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Characterization data on the topical carrier DDC642

Eline Desmet (UGent) , STEFANIE BRACKE (UGent) , Katrien Forier (UGent) , Lien Taevernier (UGent) , Marc CA Stuart, Bart De Spiegeleer (UGent) , Koen Raemdonck (UGent) , Mireille Van Gele (UGent) and Jo Lambert (UGent)
(2016) DATA IN BRIEF. 7. p.1204-1210
Author
Organization
Project
Center for nano- and biophotonics (NB-Photonics)
Abstract
This article contains original data, figures and methods used in the characterization of the liposomal carrier ‘DDC642’ for topical applications, described in “An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis” (Desmet et al., 2016). Several elastic liposomal formulations have been evaluated for their ability to encapsulate and deliver RNA interference (RNAi) molecules to cultured primary skin cells. The efficiency and effectiveness of these liposomes were compared to that of our previously characterized liposomes, the ‘SECosomes’ (SEC) (Geusens et al., 2010). After selection of a potential superior carrier, based on encapsulation and transfection efficiency data (Desmet et al., 2016), the selected DDC642 liposomes were characterized more in-depth. Herein, a detailed characterization of the DDC642 liposome and RNAi-loaded lipoplexes is given, including the matching protocols.
Keywords
Lipid-based nanoparticle, Topical drug delivery, Gene therapy, Liposome, RNA interference

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Chicago
Desmet, Eline, STEFANIE BRACKE, Katrien Forier, Lien Taevernier, Marc CA Stuart, Bart De Spiegeleer, Koen Raemdonck, Mireille Van Gele, and Jo Lambert. 2016. “Characterization Data on the Topical Carrier DDC642.” Data in Brief 7: 1204–1210.
APA
Desmet, Eline, BRACKE, S., Forier, K., Taevernier, L., Stuart, M. C., De Spiegeleer, B., Raemdonck, K., et al. (2016). Characterization data on the topical carrier DDC642. DATA IN BRIEF, 7, 1204–1210.
Vancouver
1.
Desmet E, BRACKE S, Forier K, Taevernier L, Stuart MC, De Spiegeleer B, et al. Characterization data on the topical carrier DDC642. DATA IN BRIEF. 2016;7:1204–10.
MLA
Desmet, Eline, STEFANIE BRACKE, Katrien Forier, et al. “Characterization Data on the Topical Carrier DDC642.” DATA IN BRIEF 7 (2016): 1204–1210. Print.
@article{7257880,
  abstract     = {This article contains original data, figures and methods used in the characterization of the liposomal carrier {\textquoteleft}DDC642{\textquoteright} for topical applications, described in {\textquotedblleft}An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis{\textquotedblright} (Desmet et al., 2016). Several elastic liposomal formulations have been evaluated for their ability to encapsulate and deliver RNA interference (RNAi) molecules to cultured primary skin cells. The efficiency and effectiveness of these liposomes were compared to that of our previously characterized liposomes, the {\textquoteleft}SECosomes{\textquoteright} (SEC) (Geusens et al., 2010). After selection of a potential superior carrier, based on encapsulation and transfection efficiency data (Desmet et al., 2016), the selected DDC642 liposomes were characterized more in-depth. Herein, a detailed characterization of the DDC642 liposome and RNAi-loaded lipoplexes is given, including the matching protocols.},
  author       = {Desmet, Eline and BRACKE, STEFANIE and Forier, Katrien and Taevernier, Lien and Stuart, Marc CA and De Spiegeleer, Bart and Raemdonck, Koen and Van Gele, Mireille and Lambert, Jo},
  issn         = {2352-3409},
  journal      = {DATA IN BRIEF},
  keyword      = {Lipid-based nanoparticle,Topical drug delivery,Gene therapy,Liposome,RNA interference},
  language     = {eng},
  pages        = {1204--1210},
  title        = {Characterization data on the topical carrier DDC642},
  url          = {http://dx.doi.org/10.1016/j.dib.2016.03.091},
  volume       = {7},
  year         = {2016},
}

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