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Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia

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Abstract
Magnetic nanoparticles (MNPs) can interact with alternating magnetic fields (AMFs) to deposit localized energy for hyperthermia treatment of cancer. Hyperthermia is useful in the context of multimodality treatments with radiation or chemotherapy to enhance disease control without increased toxicity. The unique attributes of heat deposition and transfer with MNPs have generated considerable attention and have been the focus of extensive investigations to elucidate mechanisms and optimize performance. Three-dimensional (3D) simulations are often conducted with the finite element method (FEM) using the Pennes' bioheat equation. In the current study, the Pennes' equation was modified to include a thermal damage-dependent perfusion profile to improve model predictions with respect to known physiological responses to tissue heating. A normal distribution of MNPs in a model liver tumor was combined with empirical nanoparticle heating data to calculate tumor temperature distributions and resulting survival fraction of cancer cells. In addition, calculated spatiotemporal temperature changes were compared among magnetic field amplitude modulations of a base 150-kHz sinusoidal waveform, specifically, no modulation, sinusoidal, rectangular, and triangular modulation. Complex relationships were observed between nanoparticle heating and cancer tissue damage when amplitude modulation and damage-related perfusion profiles were varied. These results are tantalizing and motivate further exploration of amplitude modulation as a means to enhance efficiency of and overcome technical challenges associated with magnetic nanoparticle hyperthermia (MNH).
Keywords
THERMAL DOSIMETRY, CANCER-THERAPY, BASIC PRINCIPLES, MODELS, FIELD, RELAXATION, ABLATION, DAMAGE, MOUSE, FLUID, bioheat transfer, biomagnetism, finite elements, simulation, thermal damage, thermal medicine

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Chicago
Soetaert, Frederik, Luc Dupré, Robert Ivkov, and Guillaume Crevecoeur. 2015. “Computational Evaluation of Amplitude Modulation for Enhanced Magnetic Nanoparticle Hyperthermia.” Biomedical Engineering-biomedizinische Technik 60 (5): 491–504.
APA
Soetaert, F., Dupré, L., Ivkov, R., & Crevecoeur, G. (2015). Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia. BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK, 60(5), 491–504.
Vancouver
1.
Soetaert F, Dupré L, Ivkov R, Crevecoeur G. Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia. BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK. 2015;60(5):491–504.
MLA
Soetaert, Frederik et al. “Computational Evaluation of Amplitude Modulation for Enhanced Magnetic Nanoparticle Hyperthermia.” BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK 60.5 (2015): 491–504. Print.
@article{7261164,
  abstract     = {Magnetic nanoparticles (MNPs) can interact with alternating magnetic fields (AMFs) to deposit localized energy for hyperthermia treatment of cancer. Hyperthermia is useful in the context of multimodality treatments with radiation or chemotherapy to enhance disease control without increased toxicity. The unique attributes of heat deposition and transfer with MNPs have generated considerable attention and have been the focus of extensive investigations to elucidate mechanisms and optimize performance. Three-dimensional (3D) simulations are often conducted with the finite element method (FEM) using the Pennes' bioheat equation. In the current study, the Pennes' equation was modified to include a thermal damage-dependent perfusion profile to improve model predictions with respect to known physiological responses to tissue heating. A normal distribution of MNPs in a model liver tumor was combined with empirical nanoparticle heating data to calculate tumor temperature distributions and resulting survival fraction of cancer cells. In addition, calculated spatiotemporal temperature changes were compared among magnetic field amplitude modulations of a base 150-kHz sinusoidal waveform, specifically, no modulation, sinusoidal, rectangular, and triangular modulation. Complex relationships were observed between nanoparticle heating and cancer tissue damage when amplitude modulation and damage-related perfusion profiles were varied. These results are tantalizing and motivate further exploration of amplitude modulation as a means to enhance efficiency of and overcome technical challenges associated with magnetic nanoparticle hyperthermia (MNH).},
  author       = {Soetaert, Frederik and Dupré, Luc and Ivkov, Robert and Crevecoeur, Guillaume},
  issn         = {0013-5585},
  journal      = {BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK},
  keywords     = {THERMAL DOSIMETRY,CANCER-THERAPY,BASIC PRINCIPLES,MODELS,FIELD,RELAXATION,ABLATION,DAMAGE,MOUSE,FLUID,bioheat transfer,biomagnetism,finite elements,simulation,thermal damage,thermal medicine},
  language     = {eng},
  number       = {5},
  pages        = {491--504},
  title        = {Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia},
  url          = {http://dx.doi.org/10.1515/bmt-2015-0046},
  volume       = {60},
  year         = {2015},
}

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