Advanced search
1 file | 357.24 KB

Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice

Lisa Thyrion (UGent) , Jeanelle Portelli (UGent) , Robrecht Raedt (UGent) , Griet Glorieux (UGent) , Lars Larsen (UGent) , Mathieu Sprengers (UGent) , Wouter Van Lysebettens (UGent) , Evelien Carrette (UGent) , Jean Delbeke (UGent) , Kristl Vonck (UGent) , et al.
(2016) EPILEPSIA. 57(7). p.e146-e150
Author
Organization
Abstract
There is a continuous drive to find new, improved therapies that have a different mechanism of action in order to help diminish the sizable percentage of persons with pharmacoresistant epilepsy. Uric acid is increasingly recognized as contributing to the pathophysiology of multiple disorders, and there are indications that uric acid might play a role in epileptic mechanisms. Nevertheless, studies that directly investigate its involvement are lacking. In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown. We found that although disruption of urate oxidase resulted in a decreased susceptibility to all behavioral end points in both seizure models, overexpression did not result in any alterations when compared to their wild-type littermates. Our results suggest that a chronic increase in uric acid levels may result in decreased brain excitability.
Keywords
Mice, Urate oxidase, Uric acid, Pentylenetetrazole, Pilocarpine, URIC-ACID, ASCORBIC-ACID, MODELS, RATS

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 357.24 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Thyrion, Lisa, Jeanelle Portelli, Robrecht Raedt, Griet Glorieux, Lars Larsen, Mathieu Sprengers, Wouter Van Lysebettens, et al. 2016. “Disruption, but Not Overexpression of Urate Oxidase Alters Susceptibility to Pentylenetetrazole- and Pilocarpine-induced Seizures in Mice.” Epilepsia 57 (7): e146–e150.
APA
Thyrion, L., Portelli, J., Raedt, R., Glorieux, G., Larsen, L., Sprengers, M., Van Lysebettens, W., et al. (2016). Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. EPILEPSIA, 57(7), e146–e150.
Vancouver
1.
Thyrion L, Portelli J, Raedt R, Glorieux G, Larsen L, Sprengers M, et al. Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. EPILEPSIA. 2016;57(7):e146–e150.
MLA
Thyrion, Lisa, Jeanelle Portelli, Robrecht Raedt, et al. “Disruption, but Not Overexpression of Urate Oxidase Alters Susceptibility to Pentylenetetrazole- and Pilocarpine-induced Seizures in Mice.” EPILEPSIA 57.7 (2016): e146–e150. Print.
@article{7261986,
  abstract     = {There is a continuous drive to find new, improved therapies that have a different mechanism of action in order to help diminish the sizable percentage of persons with pharmacoresistant epilepsy. Uric acid is increasingly recognized as contributing to the pathophysiology of multiple disorders, and there are indications that uric acid might play a role in epileptic mechanisms. Nevertheless, studies that directly investigate its involvement are lacking. In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown. We found that although disruption of urate oxidase resulted in a decreased susceptibility to all behavioral end points in both seizure models, overexpression did not result in any alterations when compared to their wild-type littermates. Our results suggest that a chronic increase in uric acid levels may result in decreased brain excitability.},
  author       = {Thyrion, Lisa and Portelli, Jeanelle and Raedt, Robrecht and Glorieux, Griet and Larsen, Lars and Sprengers, Mathieu and Van Lysebettens, Wouter and Carrette, Evelien and Delbeke, Jean and Vonck, Kristl and Boon, Paul},
  issn         = {0013-9580},
  journal      = {EPILEPSIA},
  language     = {eng},
  number       = {7},
  pages        = {e146--e150},
  title        = {Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice},
  url          = {http://dx.doi.org/10.1111/epi.13410},
  volume       = {57},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: