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Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance

Simon Devos (UGent) , Stephan Stremersch (UGent) , Koen Raemdonck (UGent) , Kevin Braeckmans (UGent) and Bart Devreese (UGent)
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Abstract
The treatment of Stenotrophomonas maltophilia infection with beta-lactam antibiotics leads to increased release of outer membrane vesicles (OMVs), which are packed with two chromosomally encoded beta-lactamases. Here, we show that these beta-lactamase-packed OMVs are capable of establishing extracellular beta-lactam degradation. We also show that they dramatically increase the apparent MICs of imipenem and ticarcillin for the cohabituating species Pseudomonas aeruginosa and Burkholderia cenocepacia.
Keywords
IMIPENEM, PATHOGEN

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Citation

Please use this url to cite or link to this publication:

Chicago
Devos, Simon, Stephan Stremersch, Koen Raemdonck, Kevin Braeckmans, and Bart Devreese. 2016. “Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas Maltophilia on Β-lactam Resistance.” Antimicrobial Agents and Chemotherapy 60 (4): 2516–2518.
APA
Devos, Simon, Stremersch, S., Raemdonck, K., Braeckmans, K., & Devreese, B. (2016). Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(4), 2516–2518.
Vancouver
1.
Devos S, Stremersch S, Raemdonck K, Braeckmans K, Devreese B. Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2016;60(4):2516–8.
MLA
Devos, Simon, Stephan Stremersch, Koen Raemdonck, et al. “Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas Maltophilia on Β-lactam Resistance.” ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 60.4 (2016): 2516–2518. Print.
@article{7280708,
  abstract     = {The treatment of Stenotrophomonas maltophilia infection with beta-lactam antibiotics leads to increased release of outer membrane vesicles (OMVs), which are packed with two chromosomally encoded beta-lactamases. Here, we show that these beta-lactamase-packed OMVs are capable of establishing extracellular beta-lactam degradation. We also show that they dramatically increase the apparent MICs of imipenem and ticarcillin for the cohabituating species Pseudomonas aeruginosa and Burkholderia cenocepacia.},
  author       = {Devos, Simon and Stremersch, Stephan and Raemdonck, Koen and Braeckmans, Kevin and Devreese, Bart},
  issn         = {0066-4804},
  journal      = {ANTIMICROBIAL AGENTS AND CHEMOTHERAPY},
  language     = {eng},
  number       = {4},
  pages        = {2516--2518},
  title        = {Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on \ensuremath{\beta}-lactam resistance},
  url          = {http://dx.doi.org/10.1128/AAC.02171-15},
  volume       = {60},
  year         = {2016},
}

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