Advanced search
1 file | 517.05 KB

Accessory cells for β-cell transplantation

(2016) DIABETES OBESITY & METABOLISM. 18(2). p.115-124
Author
Organization
Abstract
Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycaemic alterations and life-threatening complications. Restoration of the endogenous beta-cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive beta-cell regeneration remain enigmatic and beta-cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in beta-cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes.
Keywords
accessory cells, diabetes, pancreas, transplantation, beta cell, MESENCHYMAL STEM-CELLS, REGULATORY T-CELLS, ENDOTHELIAL PROGENITOR CELLS, TOLEROGENIC DENDRITIC CELLS, HEPATIC STELLATE CELLS, MEDIATED INFLAMMATORY REACTION, TYPE-1 DIABETIC-PATIENTS, HUMAN PANCREATIC-ISLETS, MARROW STROMAL CELLS, TERM GRAFT-SURVIVAL

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 517.05 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Staels, Willem, S De Groef, Y Heremans, V Coppens, N Van Gassen, G Leuckx, M Van de Casteele, et al. 2016. “Accessory Cells for Β-cell Transplantation.” Diabetes Obesity & Metabolism 18 (2): 115–124.
APA
Staels, W., De Groef, S., Heremans, Y., Coppens, V., Van Gassen, N., Leuckx, G., Van de Casteele, M., et al. (2016). Accessory cells for β-cell transplantation. DIABETES OBESITY & METABOLISM, 18(2), 115–124.
Vancouver
1.
Staels W, De Groef S, Heremans Y, Coppens V, Van Gassen N, Leuckx G, et al. Accessory cells for β-cell transplantation. DIABETES OBESITY & METABOLISM. 2016;18(2):115–24.
MLA
Staels, Willem et al. “Accessory Cells for Β-cell Transplantation.” DIABETES OBESITY & METABOLISM 18.2 (2016): 115–124. Print.
@article{7256943,
  abstract     = {Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycaemic alterations and life-threatening complications. Restoration of the endogenous beta-cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive beta-cell regeneration remain enigmatic and beta-cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in beta-cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes.},
  author       = {Staels, Willem and De Groef, S and Heremans, Y and Coppens, V and Van Gassen, N and Leuckx, G and Van de Casteele, M and Van Riet, I and Luttun, A and Heimberg, H and De Leu, N},
  issn         = {1462-8902},
  journal      = {DIABETES OBESITY & METABOLISM},
  keywords     = {accessory cells,diabetes,pancreas,transplantation,beta cell,MESENCHYMAL STEM-CELLS,REGULATORY T-CELLS,ENDOTHELIAL PROGENITOR CELLS,TOLEROGENIC DENDRITIC CELLS,HEPATIC STELLATE CELLS,MEDIATED INFLAMMATORY REACTION,TYPE-1 DIABETIC-PATIENTS,HUMAN PANCREATIC-ISLETS,MARROW STROMAL CELLS,TERM GRAFT-SURVIVAL},
  language     = {eng},
  number       = {2},
  pages        = {115--124},
  title        = {Accessory cells for β-cell transplantation},
  url          = {http://dx.doi.org/10.1111/dom.12556},
  volume       = {18},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: