handle
http://hdl.handle.net/1854/LU-740092
date created
2009-09-01 19:59:21
date last changed
2016-12-19 15:46:37
@article{740092,
  abstract     = {One of the cornerstones of pharmacotherapy is the proper dose of medicine, which should ideally be tailored to the individual patient. However, even if clinically possible, this is economically not feasible as a too large number of different dosage strengths would be required. Therefore, a balance is required between the patient's benefit/risk and the cost to the individual and society on the other hand. Scored or splitted tablets were, and still are, often used strategies to these opposite interests, enabling more dose-flexibility, but also at the same time increasing the dose-variability as a consequence of the breaking process. The question of how to deal with this paradox was investigated by exploring the prevalence and classification of scored tablets as well as the cost-benefits. A strategy for clinical pharmacologists is presented to improve the outcome of this paradox.},
  author       = {De Spiegeleer, Bart and Van Hoorebeke, Lindsay and De Spiegeleer, Anton and Castelein, Pieter and Van Bortel, Lucas},
  issn         = {0031-7144},
  journal      = {Pharmazie},
  keyword      = {breakability,dose-variability,scored tablets},
  language     = {eng},
  number       = {8},
  pages        = {550--552},
  title        = {The paradox of scored tablets: a cost-saving risk},
  url          = {http://dx.doi.org/10.1691/ph.2009.9532},
  volume       = {64},
  year         = {2009},
}

Chicago
De Spiegeleer, Bart, Lindsay Van Hoorebeke, Anton De Spiegeleer, Pieter Castelein, and Lucas Van Bortel. 2009. “The Paradox of Scored Tablets: a Cost-saving Risk.” Pharmazie 64 (8): 550–552.
APA
De Spiegeleer, B., Van Hoorebeke, L., De Spiegeleer, A., Castelein, P., & Van Bortel, L. (2009). The paradox of scored tablets: a cost-saving risk. Pharmazie, 64(8), 550–552.
Vancouver
1.
De Spiegeleer B, Van Hoorebeke L, De Spiegeleer A, Castelein P, Van Bortel L. The paradox of scored tablets: a cost-saving risk. Pharmazie. 2009;64(8):550–2.
MLA
De Spiegeleer, Bart, Lindsay Van Hoorebeke, Anton De Spiegeleer, et al. “The Paradox of Scored Tablets: a Cost-saving Risk.” Pharmazie 64.8 (2009): 550–552. Print.