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Variation in hemolytic activity of Brachyspira hyodysenteriae strains from pigs

Maxime Mahu (UGent) , Nele De Pauw, Lien Vande Maele (UGent) , Marc Verlinden (UGent) , Filip Boyen (UGent) , Richard Ducatelle (UGent) , Freddy Haesebrouck (UGent) , An Martel (UGent) and Frank Pasmans (UGent)
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Abstract
Brachyspira hyodysenteriae is the primary cause of swine dysentery, which is responsible for major economic losses to the pig industry worldwide. The hemolytic activity of 10 B. hyodysenteriae strains isolated from stools of pigs with mild to mucohemorrhagic diarrhea was compared and seven hemolysis associated genes were sequenced. Hemolysis induced by these strains varied from strong to near absent. One weakly hemolytic B. hyodysenteriae strain showed sequence changes in five hemolysis associated genes (tlyA, tlyB, hemolysin III, hemolysin activation protein and hemolysin III channel protein) resulting in amino acid substitutions. The occurrence of weakly hemolytic strains identifiable as B. hyodysenteriae should be taken into account in swine dysentery diagnostics. The presence of these strains may affect herd dysentery status, with great impact on a farms trading opportunities.
Keywords
EXPRESSION, hemolysis, PILOSICOLI, VIRULENCE, GENE, LIFE-STYLE, MOLECULAR CHARACTERIZATION, MYCOBACTERIUM-TUBERCULOSIS, SWINE-DYSENTERY, SERPULINA-HYODYSENTERIAE, hemolysis associated genes, TREPONEMA-HYODYSENTERIAE, Brachyspira hyodysenteriae, swine dysentery

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Chicago
Mahu, Maxime, Nele De Pauw, Lien Vande Maele, Marc Verlinden, Filip Boyen, Richard Ducatelle, Freddy Haesebrouck, An Martel, and Frank Pasmans. 2016. “Variation in Hemolytic Activity of Brachyspira Hyodysenteriae Strains from Pigs.” Veterinary Research 47.
APA
Mahu, M., De Pauw, N., Vande Maele, L., Verlinden, M., Boyen, F., Ducatelle, R., Haesebrouck, F., et al. (2016). Variation in hemolytic activity of Brachyspira hyodysenteriae strains from pigs. VETERINARY RESEARCH, 47.
Vancouver
1.
Mahu M, De Pauw N, Vande Maele L, Verlinden M, Boyen F, Ducatelle R, et al. Variation in hemolytic activity of Brachyspira hyodysenteriae strains from pigs. VETERINARY RESEARCH. 2016;47.
MLA
Mahu, Maxime, Nele De Pauw, Lien Vande Maele, et al. “Variation in Hemolytic Activity of Brachyspira Hyodysenteriae Strains from Pigs.” VETERINARY RESEARCH 47 (2016): n. pag. Print.
@article{7279000,
  abstract     = {Brachyspira hyodysenteriae is the primary cause of swine dysentery, which is responsible for major economic losses to the pig industry worldwide. The hemolytic activity of 10 B. hyodysenteriae strains isolated from stools of pigs with mild to mucohemorrhagic diarrhea was compared and seven hemolysis associated genes were sequenced. Hemolysis induced by these strains varied from strong to near absent. One weakly hemolytic B. hyodysenteriae strain showed sequence changes in five hemolysis associated genes (tlyA, tlyB, hemolysin III, hemolysin activation protein and hemolysin III channel protein) resulting in amino acid substitutions. The occurrence of weakly hemolytic strains identifiable as B. hyodysenteriae should be taken into account in swine dysentery diagnostics. The presence of these strains may affect herd dysentery status, with great impact on a farms trading opportunities.},
  articleno    = {66},
  author       = {Mahu, Maxime and De Pauw, Nele and Vande Maele, Lien and Verlinden, Marc and Boyen, Filip and Ducatelle, Richard and Haesebrouck, Freddy and Martel, An and Pasmans, Frank},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  language     = {eng},
  pages        = {10},
  title        = {Variation in~hemolytic activity of~Brachyspira hyodysenteriae strains from~pigs},
  url          = {http://dx.doi.org/10.1186/s13567-016-0353-x},
  volume       = {47},
  year         = {2016},
}

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