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The paradox of scored tablets: a cost-saving risk

(2009) Pharmazie. 64(8). p.550-552
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Abstract
One of the cornerstones of pharmacotherapy is the proper dose of medicine, which should ideally be tailored to the individual patient. However, even if clinically possible, this is economically not feasible as a too large number of different dosage strengths would be required. Therefore, a balance is required between the patient's benefit/risk and the cost to the individual and society on the other hand. Scored or splitted tablets were, and still are, often used strategies to these opposite interests, enabling more dose-flexibility, but also at the same time increasing the dose-variability as a consequence of the breaking process. The question of how to deal with this paradox was investigated by exploring the prevalence and classification of scored tablets as well as the cost-benefits. A strategy for clinical pharmacologists is presented to improve the outcome of this paradox.
Keywords
breakability, dose-variability, scored tablets

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Citation

Please use this url to cite or link to this publication:

Chicago
De Spiegeleer, Bart, Lindsay Van Hoorebeke, Anton De Spiegeleer, Pieter Castelein, and Lucas Van Bortel. 2009. “The Paradox of Scored Tablets: a Cost-saving Risk.” Pharmazie 64 (8): 550–552.
APA
De Spiegeleer, B., Van Hoorebeke, L., De Spiegeleer, A., Castelein, P., & Van Bortel, L. (2009). The paradox of scored tablets: a cost-saving risk. Pharmazie, 64(8), 550–552.
Vancouver
1.
De Spiegeleer B, Van Hoorebeke L, De Spiegeleer A, Castelein P, Van Bortel L. The paradox of scored tablets: a cost-saving risk. Pharmazie. 2009;64(8):550–2.
MLA
De Spiegeleer, Bart, Lindsay Van Hoorebeke, Anton De Spiegeleer, et al. “The Paradox of Scored Tablets: a Cost-saving Risk.” Pharmazie 64.8 (2009): 550–552. Print.
@article{740092,
  abstract     = {One of the cornerstones of pharmacotherapy is the proper dose of medicine, which should ideally be tailored to the individual patient. However, even if clinically possible, this is economically not feasible as a too large number of different dosage strengths would be required. Therefore, a balance is required between the patient's benefit/risk and the cost to the individual and society on the other hand. Scored or splitted tablets were, and still are, often used strategies to these opposite interests, enabling more dose-flexibility, but also at the same time increasing the dose-variability as a consequence of the breaking process. The question of how to deal with this paradox was investigated by exploring the prevalence and classification of scored tablets as well as the cost-benefits. A strategy for clinical pharmacologists is presented to improve the outcome of this paradox.},
  author       = {De Spiegeleer, Bart and Van Hoorebeke, Lindsay and De Spiegeleer, Anton and Castelein, Pieter and Van Bortel, Lucas},
  issn         = {0031-7144},
  journal      = {Pharmazie},
  keyword      = {breakability,dose-variability,scored tablets},
  language     = {eng},
  number       = {8},
  pages        = {550--552},
  title        = {The paradox of scored tablets: a cost-saving risk},
  url          = {http://dx.doi.org/10.1691/ph.2009.9532},
  volume       = {64},
  year         = {2009},
}

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