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Intestinal arsenic absorption is increased by colon suspension from IBD patients

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Abstract
Arsenic (As) is a metalloid that brings about substantial health risks. Since human As exposure mainly occurs through the intake of contaminated water and food, gut epithelial barrier function is a key determinant of As toxicokinetics. If gut barrier function is compromised, as is the case for patients with inflammatory bowel disease (IBD), As may be increasingly ab-sorbed. Using a combination of semi-continuous gut simulators and Caco-2 cell cultures, we describe how simulated colon suspension derived from IBD patients displays a higher apparent permeability coefficient for As (4.2 ±1.3 x 10-5 cm/s) than colon suspension from healthy individuals (0.7 ± 0.1 ∙ 10-5 cm/s). Using a mixture of microorganisms (butyrate producing Clostridia cluster IV and XIVa), the epithelial barrier function was strengthen and thereby lower the epithelial As absorption rates (20±7 %), also in the presence of simulated colon fluids derived from IBD patients. Thus, individuals with compromised gut barrier functioning may be more vulnerable to pollutant exposure in general and inorganic As more specifically. Yet, our in vitro data show that probiotic strategies may alleviate these symptoms.

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MLA
Calatayud Arroyo, Marta, Annelies Geirnaert, Charlotte Grootaert, et al. “Intestinal Arsenic Absorption Is Increased by Colon Suspension from IBD Patients.” Arsenic Research and Global Sustainability : Proceedings of the Sixth International Congress on Arsenic in the Environment. Ed. Prosun Bhattacharya et al. Boca Raton, FL, USA: CRC Press, 2016. 336–338. Print.
APA
Calatayud Arroyo, M., Geirnaert, A., Grootaert, C., Du Laing, G., & Van de Wiele, T. (2016). Intestinal arsenic absorption is increased by colon suspension from IBD patients. In P. Bhattacharya, M. Vahter, J. Jarsjö, J. Kumpiene, A. Ahmad, C. Sparrenbom, G. Jacks, et al. (Eds.), Arsenic research and global sustainability : proceedings of the sixth international congress on arsenic in the environment (pp. 336–338). Presented at the 6th International congress on Arsenic in the Environment (As-2016): Arsenic research and global sustainability, Boca Raton, FL, USA: CRC Press.
Chicago author-date
Calatayud Arroyo, Marta, Annelies Geirnaert, Charlotte Grootaert, Gijs Du Laing, and Tom Van de Wiele. 2016. “Intestinal Arsenic Absorption Is Increased by Colon Suspension from IBD Patients.” In Arsenic Research and Global Sustainability : Proceedings of the Sixth International Congress on Arsenic in the Environment, ed. Prosun Bhattacharya, Marie Vahter, Jerker Jarsjö, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Gunnar Jacks, Marinus Eric Donselaar, Jochen Bundschuh, and Ravi Naidu, 336–338. Boca Raton, FL, USA: CRC Press.
Chicago author-date (all authors)
Calatayud Arroyo, Marta, Annelies Geirnaert, Charlotte Grootaert, Gijs Du Laing, and Tom Van de Wiele. 2016. “Intestinal Arsenic Absorption Is Increased by Colon Suspension from IBD Patients.” In Arsenic Research and Global Sustainability : Proceedings of the Sixth International Congress on Arsenic in the Environment, ed. Prosun Bhattacharya, Marie Vahter, Jerker Jarsjö, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Gunnar Jacks, Marinus Eric Donselaar, Jochen Bundschuh, and Ravi Naidu, 336–338. Boca Raton, FL, USA: CRC Press.
Vancouver
1.
Calatayud Arroyo M, Geirnaert A, Grootaert C, Du Laing G, Van de Wiele T. Intestinal arsenic absorption is increased by colon suspension from IBD patients. In: Bhattacharya P, Vahter M, Jarsjö J, Kumpiene J, Ahmad A, Sparrenbom C, et al., editors. Arsenic research and global sustainability : proceedings of the sixth international congress on arsenic in the environment. Boca Raton, FL, USA: CRC Press; 2016. p. 336–8.
IEEE
[1]
M. Calatayud Arroyo, A. Geirnaert, C. Grootaert, G. Du Laing, and T. Van de Wiele, “Intestinal arsenic absorption is increased by colon suspension from IBD patients,” in Arsenic research and global sustainability : proceedings of the sixth international congress on arsenic in the environment, Stockholm, Sweden, 2016, pp. 336–338.
@inproceedings{7253061,
  abstract     = {Arsenic (As) is a metalloid that brings about substantial health risks. Since human As exposure mainly occurs through the intake of contaminated water and food, gut epithelial barrier function is a key determinant of As toxicokinetics. If gut barrier function is compromised, as is the case for patients with inflammatory bowel disease (IBD), As may be increasingly ab-sorbed. Using a combination of semi-continuous gut simulators and Caco-2 cell cultures, we describe how simulated colon suspension derived from IBD patients displays a higher apparent permeability coefficient for As (4.2 ±1.3 x 10-5 cm/s) than colon suspension from healthy individuals (0.7 ± 0.1 ∙ 10-5 cm/s). Using a mixture of microorganisms (butyrate producing Clostridia cluster IV and XIVa), the epithelial barrier function was strengthen and thereby lower the epithelial As absorption rates (20±7 %), also in the presence of simulated colon fluids derived from IBD patients. Thus, individuals with compromised gut barrier functioning may be more vulnerable to pollutant exposure in general and inorganic As more specifically. Yet, our in vitro data show that probiotic strategies may alleviate these symptoms.},
  author       = {Calatayud Arroyo, Marta and Geirnaert, Annelies and Grootaert, Charlotte and Du Laing, Gijs and Van de Wiele, Tom},
  booktitle    = {Arsenic research and global sustainability : proceedings of the sixth international congress on arsenic in the environment},
  editor       = {Bhattacharya, Prosun and Vahter, Marie and Jarsjö, Jerker and Kumpiene, Jurate and Ahmad, Arslan and Sparrenbom, Charlotte and Jacks, Gunnar and Donselaar, Marinus Eric and Bundschuh, Jochen and Naidu, Ravi},
  isbn         = {9781138029415},
  language     = {eng},
  location     = {Stockholm, Sweden},
  pages        = {336--338},
  publisher    = {CRC Press},
  title        = {Intestinal arsenic absorption is increased by colon suspension from IBD patients},
  year         = {2016},
}