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Function of extracellular vesicle-associated miRNAs in metastasis

Bert Dhondt (UGent) , Quentin Rousseau (UGent) , Olivier De Wever (UGent) and An Hendrix (UGent)
(2016) CELL AND TISSUE RESEARCH. 365(3). p.621-641
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Abstract
Extracellular RNA (exRNA) is functionally transferrable from donor to recipient cells and is protected from RNAses by electrostatic interactions with proteins or by membrane encapsulation. In addition to bioactive RNA, extracellular vesicles (EVs) contain intraluminal and membrane-associated proteins. The cellular context and fitness affect the composition of EVs and thus the outcome of the communication between the EV-producer and recipient cells. Adaptive communication through EVs is particularly important between cancer cells and their local and distant environment and drives life-threatening metastatic progression. Small noncoding RNAs (miRNAs) have been reported in EV isolations and play a role in local invasion, angiogenesis, immune modulation, metastatic niche preparation, colonization and dormancy. The metastasis-related functions attributed to EV-associated miRNAs are currently increasing exponentially in the scientific literature. We must be aware that the correct and efficient separation of non-vesicular entities (soluble proteins, RNA-protein complexes and RNA-lipoprotein complexes) from EVs is necessary to determine the true contribution of EVs in any experiment that describes the molecular content or the functional consequences of the isolated material.
Keywords
Extracellular vesicles, Cell-to-cell communication, miRNA, Pre-metastatic niche, Exosomes, BREAST-CANCER CELLS, MESENCHYMAL STEM-CELLS, PANCREATIC-CANCER, COLORECTAL-CANCER, PREMETASTATIC NICHE, TUMOR PROGRESSION, MULTIPLE-MYELOMA, DOWN-REGULATION, PROMOTE METASTASIS, ENDOTHELIAL-CELLS

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Citation

Please use this url to cite or link to this publication:

MLA
Dhondt, Bert et al. “Function of Extracellular Vesicle-associated miRNAs in Metastasis.” CELL AND TISSUE RESEARCH 365.3 (2016): 621–641. Print.
APA
Dhondt, Bert, Rousseau, Q., De Wever, O., & Hendrix, A. (2016). Function of extracellular vesicle-associated miRNAs in metastasis. CELL AND TISSUE RESEARCH, 365(3), 621–641.
Chicago author-date
Dhondt, Bert, Quentin Rousseau, Olivier De Wever, and An Hendrix. 2016. “Function of Extracellular Vesicle-associated miRNAs in Metastasis.” Cell and Tissue Research 365 (3): 621–641.
Chicago author-date (all authors)
Dhondt, Bert, Quentin Rousseau, Olivier De Wever, and An Hendrix. 2016. “Function of Extracellular Vesicle-associated miRNAs in Metastasis.” Cell and Tissue Research 365 (3): 621–641.
Vancouver
1.
Dhondt B, Rousseau Q, De Wever O, Hendrix A. Function of extracellular vesicle-associated miRNAs in metastasis. CELL AND TISSUE RESEARCH. 2016;365(3):621–41.
IEEE
[1]
B. Dhondt, Q. Rousseau, O. De Wever, and A. Hendrix, “Function of extracellular vesicle-associated miRNAs in metastasis,” CELL AND TISSUE RESEARCH, vol. 365, no. 3, pp. 621–641, 2016.
@article{7250365,
  abstract     = {Extracellular RNA (exRNA) is functionally transferrable from donor to recipient cells and is protected from RNAses by electrostatic interactions with proteins or by membrane encapsulation. In addition to bioactive RNA, extracellular vesicles (EVs) contain intraluminal and membrane-associated proteins. The cellular context and fitness affect the composition of EVs and thus the outcome of the communication between the EV-producer and recipient cells. Adaptive communication through EVs is particularly important between cancer cells and their local and distant environment and drives life-threatening metastatic progression. Small noncoding RNAs (miRNAs) have been reported in EV isolations and play a role in local invasion, angiogenesis, immune modulation, metastatic niche preparation, colonization and dormancy. The metastasis-related functions attributed to EV-associated miRNAs are currently increasing exponentially in the scientific literature. We must be aware that the correct and efficient separation of non-vesicular entities (soluble proteins, RNA-protein complexes and RNA-lipoprotein complexes) from EVs is necessary to determine the true contribution of EVs in any experiment that describes the molecular content or the functional consequences of the isolated material.},
  author       = {Dhondt, Bert and Rousseau, Quentin and De Wever, Olivier and Hendrix, An},
  issn         = {0302-766X},
  journal      = {CELL AND TISSUE RESEARCH},
  keywords     = {Extracellular vesicles,Cell-to-cell communication,miRNA,Pre-metastatic niche,Exosomes,BREAST-CANCER CELLS,MESENCHYMAL STEM-CELLS,PANCREATIC-CANCER,COLORECTAL-CANCER,PREMETASTATIC NICHE,TUMOR PROGRESSION,MULTIPLE-MYELOMA,DOWN-REGULATION,PROMOTE METASTASIS,ENDOTHELIAL-CELLS},
  language     = {eng},
  number       = {3},
  pages        = {621--641},
  title        = {Function of extracellular vesicle-associated miRNAs in metastasis},
  url          = {http://dx.doi.org/10.1007/s00441-016-2430-x},
  volume       = {365},
  year         = {2016},
}

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