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The pros and cons of polyelectrolyte capsules in drug delivery

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Abstract
Polyelectrolyte multilayer microcapsules and nanocapsules are under review as multifunctional delivery systems. Tailoring functions in the entity of a single capsule is done by incorporation of functional polyelectrolytes or nanoparticles in between the layers during electrostatic self-assembly. The resulting capsules possess different properties such as controlled and triggered release, responsiveness to temperature, pH and light and could be navigated with a magnetic field. A variety of substances can be encapsulated and delivered to cells and tissues. Potential applications as well as in vivo experiments have recently been explored. Capsules made of biodegradable polymers showed low toxicity in vivo. Perspectives on and obstacles to a way of broader application are discussed.
Keywords
CONSECUTIVELY ALTERNATING ADSORPTION, CATIONIC BIPOLAR AMPHIPHILES, SELF-ASSEMBLY PROCESS, MESOPOROUS SILICA SPHERES, ULTRATHIN MULTILAYER FILMS, nanoparticles, layer-by-layer, encapsulation, colloids, controlled release, THIN-FILMS, POLYMER MICROCAPSULES, COLLOIDAL PARTICLES, RELEASE PROPERTIES, CHARGED SURFACES

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Citation

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MLA
De Geest, Bruno, et al. “The Pros and Cons of Polyelectrolyte Capsules in Drug Delivery.” Expert Opinion on Drug Delivery, vol. 6, no. 6, 2009, pp. 613–24, doi:10.1517/174252409029800162.
APA
De Geest, B., Sukhorukov, G., & Mohwald, H. (2009). The pros and cons of polyelectrolyte capsules in drug delivery. Expert Opinion on Drug Delivery, 6(6), 613–624. https://doi.org/10.1517/174252409029800162
Chicago author-date
De Geest, Bruno, GB Sukhorukov, and H Mohwald. 2009. “The Pros and Cons of Polyelectrolyte Capsules in Drug Delivery.” Expert Opinion on Drug Delivery 6 (6): 613–24. https://doi.org/10.1517/174252409029800162.
Chicago author-date (all authors)
De Geest, Bruno, GB Sukhorukov, and H Mohwald. 2009. “The Pros and Cons of Polyelectrolyte Capsules in Drug Delivery.” Expert Opinion on Drug Delivery 6 (6): 613–624. doi:10.1517/174252409029800162.
Vancouver
1.
De Geest B, Sukhorukov G, Mohwald H. The pros and cons of polyelectrolyte capsules in drug delivery. Expert opinion on drug delivery. 2009;6(6):613–24.
IEEE
[1]
B. De Geest, G. Sukhorukov, and H. Mohwald, “The pros and cons of polyelectrolyte capsules in drug delivery,” Expert opinion on drug delivery, vol. 6, no. 6, pp. 613–624, 2009.
@article{731114,
  abstract     = {{Polyelectrolyte multilayer microcapsules and nanocapsules are under review as multifunctional delivery systems. Tailoring functions in the entity of a single capsule is done by incorporation of functional polyelectrolytes or nanoparticles in between the layers during electrostatic self-assembly. The resulting capsules possess different properties such as controlled and triggered release, responsiveness to temperature, pH and light and could be navigated with a magnetic field. A variety of substances can be encapsulated and delivered to cells and tissues. Potential applications as well as in vivo experiments have recently been explored. Capsules made of biodegradable polymers showed low toxicity in vivo. Perspectives on and obstacles to a way of broader application are discussed.}},
  author       = {{De Geest, Bruno and Sukhorukov, GB and Mohwald, H}},
  issn         = {{1742-5247}},
  journal      = {{Expert opinion on drug delivery}},
  keywords     = {{CONSECUTIVELY ALTERNATING ADSORPTION,CATIONIC BIPOLAR AMPHIPHILES,SELF-ASSEMBLY PROCESS,MESOPOROUS SILICA SPHERES,ULTRATHIN MULTILAYER FILMS,nanoparticles,layer-by-layer,encapsulation,colloids,controlled release,THIN-FILMS,POLYMER MICROCAPSULES,COLLOIDAL PARTICLES,RELEASE PROPERTIES,CHARGED SURFACES}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{613--624}},
  title        = {{The pros and cons of polyelectrolyte capsules in drug delivery}},
  url          = {{http://dx.doi.org/10.1517/174252409029800162}},
  volume       = {{6}},
  year         = {{2009}},
}

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