Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance
- Author
- Simon Devos (UGent) , Stephan Stremersch (UGent) , Koen Raemdonck (UGent) , Kevin Braeckmans (UGent) and Bart Devreese (UGent)
- Organization
- Abstract
- The treatment of Stenotrophomonas maltophilia infection with beta-lactam antibiotics leads to increased release of outer membrane vesicles (OMVs), which are packed with two chromosomally encoded beta-lactamases. Here, we show that these beta-lactamase-packed OMVs are capable of establishing extracellular beta-lactam degradation. We also show that they dramatically increase the apparent MICs of imipenem and ticarcillin for the cohabituating species Pseudomonas aeruginosa and Burkholderia cenocepacia.
- Keywords
- IMIPENEM, PATHOGEN
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-7280708
- MLA
- Devos, Simon, et al. “Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas Maltophilia on β-Lactam Resistance.” ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 60, no. 4, 2016, pp. 2516–18, doi:10.1128/AAC.02171-15.
- APA
- Devos, S., Stremersch, S., Raemdonck, K., Braeckmans, K., & Devreese, B. (2016). Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(4), 2516–2518. https://doi.org/10.1128/AAC.02171-15
- Chicago author-date
- Devos, Simon, Stephan Stremersch, Koen Raemdonck, Kevin Braeckmans, and Bart Devreese. 2016. “Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas Maltophilia on β-Lactam Resistance.” ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 60 (4): 2516–18. https://doi.org/10.1128/AAC.02171-15.
- Chicago author-date (all authors)
- Devos, Simon, Stephan Stremersch, Koen Raemdonck, Kevin Braeckmans, and Bart Devreese. 2016. “Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas Maltophilia on β-Lactam Resistance.” ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 60 (4): 2516–2518. doi:10.1128/AAC.02171-15.
- Vancouver
- 1.Devos S, Stremersch S, Raemdonck K, Braeckmans K, Devreese B. Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2016;60(4):2516–8.
- IEEE
- [1]S. Devos, S. Stremersch, K. Raemdonck, K. Braeckmans, and B. Devreese, “Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance,” ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 60, no. 4, pp. 2516–2518, 2016.
@article{7280708, abstract = {{The treatment of Stenotrophomonas maltophilia infection with beta-lactam antibiotics leads to increased release of outer membrane vesicles (OMVs), which are packed with two chromosomally encoded beta-lactamases. Here, we show that these beta-lactamase-packed OMVs are capable of establishing extracellular beta-lactam degradation. We also show that they dramatically increase the apparent MICs of imipenem and ticarcillin for the cohabituating species Pseudomonas aeruginosa and Burkholderia cenocepacia.}}, author = {{Devos, Simon and Stremersch, Stephan and Raemdonck, Koen and Braeckmans, Kevin and Devreese, Bart}}, issn = {{0066-4804}}, journal = {{ANTIMICROBIAL AGENTS AND CHEMOTHERAPY}}, keywords = {{IMIPENEM,PATHOGEN}}, language = {{eng}}, number = {{4}}, pages = {{2516--2518}}, title = {{Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance}}, url = {{http://doi.org/10.1128/AAC.02171-15}}, volume = {{60}}, year = {{2016}}, }
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