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The role of macrophages in obesity-driven chronic liver disease

Lindsey Devisscher UGent, Xavier Verhelst UGent, Isabelle Colle UGent, Hans Van Vlierberghe UGent and Anja Geerts UGent (2016) JOURNAL OF LEUKOCYTE BIOLOGY. 99(5). p.693-698
abstract
Overnutrition and a sedentary lifestyle have resulted in the expansion of human obesity and associated metabolic complications. Nonalcoholic fatty liver disease has become the most common chronic liver disease in Western developed countries and can range from simple hepatic steatosis to a combination of steatosis, inflammation, and ballooning degeneration (nonalcoholic steatohepatitis). Obesity and its related liver disease are both risk factors for hepatocellular carcinoma, the incidence of which is expected to increase rapidly. The pathogenesis of nonalcoholic fatty liver disease and its progression to nonalcoholic steatohepatitis and hepatocellular carcinoma involve a deregulated lipid metabolism and a disruption of immune homeostasis and tissue integrity and are associated with a state of chronic inflammation. Macrophages are immune cells essential for maintenance of organ function and homeostasis but can also contribute to tissue damage and maintain a proinflammatory response. Their function depends on their origin, and tissue and can be converted based on local environmental cues. Resident liver macrophages, Kupffer cells, which function as sentinels, provide a first defense and are assisted by infiltrating monocytes in cases of hepatic insult. Until now, the contribution of tissue-residing and infiltrating macrophages to the onset and progression of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and hepatocellular carcinoma has been only partially unraveled. This review summarizes the current knowledge on the contribution of macrophage subsets to obesity-driven fatty liver disease and its complications and sheds light on still unexplored areas.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
monocyte, Kupffer cell, nonalcoholic fatty liver disease, steatohepatitis, NECROSIS-FACTOR-ALPHA, PROMOTES HEPATIC-FIBROSIS, KUPFFER CELLS, INSULIN-RESISTANCE, ADIPOSE-TISSUE, NONALCOHOLIC STEATOHEPATITIS, HEPATOCELLULAR-CARCINOMA, CHEMICAL HEPATOCARCINOGENESIS, STELLATE CELLS, INFLAMMATION
journal title
JOURNAL OF LEUKOCYTE BIOLOGY
J. Leukoc. Biol.
volume
99
issue
5
pages
693 - 698
Web of Science type
Review
Web of Science id
000374780400007
JCR category
HEMATOLOGY
JCR impact factor
4.018 (2016)
JCR rank
19/70 (2016)
JCR quartile
2 (2016)
ISSN
0741-5400
DOI
10.1189/jlb.5RU0116-016R
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7247647
handle
http://hdl.handle.net/1854/LU-7247647
date created
2016-06-09 14:01:14
date last changed
2018-05-16 14:46:29
@article{7247647,
  abstract     = {Overnutrition and a sedentary lifestyle have resulted in the expansion of human obesity and associated metabolic complications. Nonalcoholic fatty liver disease has become the most common chronic liver disease in Western developed countries and can range from simple hepatic steatosis to a combination of steatosis, inflammation, and ballooning degeneration (nonalcoholic steatohepatitis). Obesity and its related liver disease are both risk factors for hepatocellular carcinoma, the incidence of which is expected to increase rapidly. The pathogenesis of nonalcoholic fatty liver disease and its progression to nonalcoholic steatohepatitis and hepatocellular carcinoma involve a deregulated lipid metabolism and a disruption of immune homeostasis and tissue integrity and are associated with a state of chronic inflammation. Macrophages are immune cells essential for maintenance of organ function and homeostasis but can also contribute to tissue damage and maintain a proinflammatory response. Their function depends on their origin, and tissue and can be converted based on local environmental cues. Resident liver macrophages, Kupffer cells, which function as sentinels, provide a first defense and are assisted by infiltrating monocytes in cases of hepatic insult. Until now, the contribution of tissue-residing and infiltrating macrophages to the onset and progression of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and hepatocellular carcinoma has been only partially unraveled. This review summarizes the current knowledge on the contribution of macrophage subsets to obesity-driven fatty liver disease and its complications and sheds light on still unexplored areas.},
  author       = {Devisscher, Lindsey and Verhelst, Xavier and Colle, Isabelle and Van Vlierberghe, Hans and Geerts, Anja},
  issn         = {0741-5400},
  journal      = {JOURNAL OF LEUKOCYTE BIOLOGY},
  keyword      = {monocyte,Kupffer cell,nonalcoholic fatty liver disease,steatohepatitis,NECROSIS-FACTOR-ALPHA,PROMOTES HEPATIC-FIBROSIS,KUPFFER CELLS,INSULIN-RESISTANCE,ADIPOSE-TISSUE,NONALCOHOLIC STEATOHEPATITIS,HEPATOCELLULAR-CARCINOMA,CHEMICAL HEPATOCARCINOGENESIS,STELLATE CELLS,INFLAMMATION},
  language     = {eng},
  number       = {5},
  pages        = {693--698},
  title        = {The role of macrophages in obesity-driven chronic liver disease},
  url          = {http://dx.doi.org/10.1189/jlb.5RU0116-016R},
  volume       = {99},
  year         = {2016},
}

Chicago
Devisscher, Lindsey, Xavier Verhelst, Isabelle Colle, Hans Van Vlierberghe, and Anja Geerts. 2016. “The Role of Macrophages in Obesity-driven Chronic Liver Disease.” Journal of Leukocyte Biology 99 (5): 693–698.
APA
Devisscher, L., Verhelst, X., Colle, I., Van Vlierberghe, H., & Geerts, A. (2016). The role of macrophages in obesity-driven chronic liver disease. JOURNAL OF LEUKOCYTE BIOLOGY, 99(5), 693–698.
Vancouver
1.
Devisscher L, Verhelst X, Colle I, Van Vlierberghe H, Geerts A. The role of macrophages in obesity-driven chronic liver disease. JOURNAL OF LEUKOCYTE BIOLOGY. 2016;99(5):693–8.
MLA
Devisscher, Lindsey, Xavier Verhelst, Isabelle Colle, et al. “The Role of Macrophages in Obesity-driven Chronic Liver Disease.” JOURNAL OF LEUKOCYTE BIOLOGY 99.5 (2016): 693–698. Print.