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SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana

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Biotechnology for a sustainable economy (Bio-Economy)
Abstract
Control of organ size by cell proliferation and growth is a fundamental process, but the mechanisms that determine the final size of organs are largely elusive in plants. We have previously revealed that the ubiquitin receptor DA1 regulates organ size by repressing cell proliferation in Arabidopsis. Here we report that a mutant allele of STERILE APETALA (SAP) suppresses the da1-1 mutant phenotype. We show that SAP is an F-box protein that forms part of a SKP1/Cullin/F-box E3 ubiquitin ligase complex and controls organ size by promoting the proliferation of meristemoid cells. Genetic analyses suggest that SAP may act in the same pathway with PEAPOD1 and PEAPOD2, which are negative regulators of meristemoid proliferation, to control organ size, but does so independently of DA1. Further results reveal that SAP physically associates with PEAPOD1 and PEAPOD2, and targets them for degradation. These findings define a molecular mechanism by which SAP and PEAPOD control organ size.
Keywords
GENE FAMILY, GROWTH, 26S PROTEASOME, AUXIN RECEPTOR, TRANSCRIPTION FACTOR, STOMATAL DEVELOPMENT, REGULATES CELL EXPANSION, LEAF SIZE, COMPLEX, PROLIFERATION

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Citation

Please use this url to cite or link to this publication:

Chicago
Wang, Zhibiao, Na Li, Shan Jiang, Nathalie Gonzalez Sanchez, Xiahe Huang, Yingchun Wang, Dirk Inzé, and Yunhai Li. 2016. “SCFSAP Controls Organ Size by Targeting PPD Proteins for Degradation in Arabidopsis Thaliana.” Nature Communications 7.
APA
Wang, Zhibiao, Li, N., Jiang, S., Gonzalez Sanchez, N., Huang, X., Wang, Y., Inzé, D., et al. (2016). SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana. NATURE COMMUNICATIONS, 7.
Vancouver
1.
Wang Z, Li N, Jiang S, Gonzalez Sanchez N, Huang X, Wang Y, et al. SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana. NATURE COMMUNICATIONS. 2016;7.
MLA
Wang, Zhibiao, Na Li, Shan Jiang, et al. “SCFSAP Controls Organ Size by Targeting PPD Proteins for Degradation in Arabidopsis Thaliana.” NATURE COMMUNICATIONS 7 (2016): n. pag. Print.
@article{7244258,
  abstract     = {Control of organ size by cell proliferation and growth is a fundamental process, but the mechanisms that determine the final size of organs are largely elusive in plants. We have previously revealed that the ubiquitin receptor DA1 regulates organ size by repressing cell proliferation in Arabidopsis. Here we report that a mutant allele of STERILE APETALA (SAP) suppresses the da1-1 mutant phenotype. We show that SAP is an F-box protein that forms part of a SKP1/Cullin/F-box E3 ubiquitin ligase complex and controls organ size by promoting the proliferation of meristemoid cells. Genetic analyses suggest that SAP may act in the same pathway with PEAPOD1 and PEAPOD2, which are negative regulators of meristemoid proliferation, to control organ size, but does so independently of DA1. Further results reveal that SAP physically associates with PEAPOD1 and PEAPOD2, and targets them for degradation. These findings define a molecular mechanism by which SAP and PEAPOD control organ size.},
  articleno    = {11192},
  author       = {Wang, Zhibiao and Li, Na and Jiang, Shan and Gonzalez Sanchez, Nathalie and Huang, Xiahe and Wang, Yingchun and Inz{\'e}, Dirk and Li, Yunhai},
  issn         = {2041-1723},
  journal      = {NATURE COMMUNICATIONS},
  language     = {eng},
  pages        = {11},
  title        = {SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana},
  url          = {http://dx.doi.org/10.1038/ncomms11192},
  volume       = {7},
  year         = {2016},
}

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