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Paediatric Crohn's disease : disease activity and growth in the BELCRO cohort after 3 years follow-up

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Abstract
Objective: The Belgian registry for paediatric Crohn disease (BELCRO) cohort is a prospective, multicentre registry for newly diagnosed paediatric patients with Crohn disease (CD) (<18 years) recruited from 2008 to 2010 to identify predictive factors for disease activity and growth. Methods: Data from the BELCRO database were evaluated at diagnosis, 24 and 36 months follow-up. Results: At month 36 (M36), data were available on 84 of the 98 patients included at diagnosis. Disease activity evolved as follows: inactive 5% to 70%, mild 19% to 24%, and moderate to severe 76% to 6%. None of the variables such as age, sex, diagnostic delay, type of treatment, disease location, disease activity at diagnosis, and growth were associated with disease activity at M36. Paediatricians studied significantly less patients with active disease at M36 compared with adult physicians. Sixty percent of the patients had biologicals as part of their treatment at M36. Adult gastroenterologists initiated biologicals significantly earlier. They were the only factor determining biologicals' initiation, not disease location or disease severity at diagnosis. Median body mass index (BMI) z score evolved from -0.97 (range -5.5-2.1) to 0.11 (range -3.4-2) and median height z score from -0.15 (range -3.4-1.6) to 0.12 (range -2.3-2.3) at M36. None of the variables mentioned above influenced growth over time. Conclusions: Present treatment strategies lead to good disease control in the BELCRO cohort after 3 years. Logistic regression analysis did not show any influence of disease location or present treatment strategy on disease activity and growth, but patients under paediatric care had significantly less severe disease at M36.
Keywords
Crohn's disease, Inflammatory bowel disease, children, Growth, Disease severity, registry, Paediatric, INFLAMMATORY-BOWEL-DISEASE, POPULATION-BASED COHORT, NUTRITIONAL-STATUS, CHILDREN, DIAGNOSIS, REGISTRY, INFLIXIMAB, OUTCOMES

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Citation

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Chicago
De Greef, Elisabeth, Ilse Hoffman, Françoise Smets, Stephanie Van Biervliet, Patrick Bontems, Bruno Hauser, Isabelle Paquot, et al. 2016. “Paediatric Crohn’s Disease : Disease Activity and Growth in the BELCRO Cohort After 3 Years Follow-up.” Journal of Pediatric Gastroenterology and Nutrition 63 (2): 253–258.
APA
De Greef, Elisabeth, Hoffman, I., Smets, F., Van Biervliet, S., Bontems, P., Hauser, B., Paquot, I., et al. (2016). Paediatric Crohn’s disease : disease activity and growth in the BELCRO cohort after 3 years follow-up. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 63(2), 253–258.
Vancouver
1.
De Greef E, Hoffman I, Smets F, Van Biervliet S, Bontems P, Hauser B, et al. Paediatric Crohn’s disease : disease activity and growth in the BELCRO cohort after 3 years follow-up. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 2016;63(2):253–8.
MLA
De Greef, Elisabeth, Ilse Hoffman, Françoise Smets, et al. “Paediatric Crohn’s Disease : Disease Activity and Growth in the BELCRO Cohort After 3 Years Follow-up.” JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 63.2 (2016): 253–258. Print.
@article{7280121,
  abstract     = {Objective: The Belgian registry for paediatric Crohn disease (BELCRO) cohort is a prospective, multicentre registry for newly diagnosed paediatric patients with Crohn disease (CD) ({\textlangle}18 years) recruited from 2008 to 2010 to identify predictive factors for disease activity and growth. 
Methods: Data from the BELCRO database were evaluated at diagnosis, 24 and 36 months follow-up. 
Results: At month 36 (M36), data were available on 84 of the 98 patients included at diagnosis. Disease activity evolved as follows: inactive 5\% to 70\%, mild 19\% to 24\%, and moderate to severe 76\% to 6\%. None of the variables such as age, sex, diagnostic delay, type of treatment, disease location, disease activity at diagnosis, and growth were associated with disease activity at M36. Paediatricians studied significantly less patients with active disease at M36 compared with adult physicians. Sixty percent of the patients had biologicals as part of their treatment at M36. Adult gastroenterologists initiated biologicals significantly earlier. They were the only factor determining biologicals' initiation, not disease location or disease severity at diagnosis. Median body mass index (BMI) z score evolved from -0.97 (range -5.5-2.1) to 0.11 (range -3.4-2) and median height z score from -0.15 (range -3.4-1.6) to 0.12 (range -2.3-2.3) at M36. None of the variables mentioned above influenced growth over time. 
Conclusions: Present treatment strategies lead to good disease control in the BELCRO cohort after 3 years. Logistic regression analysis did not show any influence of disease location or present treatment strategy on disease activity and growth, but patients under paediatric care had significantly less severe disease at M36.},
  author       = { De Greef, Elisabeth and Hoffman, Ilse and Smets, Fran\c{c}oise and Van Biervliet, Stephanie and Bontems, Patrick and Hauser, Bruno and Paquot, Isabelle and Alliet, Philippe and Arts, Wim and Dewit, Olivier and De Vos, Martine and Baert, Filip and Bossuyt, Peter and Rahier, Jean-Fran\c{c}ois and Franchimont, Denis and Vermeire, Severine and Fontaine, Fernand and Louis, Edouard and Coche, JC and Veereman, Gigi},
  issn         = {0277-2116},
  journal      = {JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION},
  keyword      = {Crohn's disease,Inflammatory bowel disease,children,Growth,Disease severity,registry,Paediatric,INFLAMMATORY-BOWEL-DISEASE,POPULATION-BASED COHORT,NUTRITIONAL-STATUS,CHILDREN,DIAGNOSIS,REGISTRY,INFLIXIMAB,OUTCOMES},
  language     = {eng},
  number       = {2},
  pages        = {253--258},
  title        = {Paediatric Crohn's disease : disease activity and growth in the BELCRO cohort after 3 years follow-up},
  url          = {http://dx.doi.org/10.1097/MPG.0000000000001132},
  volume       = {63},
  year         = {2016},
}

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