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Effects of carnosine supplementation on glucose metabolism : pilot clinical trial

(2016) OBESITY. 24(5). p.1027-1034
Author
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Abstract
OBJECTIVE: Carnosine is a naturally present dipeptide in humans and an over-the counter food additive. Evidence from animal studies supports the role for carnosine in the prevention and treatment of diabetes and cardiovascular disease, yet there is limited human data. This study investigated whether carnosine supplementation in individuals with overweight or obesity improves diabetes and cardiovascular risk factors. METHODS: In a double-blind randomized pilot trial in nondiabetic individuals with overweight and obesity (age 43 ± 8 years; body mass index 31 ± 4 kg/m(2) ), 15 individuals were randomly assigned to 2 g carnosine daily and 15 individuals to placebo for 12 weeks. Insulin sensitivity and secretion, glucose tolerance (oral glucose tolerance test), blood pressure, plasma lipid profile, skeletal muscle ((1) H-MRS), and urinary carnosine levels were measured. RESULTS: Carnosine concentrations increased in urine after supplementation (P < 0.05). An increase in fasting insulin and insulin resistance was hampered in individuals receiving carnosine compared to placebo, and this remained significant after adjustment for age, sex, and change in body weight (P = 0.02, P = 0.04, respectively). Two-hour glucose and insulin were both lower after carnosine supplementation compared to placebo in individuals with impaired glucose tolerance (P < 0.05). CONCLUSIONS: These pilot intervention data suggest that carnosine supplementation may be an effective strategy for prevention of type 2 diabetes.
Keywords
INSULIN-RESISTANCE, LIFETIME RISK, DOUBLE-BLIND, DETOXIFICATION, HISTIDINE, DISEASE, TYPE-2, RATS, INDIVIDUALS, GLYCATION

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MLA
de Courten, Barbora et al. “Effects of Carnosine Supplementation on Glucose Metabolism : Pilot Clinical Trial.” OBESITY 24.5 (2016): 1027–1034. Print.
APA
de Courten, B., Jakubova, M., de Courten, M. P., Kukurova, I. J., Vallova, S., Krumpolec, P., Valkovic, L., et al. (2016). Effects of carnosine supplementation on glucose metabolism : pilot clinical trial. OBESITY, 24(5), 1027–1034.
Chicago author-date
de Courten, Barbora, Michaela Jakubova, Maximilian PJ de Courten, Ivica Just Kukurova, Silvia Vallova, Patrik Krumpolec, Ladislav Valkovic, et al. 2016. “Effects of Carnosine Supplementation on Glucose Metabolism : Pilot Clinical Trial.” Obesity 24 (5): 1027–1034.
Chicago author-date (all authors)
de Courten, Barbora, Michaela Jakubova, Maximilian PJ de Courten, Ivica Just Kukurova, Silvia Vallova, Patrik Krumpolec, Ladislav Valkovic, Timea Kurdiova, Davide Garzon, Silvia Barbaresi, Helena J Teede, Wim Derave, Martin Krssak, Giancarlo Aldini, Jozef Ukropec, and Barbara Ukropcova. 2016. “Effects of Carnosine Supplementation on Glucose Metabolism : Pilot Clinical Trial.” Obesity 24 (5): 1027–1034.
Vancouver
1.
de Courten B, Jakubova M, de Courten MP, Kukurova IJ, Vallova S, Krumpolec P, et al. Effects of carnosine supplementation on glucose metabolism : pilot clinical trial. OBESITY. 2016;24(5):1027–34.
IEEE
[1]
B. de Courten et al., “Effects of carnosine supplementation on glucose metabolism : pilot clinical trial,” OBESITY, vol. 24, no. 5, pp. 1027–1034, 2016.
@article{7276373,
  abstract     = {OBJECTIVE: Carnosine is a naturally present dipeptide in humans and an over-the counter food additive. Evidence from animal studies supports the role for carnosine in the prevention and treatment of diabetes and cardiovascular disease, yet there is limited human data. This study investigated whether carnosine supplementation in individuals with overweight or obesity improves diabetes and cardiovascular risk factors.
METHODS: In a double-blind randomized pilot trial in nondiabetic individuals with overweight and obesity (age 43 ± 8 years; body mass index 31 ± 4 kg/m(2) ), 15 individuals were randomly assigned to 2 g carnosine daily and 15 individuals to placebo for 12 weeks. Insulin sensitivity and secretion, glucose tolerance (oral glucose tolerance test), blood pressure, plasma lipid profile, skeletal muscle ((1) H-MRS), and urinary carnosine levels were measured.
RESULTS: Carnosine concentrations increased in urine after supplementation (P < 0.05). An increase in fasting insulin and insulin resistance was hampered in individuals receiving carnosine compared to placebo, and this remained significant after adjustment for age, sex, and change in body weight (P = 0.02, P = 0.04, respectively). Two-hour glucose and insulin were both lower after carnosine supplementation compared to placebo in individuals with impaired glucose tolerance (P < 0.05).
CONCLUSIONS: These pilot intervention data suggest that carnosine supplementation may be an effective strategy for prevention of type 2 diabetes.},
  author       = {de Courten, Barbora and Jakubova, Michaela and de Courten, Maximilian PJ and Kukurova, Ivica Just and Vallova, Silvia and Krumpolec, Patrik and Valkovic, Ladislav and Kurdiova, Timea and Garzon, Davide and Barbaresi, Silvia and Teede, Helena J and Derave, Wim and Krssak, Martin and Aldini, Giancarlo and Ukropec, Jozef and Ukropcova, Barbara},
  issn         = {1930-7381},
  journal      = {OBESITY},
  keywords     = {INSULIN-RESISTANCE,LIFETIME RISK,DOUBLE-BLIND,DETOXIFICATION,HISTIDINE,DISEASE,TYPE-2,RATS,INDIVIDUALS,GLYCATION},
  language     = {eng},
  number       = {5},
  pages        = {1027--1034},
  title        = {Effects of carnosine supplementation on glucose metabolism : pilot clinical trial},
  url          = {http://dx.doi.org/10.1002/oby.21434},
  volume       = {24},
  year         = {2016},
}

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