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Applied arterial mechanics: from theory to clinical practice

SEBASTIAN VERMEERSCH UGent (2009)
abstract
Cardiovascular disease remains to date the number one cause of death in the Western World. The early detection of subjects at increased cardiovascular risk and the first stages of cardiovascular disease thus remain a spearhead in clinical research. Increasingly this research integrates an engineering approach for the development of new diagnostic tools for use in clinical practice. This thesis therefore focuses on large artery mechanics. An abnormal thickening of the arterial wall of these vessels for instance, or an elevated stiffness of their walls could indicate the early onset of vascular disease and an increased total cardiovascular risk. This thesis contains a number of methodological studies investigating the most optimal way of measuring these and other vascular parameters and exploring how these parameters can best be leveraged to gain knowledge of the status of the cardiovascular system. The parameters and approaches presented are then used on clinical data obtained from a large population study, the Asklepios Study, in which clinical and stiffness parameters of over 2,500 subjects aged between 35 and 55 years old were included. From the results of these analyses we could for instance demonstrate that in the age range covered by the Asklepios Study the stiffness of large elastic arteries increases at a faster rate in women than in men. Next to a proper understanding of how to measure and interpret arterial stiffness parameters, efficient use of these parameters in clinical practice requires a set of reference values to which values measured in an individual can be compared. This thesis also presents the results of an European study in which a database was constructed containing the clinical and stiffness parameter data from over 25,000 subjects from 13 different centers. Based on these data reference values for the clinically most relevant stiffness parameter (carotid-femoral pulse wave velocity) are proposed.
Please use this url to cite or link to this publication:
author
promoter
UGent, UGent and Pierre Boutouyrie
organization
alternative title
Toegepaste arteriële mechanica : van theorie tot klinische praktijk
year
type
dissertation
publication status
published
subject
keyword
arterial mechanics, intima-media thickness, arterial stiffness, pulse wave velocity, reference values
pages
LXII, 266 pages
publisher
Ghent University. Faculty of Engineering
place of publication
Ghent, Belgium
ISBN
978-90-8578-291-9
language
English
UGent publication?
yes
classification
D1
copyright statement
I have retained and own the full copyright for this publication
id
724859
handle
http://hdl.handle.net/1854/LU-724859
alternative location
http://lib.ugent.be/fulltxt/RUG01/001/336/633/RUG01-001336633_2010_0001_AC.pdf
date created
2009-08-11 10:42:58
date last changed
2017-01-02 09:56:53
@phdthesis{724859,
  abstract     = {Cardiovascular disease remains to date the number one cause of death in the Western World. The early detection of subjects at increased cardiovascular risk and the first stages of cardiovascular disease thus remain a spearhead in clinical research. Increasingly this research integrates an engineering approach for the development of new diagnostic tools for use in clinical practice.
This thesis therefore focuses on large artery mechanics. An abnormal thickening of the arterial wall of these vessels for instance, or an elevated stiffness of their walls could indicate the early onset of vascular disease and an increased total cardiovascular risk. This thesis contains a number of methodological studies investigating the most optimal way of measuring these and other vascular parameters and exploring how these parameters can best be leveraged to gain knowledge of the status of the cardiovascular system. The parameters and approaches presented are then used on clinical data obtained from a large population study, the Asklepios Study, in which clinical and stiffness parameters of over 2,500 subjects aged between 35 and 55 years old were included. From the results of these analyses we could for instance demonstrate that in the age range covered by the Asklepios Study the stiffness of large elastic arteries increases at a faster rate in women than in men.
Next to a proper understanding of how to measure and interpret arterial stiffness parameters, efficient use of these parameters in clinical practice requires a set of reference values to which values measured in an individual can be compared. This thesis also presents the results of an European study in which a database was constructed containing the clinical and stiffness parameter data from over 25,000 subjects from 13 different centers. Based on these data reference values for the clinically most relevant stiffness parameter (carotid-femoral pulse wave velocity) are proposed.},
  author       = {VERMEERSCH, SEBASTIAN},
  isbn         = {978-90-8578-291-9},
  keyword      = {arterial mechanics,intima-media thickness,arterial stiffness,pulse wave velocity,reference values},
  language     = {eng},
  pages        = {LXII, 266},
  publisher    = {Ghent University. Faculty of Engineering},
  school       = {Ghent University},
  title        = {Applied arterial mechanics: from theory to clinical practice},
  url          = {http://lib.ugent.be/fulltxt/RUG01/001/336/633/RUG01-001336633\_2010\_0001\_AC.pdf},
  year         = {2009},
}

Chicago
VERMEERSCH, SEBASTIAN. 2009. “Applied Arterial Mechanics: From Theory to Clinical Practice”. Ghent, Belgium: Ghent University. Faculty of Engineering.
APA
VERMEERSCH, SEBASTIAN. (2009). Applied arterial mechanics: from theory to clinical practice. Ghent University. Faculty of Engineering, Ghent, Belgium.
Vancouver
1.
VERMEERSCH S. Applied arterial mechanics: from theory to clinical practice. [Ghent, Belgium]: Ghent University. Faculty of Engineering; 2009.
MLA
VERMEERSCH, SEBASTIAN. “Applied Arterial Mechanics: From Theory to Clinical Practice.” 2009 : n. pag. Print.