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Hearing in children with congenital cytomegalovirus infection: results of a longitudinal study

(2016) JOURNAL OF PEDIATRICS. 172. p.110-115
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Abstract
Objectives: To evaluate hearing outcome, to characterize the nature of symptomatic and asymptomatic congenital cytomegalovirus (cCMV) infection and associated hearing loss, and to compare results with data from previous studies. Study design: A prospective multicenter registry was set up in 2007. Six centers participated in the development of a standardized protocol for diagnosis, treatment, and follow-up. Data were gathered in an online registry. Children (n = 379) with a documented cCMV infection and at least 2 separate audiologic evaluations were included. Audiometric results from a multicenter cohort study of children with cCMV infection with longitudinal observation were examined. Results: Results from 123 children with a symptomatic and 256 children with an asymptomatic cCMV infection were analyzed. In the group with symptomatic cCMV, 63% had hearing loss, compared with 8% in the group with asymptomatic cCMV. Delayed-onset hearing loss occurred in 10.6% of symptomatic cCMV and in 7.8% of asymptomatic cCMV. In the group with symptomatic cCMV, 29.3% of children used some kind of hearing amplification; 1.6% in the group with asymptomatic cCMV used hearing amplification. Conclusions: Symptomatic and asymptomatic cCMV infections are a major cause of hearing loss in childhood. Reliable estimates of the long-term outcome of cCMV infection are mandatory to increase vigilance, especially among pregnant women and to draw attention to preventive measures, vaccine development, and prenatal and postnatal therapy. Universal screening of newborns for cCMV infection should be initiated and combined with longitudinal audiometric follow-up.
Keywords
METAANALYSIS, CMV INFECTION, THRESHOLDS, PREVALENCE, MANAGEMENT, MORTALITY, SEQUELAE

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Chicago
GODERIS, JULIE, ANNELIES KEYMEULEN, Koenraad Smets, Helen Van Hoecke, Els De Leenheer, An Boudewyns, Christian Desloovere, et al. 2016. “Hearing in Children with Congenital Cytomegalovirus Infection: Results of a Longitudinal Study.” Journal of Pediatrics 172: 110–115.
APA
GODERIS, J., KEYMEULEN, A., Smets, K., Van Hoecke, H., De Leenheer, E., Boudewyns, A., Desloovere, C., et al. (2016). Hearing in children with congenital cytomegalovirus infection: results of a longitudinal study. JOURNAL OF PEDIATRICS, 172, 110–115.
Vancouver
1.
GODERIS J, KEYMEULEN A, Smets K, Van Hoecke H, De Leenheer E, Boudewyns A, et al. Hearing in children with congenital cytomegalovirus infection: results of a longitudinal study. JOURNAL OF PEDIATRICS. 2016;172:110–5.
MLA
GODERIS, JULIE, ANNELIES KEYMEULEN, Koenraad Smets, et al. “Hearing in Children with Congenital Cytomegalovirus Infection: Results of a Longitudinal Study.” JOURNAL OF PEDIATRICS 172 (2016): 110–115. Print.
@article{7279407,
  abstract     = {Objectives: To evaluate hearing outcome, to characterize the nature of symptomatic and asymptomatic congenital cytomegalovirus (cCMV) infection and associated hearing loss, and to compare results with data from previous studies. 
Study design: A prospective multicenter registry was set up in 2007. Six centers participated in the development of a standardized protocol for diagnosis, treatment, and follow-up. Data were gathered in an online registry. Children (n = 379) with a documented cCMV infection and at least 2 separate audiologic evaluations were included. Audiometric results from a multicenter cohort study of children with cCMV infection with longitudinal observation were examined. 
Results: Results from 123 children with a symptomatic and 256 children with an asymptomatic cCMV infection were analyzed. In the group with symptomatic cCMV, 63\% had hearing loss, compared with 8\% in the group with asymptomatic cCMV. Delayed-onset hearing loss occurred in 10.6\% of symptomatic cCMV and in 7.8\% of asymptomatic cCMV. In the group with symptomatic cCMV, 29.3\% of children used some kind of hearing amplification; 1.6\% in the group with asymptomatic cCMV used hearing amplification. 
Conclusions: Symptomatic and asymptomatic cCMV infections are a major cause of hearing loss in childhood. Reliable estimates of the long-term outcome of cCMV infection are mandatory to increase vigilance, especially among pregnant women and to draw attention to preventive measures, vaccine development, and prenatal and postnatal therapy. Universal screening of newborns for cCMV infection should be initiated and combined with longitudinal audiometric follow-up.},
  author       = {GODERIS, JULIE and Keymeulen, Annelies and Smets, Koenraad and Van Hoecke, Helen and De Leenheer, Els and Boudewyns, An and Desloovere, Christian and Kuhweide, Rudolf and Muylle, Marie and Royackers, Liesbeth and Schatteman, Isabelle and Dhooge, Ingeborg},
  issn         = {0022-3476},
  journal      = {JOURNAL OF PEDIATRICS},
  keyword      = {METAANALYSIS,CMV INFECTION,THRESHOLDS,PREVALENCE,MANAGEMENT,MORTALITY,SEQUELAE},
  language     = {eng},
  pages        = {110--115},
  title        = {Hearing in children with congenital cytomegalovirus infection: results of a longitudinal study},
  url          = {http://dx.doi.org/10.1016/j.jpeds.2016.01.024},
  volume       = {172},
  year         = {2016},
}

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